[1]张 靖,姜 华,申 刚,等.经眼动脉灌注化疗视网膜母细胞瘤临床疗效多因素分析[J].介入放射学杂志,2015,(12):1062-1066.
 ZHANG Jing,JIANG Hua,SHEN Gang,et al.Percutaneous transcatheter chemotherapy via ophthalmic artery for retinoblastoma: a multivariate analysis of clinical curative effect[J].journal interventional radiology,2015,(12):1062-1066.
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经眼动脉灌注化疗视网膜母细胞瘤临床疗效多因素分析 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年12期
页码:
1062-1066
栏目:
肿瘤介入
出版日期:
2015-12-25

文章信息/Info

Title:
Percutaneous transcatheter chemotherapy via ophthalmic artery for retinoblastoma: a multivariate analysis of clinical curative effect
作者:
张 靖 姜 华 申 刚 刘珍银 蒋贻洲 李海波 罗 芳刘 浪 肖湘生
Author(s):
ZHANG Jing JIANG Hua SHEN Gang LIU Zhen-yin JIANG Yi-zhou LI Hai-bo LUO Fang LIU Lang XIAO Xiang-sheng
Department of Radiology, Affiliated Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
关键词:
【关键词】 视网膜母细胞瘤 选择性经眼动脉灌注化疗术 多因素分析 美法仑 保眼率
文献标志码:
A
摘要:
【摘要】 目的 评估选择性经眼动脉灌注化疗(SOAI)治疗视网膜母细胞瘤(RB)的临床疗效及安全性,探讨影响临床疗效的因素。方法 回顾性分析2011年1月—2013年4月收治的RB患儿73例107只患眼行SOAI治疗的临床资料,并对术中灌注药物的种类、国际眼内RB肿瘤的分级、眼球供血的造影表现、术前的治疗史等因素与临床疗效的关系进行单因素和多因素分析。结果 343次眼动脉插管中,338次成功插至眼动脉,技术成功率为98.5%。患儿SOAI术后随访3~28个月,中位随访时间为13.6个月。术后84只眼瘤体完全消失,局部形成钙化斑块,总体保眼率为78.5%(84/107);23只眼行眼球摘除术,包括肿瘤复发12例、广泛玻璃体种植4例、视网膜下种植3例、玻璃体出血4例。术后不良反应包括一过性的眼周不适及轻度骨髓抑制。经单因素和多因素分析结果显示,影响RB患儿保眼率的独立预后因素分别是国际眼内RB肿瘤的分级(P=0.04)、术中灌注药物的种类(P<0.01)和术前的治疗史(P<0.01)。结论 SOAI是治疗RB的安全有效的治疗方法,国际眼内RB肿瘤的分级、术中是否联合给药和术前治疗史可作为评估SOAI治疗RB的保眼率的重要指标。

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相似文献/References:

[1]张 靖,姜 华,申 刚,等. 经导管眼动脉灌注化疗治疗晚期视网膜母细胞瘤30例[J].介入放射学杂志,2014,(01):31.
 ZHANG Jing,JIANG Hua,SHEN Gang,et al. Selective ophthalmic arterial injection therapy for advanced retinoblastoma: initial experience in 30 cases[J].journal interventional radiology,2014,(12):31.

备注/Memo

备注/Memo:
(收稿日期:2015-07-30)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2015-12-24