[1]陈 亮,丁 健,王永利,等.镁合金支架植入兔腹主动脉后降解时间观察[J].介入放射学杂志,2015,(11):984-987.
　CHEN Liang,DING Jian,WANG Yong- li,et al.Observation of the degradation time of biodegradable magnesium alloy stent implanted in the abdominal aorta of experimental rabbits[J].journal interventional radiology,2015,(11):984-987.
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年11期
页码:
984-987
栏目:
实验研究
出版日期:
2015-11-25

文章信息/Info

Title:
Observation of the degradation time of biodegradable magnesium alloy stent implanted in the abdominal aorta of experimental rabbits
作者:
陈 亮;  丁 健;  王永利;  王征宇;  刘利珍;  陈锦琼;  彭志清;  刘 强
Author(s):
CHEN Liang;  DING Jian;  WANG Yong- li;  WANG Zheng- yu;  LIU Li- zhen;  CHEN Jin- qiong;  PENG Zhi- qing;  LIU Qiang
Department of Radiology， Third Clinical Medical College， Nanfang Medical University， Guangzhou， Guangdong Province 510515， China
关键词:
【关键词】 可降解镁合金支架;  兔腹主动脉;  降解
文献标志码:
A
摘要:
【摘要】 目的 观察新型可降解镁合金支架——MPM植入兔腹主动脉后的降解时间，评估其对血管壁作用特性。方法 取新西兰大白兔12只，分为4组，每组3只。每只实验兔腹主动脉距肾动脉水平下1 cm处植入MPM支架1枚，术后30、60、90、180 d分别对一组实验兔行腹主动脉DSA检查，评估血管情况并分离支架段血管作病理学分析。结果 术后随访期间，12只实验兔均存活良好。病理检查显示30 d时支架形态完整，扩张完全；60 d时少部分支架支杆降解断裂，支撑力较前减弱；90 d时部分支架支杆断裂；180 d时支架几乎完全被吸收，血管内膜稍有增生。取标本肉眼观察，180 d时仅见少量残留支架。根据直线回归分析，计算出支架完全降解天数为182 d。结论 可降解镁合金支架MPM在兔主动脉中失去支撑作用的时间为182 d，可防止晚期血管再狭窄。

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相似文献/References:

[1]陈 亮,丁 健,王永利,等.镁合金支架植入兔腹主动脉后降解时间及血管内膜增生观察 [J].介入放射学杂志,2017,(05):443.
　CHEN Liang,DING Jian,WANG Yongli,et al.The degradation time and the intimal hyperplasia of biodegradable magnesium alloy stent implanted in the abdominal aorta of experimental rabbits[J].journal interventional radiology,2017,(11):443.
[2]彭志清,陈 亮,丁 健,等.镁合金支架植入兔腹主动脉后血管内膜免疫组化及血清镁离子浓度观察[J].介入放射学杂志,2018,27(06):554.
　PENG Zhiqing,CHEN Liang,DING Jian,et al.The observation of immunohistochemistry of vascular intima and the serum magnesium ion concentration in experimental rabbits after implantation of biodegradable magnesium alloy stent in the abdominal aorta[J].journal interventional radiology,2018,27(11):554.

备注/Memo

备注/Memo:
（收稿日期：２０１5-０6-０1）
（本文编辑：边 佶）
更新日期/Last Update: 2015-11-24