[1]任海涛,李任飞,王月东. 原发性肝癌合并门静脉癌栓的治疗进展[J].介入放射学杂志,2013,(11):965-968.
　REN Hai? tao,LI Ren? fei,WANG Yue? dong.. Recent advances in the treatment of hepatocellular carcinoma with portal vein tumor thrombus[J].journal interventional radiology,2013,(11):965-968.
点击复制

 原发性肝癌合并门静脉癌栓的治疗进展 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年11期
页码:
965-968
栏目:
综 述
出版日期:
2013-11-15

文章信息/Info

Title:
 Recent advances in the treatment of hepatocellular carcinoma with portal vein tumor thrombus
作者:
 任海涛;  李任飞;  王月东
Author(s):
 REN Hai?蛳 tao;  LI Ren?蛳 fei;  WANG Yue?蛳 dong.
 Department of Vascular Intervention， the Fourth Affiliated Hospital， Harbin Medical University， Harbin， Heilongjiang Province 150001， China
关键词:
 ; 【关键词】 原发性肝癌;  门静脉癌栓;  治疗
文献标志码:
A
摘要:
 【摘要】 近年来，随着以肝功能损害程度、肿瘤直径大小和其他相关因素为背景的肝癌各种治疗方法出现，治疗效果评价也逐渐转向以循证医学的模式。目前临床对于肝癌合并门静脉癌栓的治疗方法较多，然而单一治疗方法效果较差，中位生存期较低，合理的治疗原则一直尚未建立。本文通过综述肝癌合并门静脉癌栓的最新治疗进展，以便为临床治疗提供有效参考。

参考文献/References:

 ［1］ Lau WY， Lai EC， Yu SC. Management of prtal vein tumor thrombus［M］//Wy L ed. Hepatocellular carcinoma. Singapore： World Sientific Publishing Co， 2008： 1 ?蛳 24.
［2］ Shuqun C， Mengchao W， Han C， et al. Tumor thrombus types influence the prognosis of hepatocellular carcinoma with the tumor thrombi in the portal vein［J］. Hepatogastroenterology， 2007， 54： 499 ?蛳 502.
［3］ Shi J， Lai EC， Li N， et al. A new classification for hepatocellular carcinoma with portal vein tumor thrombus［J］. J Hepatobiliary Pancreat Sci， 2011， 18： 74 ?蛳 80.
［4］ Shi J， Lai EC， Li N， et al. Surgical treatment of hepatocellular carcinoma with portal vein tumor thrombus［J］. Ann Surg Oncol， 2010， 17： 2073 ?蛳 2080.
［5］ Peng ZW， Guo RP， Zhang YJ， et al. Hepatic resection versus transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma with portal vein tumor thrombus［J］. Cancer， 2012， 118： 4725 ?蛳 4736.
［6］ Yoshidome H， Takeuchi D， Kimura F， et al. Treatment strategy for hepatocellular carcinoma with major portal vein or inferior vena cava invasion： a single institution experience［J］. J Am Coll Surg， 2011， 212： 796 ?蛳 803.
［7］ Nagano H， Wada H， Kobayashi S， et al. Long?蛳 term outcome of combined interferon?蛳 α and 5?蛳 fluorouracil treatment for advanced hepatocellular carcinoma with major portal vein thrombosis［J］. Oncology， 2011， 80： 63 ?蛳 69.
［8］ Kasai K， Ushio A， Kasai Y， et al. Therapeutic efficacy of combination therapy with intra?蛳 arterial 5?蛳 fluorouracil and systemic pegylated interferon α?蛳 2b for advanced hepatocellular carcinoma with portal venous invasion［J］. Cancer， 2012， 118： 3302 ?蛳 3310.
［9］ Choti MA， Geschwind JF. Preoperative sequential TACE and PVE to increase resectability in the cirrhotic patient with HCC［J］. Gastrointest Cancer Res， 2008， 2： 47 ?蛳 48.
［10］ Zhang HH， Sun SB， Han CJ， et al. A 3?蛳 year?蛳 follow?蛳 up study on the prognosis of ‘two?蛳 route chemotherapy’ on liver Cancer patients with portal vein tumor thrombus［J］. Zhonghua Liu Xing Bing Xue Za Zhi， 2012， 33： 1181 ?蛳 1183.
［11］ Luo J， Guo RP， Lai EC， et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein tumor thrombosis： a prospective comparative study［J］. Ann Surg Oncol， 2011， 18： 413 ?蛳 420.
［12］ Schwarz RE， Abou?蛳 Alfa GK， Geschwind JF， et al. Nonoperative therapies for combined modality treatment of hepatocellular Cancer： expert consensus statement［J］. HPB （Oxford）， 2010， 12： 313 ?蛳 320.
［13］ Kim JH， Yoon HK， Kim SY， et al. Transcatheter arterial chemoembolization vs. chemoinfusion for unresectable hepato?蛳 cellular carcinoma in patients with major portal vein thrombosis［J］. Aliment Pharmacol Ther， 2009， 29： 1291 ?蛳 1298.
［14］ Niu ZJ， Ma YL， Kang P， et al. Transarterial chemoembolization compared with conservative treatment for advanced hepatocellular carcinoma with portal vein tumor thrombus： using a new classification［J］. Med Oncol， 2012， 29： 2992 ?蛳 2997.
［15］ Zeng ZC， Fan J， Tang ZY， et al. Prognostic factors for patients with hepatocellular carcinoma with macroscopic portal vein or inferior vena cava tumor thrombi receiving external?蛳 beam radiation therapy［J］. Cancer Sci， 2008， 99： 2510 ?蛳 2517.
［16］ Yoon SM， Lim YS， Won HJ， et al. Radiotherapy plus transarterial chemoembolization for hepatocellular carcinoma invading the portal vein： long?蛳 term patient outcomes［J］. Int J Radiat Oncol Biol Phys， 2012， 82： 2004 ?蛳 2011.
［17］ 翁志成， 杨维竹， 江 娜， 等． CT引导下125I放射性粒子植入治疗肝癌门静脉癌栓的疗效评价［J］． 介入放射学杂志， 2010， 19： 535 ?蛳 539．
［18］ 胡鸿涛， 黎海亮， 郭晨阳， 等． 125I粒子植入联合动脉化学栓塞治疗原发性肝癌合并门静脉癌栓［J］． 中华放射学杂志， 2012， 46： 552 ?蛳 556．
［19］ Yamamoto K， Masuzawa M， Kato M， et al. Evaluation of combined therapy with chemoembolization and ethanol injection for advanced hepatocellular carcinoma［J］. Semin Oncol， 1997， 24： S6 ?蛳 50.
［20］ Hirooka M， Koizumi Y， Kisaka Y， et al. Mass reduction by radiofrequency ablation before hepatic arterial infusion chemotherapy improved prognosis for patients with huge hepatocellular carcinoma and portal vein thrombus［J］. Am J Ro?蛳 entgenol， 2010， 194： 221 ?蛳 226.
［21］ Zhang XB， Wang JH， Yan ZP， et al. Hepatocellular carcinoma invading the main portal vein： treatment with transcatheter arterial chemoembolization and portal vein stenting［J］. Cardiovasc Intervent Radiol， 2009， 32： 52 ?蛳 61.
［22］ Zhang XB， Wang JH， Yan ZP， et al. Hepatocellular carcinoma with main portal vein tumor thrombus： treatment with 3?蛳 dimensional conformal radiotherapy after portal vein stenting and transarterial chemoembolization［J］. Cancer， 2009， 115： 1245 ?蛳 1252.
［23］ Wu LL， Luo JJ， Yan ZP， et al. Comparative study of portal vein stent and TACE combined therapy with or without endovascular implantation of iodine?蛳 125 seeds Strand for treating patients with hepatocellular carcinoma and main portal vein tumor thrombus［J］. Zhonghua Gan Zang Bing Za Zhi， 2012， 20： 915 ?蛳 919.
［24］ Llovet JM， Ricci S， Mazzaferro V， et al. Sorafenib in advanced hepatocellular carcinoma［J］. N Engl J Med， 2008， 359： 378 ?蛳 390.
［25］ Irtan S， Chopin?蛳 Laly X， Ronot M， et al. Complete regression of locally advanced hepatocellular carcinoma induced by sorafenib allowing curative resection［J］. Liver Int， 2011， 31： 740 ?蛳 743.
［26］ Peng BG， He Q， Li JP， et al. Adjuvant transcatheter arterial chemoembolization improves efficacy of hepatectomy for patients with hepatocellular carcinoma and portal vein tumor thrombus［J］. Am J Surg， 2009， 198： 313 ?蛳 318.
［27］ Tang QH， Li AJ， Yang GM， et al. Surgical resection versus conformal radiotherapy combined with TACE for resectable hepatocellular carcinoma with portal vein tumor thrombus： a comparative study［J］. World J Surg， 2013， 37： 1362 ?蛳 1370.

相似文献/References:

[1].Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].介入放射学杂志,2007,(10):718.
　ZHANG He,LI Ming-hua,WANG Chun,et al.Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].journal interventional radiology,2007,(11):718.
[2]李统怀,郑红枫. 子宫动脉栓塞治疗子宫瘢痕妊娠１１例[J].介入放射学杂志,2011,(11):898.
　LI Tong-huai,ZHENG Hong-feng..Clinical application of uterine artery embolization in treating uterine scar pregnancy[J].journal interventional radiology,2011,(11):898.
[3]吕维富,张爱武,周春泽,等. 子宫动脉的三维DSA表现及其最佳显示体位探讨[J].介入放射学杂志,2011,(11):853.
　LV Wei-fu,ZHANG Ai-wu,ZHOU Chun-ze,et al.3D-DSA findings of uterine artery and its optimal projection position[J].journal interventional radiology,2011,(11):853.
[4]张 靖,周少毅,陈昆山,等.经导管动脉硬化栓塞联合注射硬化治疗婴儿颌面部巨大高流量血管瘤[J].介入放射学杂志,2011,(11):848.
　ZHANG Jing,ZHOU Shao-yi,CHEN Kun-shan,et al.Transcatheter arterial sclerosing embolization with injection sclerotherapy for the treatment of huge and high-flow maxillofacial hemangiomas in infants[J].journal interventional radiology,2011,(11):848.
[5]谢小西,吕银祥,章宏欣,等. 肝动脉化疗栓塞、射频消融联合１２５Ⅰ粒子植入 治疗原发性肝癌的临床应用[J].介入放射学杂志,2011,(11):863.
　XIE Xiao-xi,LV Yin-xiang,ZHANG Hong-xin,et al.The clinical application of TACE together with RFA and 125Ⅰ seed implantation in treating hepatocellular carcinoma[J].journal interventional radiology,2011,(11):863.
[6]王铭义,王 峰. 脑灌注成像在颈动脉狭窄介入治疗中的应用[J].介入放射学杂志,2011,(11):915.
　WANG Ming-yi,WANG Feng..Application of brain perfusion imaging in interventional treatment of carotid artery stenosis[J].journal interventional radiology,2011,(11):915.
[7]杜 猛,张锦生. 介入治疗急性深静脉血栓的临床观察[J].介入放射学杂志,2011,(11):858.
　DU Meng,ZHANG Jing-sheng..Interventional therapy for acute deep venous thrombosis: a clinical observation[J].journal interventional radiology,2011,(11):858.
[8]孟庆娜,李国庆,白晓冬. 急性心肌梗死介入治疗术中恶心呕吐的护理[J].介入放射学杂志,2011,(11):913.
　MENG Qing-na,LI Guo-qing,BAI Xiao-dong..The nursing care of nausea and vomiting occurred in interventional treatment for acute myocardial infarction[J].journal interventional radiology,2011,(11):913.
[9]王海亭,蒋忠仆,周 毅,等. 透视引导下鱼肝油酸钠泡沫硬化剂治疗下肢静脉曲张３０例[J].介入放射学杂志,2011,(11):905.
　WANG Hai-ting,JIANG Zhong-pu,ZHOU Yi,et al.Fluoroscopically-guided foam sclerotherapy with sodium morrhuate for the treatment of lower extremity varices[J].journal interventional radiology,2011,(11):905.
[10]杜 鲲,管 生,胡小波,等. 原发性肝癌ＴＡＣＥ术后完全缓解病灶磁共振 ＡＤＣ值可重复性及一致性研究[J].介入放射学杂志,2011,(11):867.
　DU Kun,GUAN Sheng,HU Xiao-bo,et al.Magnetic resonance apparent diffusion coefficient values of the completely remitted lesions of primary hepatocellular carcinoma after TACE: a study of their repeatability and consistency[J].journal interventional radiology,2011,(11):867.
[11]程洪涛,郭晨阳,黎海亮,等.ＴＡＣＥ联合射频消融治疗原发性肝癌疗效的影响因素分析[J].介入放射学杂志,2012,(03):216.
　,,et al.ＴＡＣＥ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ＣＴｇｕｉｄｅｄ ｐｅｒｃｕｔａｎｅｏｕｓ ｒａｄｉｏｆｒｅｑｕｅｎｃｙ ａｂｌａｔｉｏｎ ｆｏｒ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｐｒｉｍａｒｙ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ： ａｎ ａｎａｌｙｓｉｓ ｏｆ ｆａｃｔｏｒｓ ａｆｆｅｃｔｉｎｇ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｒｅｓｕｌｔ [J].journal interventional radiology,2012,(11):216.
[12]张晓前,郭 鹏,党之俊,等.金龙胶囊联合介入疗法治疗原发性肝癌临床观察[J].介入放射学杂志,2012,(03):249.
　,,et al.Ｋｉｎｇｌｏｎｇ ｃａｐｓｕｌｅｓ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｉｎｔｅｒｖｅｎｔｉｏｎａｌ ｔｈｅｒａｐｙ ｆｏｒ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ： ｃｌｉｎｉｃａｌ ｏｂｓｅｒｖａｔｉｏｎ [J].journal interventional radiology,2012,(11):249.
[13]姚红响,陈根生,诸葛英,等.肝动脉化疗栓塞联合ＣＴ引导射频消融序贯治疗中小肝癌的临床应用[J].介入放射学杂志,2012,(04):301.
　,,et al.Ｓｅｑｕｅｎｔｉａｌ ｔｒｅａｔｍｅｎｔ ｗｉｔｈ ＴＡＣＥ ａｎｄ ＣＴｇｕｉｄｅｄ ＲＦＡ ｆｏｒ ｓｍａｌｌ ａｎｄ ｍｏｄｅｒａｔｅ ｓｉｚｅｄ ＨＣＣ [J].journal interventional radiology,2012,(11):301.
[14]姚全军,胡鸿涛,黎海亮,等.Ｃ臂ＣＴ成像在乏血供原发性肝癌诊疗中的临床应用[J].介入放射学杂志,2012,(04):305.
　,,et al.Ｔｈｅ ｃｌｉｎｉｃａｌ ａｐｐｌｉｃａｔｉｏｎ ｏｆ Ｃ ａｒｍ ＣＴ ｉｍａｇｉｎｇ ｉｎ ｄｉａｇｎｏｓｉｎｇ ａｎｄ ｔｒｅａｔｉｎｇ ｈｙｐｏｖａｓｃｕｌａｒ ｐｒｉｍａｒｙ ｈｅｐａｔｉｃ ｃａｒｃｉｎｏｍａｓ [J].journal interventional radiology,2012,(11):305.
[15]高 嵩,朱旭,杨仁杰,等. ＴＡＣＥ联合奥沙利铂、氟尿嘧啶、亚叶酸钙肝动脉化疗治疗中晚期原发性肝癌[J].介入放射学杂志,2012,(05):377.
　,,et al. ＴＡＣＥ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｈｅｐａｔｉｃ ａｒｔｅｒｉａｌ ｉｎｆｕｓｉｏｎ ｃｈｅｍｏｔｈｅｒａｐｙ ｕｓｉｎｇ ｏｘａｌｉｐｌａｔｉｎ， ５ｆｌｕｏｒｏｕｒａｃｉｌ ａｎｄ ｆｏｌｉｎｉｃ ａｃｉｄ ｆｏｒ ｉｎｔｅｒｍｅｄｉａｔｅ ａｎｄ ａｄｖａｎｃｅｄ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ[J].journal interventional radiology,2012,(11):377.
[16]刘 昕,吕维富,鲁 东,等. 动脉介入栓塞治疗肝癌破裂出血[J].介入放射学杂志,2012,(07):586.
　LIU Xin,LV Wei- fu,LU Dong,et al. Interventional treatment of hepatic bleeding due to spontaneous rupture of hepatocellular carcinoma[J].journal interventional radiology,2012,(11):586.
[17]张志良,杨学东,温阿明,等. 经动脉化疗栓塞联合伽玛刀治疗原发性肝癌的疗效评价[J].介入放射学杂志,2012,(07):596.
　ZHANG Zhi- liang,YANG Xue- dong,WEN A-ming,et al. Evaluation of TACE combined with gamma?蛳 knife radiotherapy for primary hepatocellular carcinoma[J].journal interventional radiology,2012,(11):596.
[18]赵许亚,周 石.TACE联合经皮瘤内注射碘油吡柔比星乳剂治疗中晚期肝癌疗效分析[J].介入放射学杂志,2012,(08):675.
　ZHAO Xu- ya,ZHOU Shi.. Transcatheter artery chemoembolization combined with percutaneous intratumoral injection of Lipiodol emulsion of pirarubicin for advanced hepatocellular carcinomas： an analysis of clinical efficacy[J].journal interventional radiology,2012,(11):675.
[19]王少雷,李 森,魏 宏,等.奥沙利铂与吡喃阿霉素介入治疗原发性肝癌的比较研究[J].介入放射学杂志,2012,(09):738.
　WANG Shao- lei,LI Sen,WEI Hong,et al. Interventional chemoembolization therapy of primary hepatocellular carcinoma： a comparative study between oxaliplatin and therarubicin[J].journal interventional radiology,2012,(11):738.
[20]李虎子,郭 志,王海涛,等.肝细胞癌患者TACE后外周血调节性T细胞水平对预后的影响[J].介入放射学杂志,2012,(12):998.
　LI Hu? zi,GUO Zhi,WANG Hai? tao,et al. The effect of regulatory T cells level in peripheral blood on the prognosis in HCC patients after TACE [J].journal interventional radiology,2012,(11):998.

备注/Memo

备注/Memo:
 （收稿日期：２０１3-０6-14）
更新日期/Last Update: