[1]潘春仰,邱建平,陆 林,等.冠状动脉介入治疗后支架内再狭窄相关因素[J].介入放射学杂志,2015,(06):467-471.
　PAN Chun-yang,QIU Jian-ping,LU Lin,et al.Investigation of factors related to the occurrence of in-stent restenosis after percutaneous coronary intervention[J].journal interventional radiology,2015,(06):467-471.
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年06期
页码:
467-471
栏目:
心脏介入
出版日期:
2015-06-25

文章信息/Info

Title:
Investigation of factors related to the occurrence of in-stent restenosis after percutaneous coronary intervention
作者:
潘春仰;  邱建平;  陆 林;  张 奇;  张瑞岩;  沈卫峰
Author(s):
PAN Chun-yang;  QIU Jian-ping;  LU Lin;  ZHANG Qi;  ZHANG Rui-yan;  SHEN Wei-feng
Ningxia Medical University， Yinchuan， Ningxia Hui Autonomous Region 750004， China
关键词:
【关键词】 冠心病;  冠状动脉介入治疗;  药物洗脱支架;  再狭窄
文献标志码:
A
摘要:
【摘要】 目的 探讨冠状动脉药物洗脱支架（DES）植入术后支架内再狭窄（ISR）相关因素。方法 选择2010年9月至2014年9月上海交通大学医学院附属瑞金医院治疗的连续258例雷帕霉素DES植入术后至少1年冠状动脉造影复查确诊为ISR患者（ISR组）和同期262例年龄和性别匹配但无ISR患者（对照组），比较两组患者临床特征、生化指标、术后用药、超声心动图左室射血分数（LVEF）及DES植入治疗特征，采用多因素Logistic回归方法分析与ISR相关因素。结果 与对照组相比，ISR组患者既往心肌梗死史、糖尿病和吸烟多见，血清高敏C反应蛋白（hs-CRP）、糖化血红蛋白、低密度脂蛋白胆固醇（LDL- C）和载脂蛋白B水平显著增高，但LVEF减低（P 均＜0.05）。尽管两组冠状动脉病变数和支架植入部位无显著差异，但ISR组支架直径较小、长度较长，分叉病变多见（P＜0.05）。Logistic回归分析显示既往心肌梗死史、糖尿病、吸烟、hs- CRP、LDL- C、支架长度是ISR独立危险因素，而支架直径、LVEF与ISR呈负相关。结论 雷帕霉素DES植入术后ISR发生与多个临床和冠状动脉病变或介入因素相关，有效控制冠心病危险因素、改善左心室功能，对预防ISR具有重要作用，尤其是小血管、长支架和分叉病变患者。

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备注/Memo

备注/Memo:
（收稿日期：２0１5-０3-26）
（本文编辑：边 佶）
更新日期/Last Update: 2015-06-24