[1]陈火元,朱鲜阳,韩秀敏,等. 成人房间隔缺损合并肺动脉高压患者导管封堵术后左心功能变化[J].介入放射学杂志,2013,(05):365-368.
　CHEN Huo? yuan,ZHU Xian? yang,HAN Xiu? min,et al.Changes of the left ventricular function after transcatheter closure for atrial septal defect associated with pulmonary arterial hypertension in adult patients[J].journal interventional radiology,2013,(05):365-368.
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 成人房间隔缺损合并肺动脉高压患者导管封堵术后左心功能变化 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年05期
页码:
365-368
栏目:
心脏介入
出版日期:
2013-05-22

文章信息/Info

Title:
Changes of the left ventricular function after transcatheter closure for atrial septal defect associated with pulmonary arterial hypertension in adult patients
作者:
 陈火元;  朱鲜阳;  韩秀敏;  侯传举;  张端珍;  王琦光;  盛晓棠;  崔春生
Author(s):
 CHEN Huo?蛳 yuan;  ZHU Xian?蛳 yang;  HAN Xiu?蛳 min;  HOU Chuan?蛳 ju;  ZHANG Duan?蛳 zhen;  WANG Qi?蛳 guang;  SHENG Xiao?蛳 tang;  CUI Chun?蛳 sheng.
 Department of Congenital Heart Disease， General Hospital of Shenyang Military Region， Shenyang 110016， China
关键词:
 ; 【关键词】 房间隔缺损;  肺动脉高压;  介入治疗;  左心功能
文献标志码:
A
摘要:
 
【摘要】 目的 利用超声心动图评价成人房间隔缺损（ASD）合并肺动脉高压（PAH）患者导管封堵术后左心功能的变化。方法 2009年6月至2011年8月收治年龄 ≥ 40岁的ASD患者75例，分为PAH组36例和无PAH组39例，均经胸超声心动图测量ASD大小以及术前、术后1 d、1、3个月的左心功能。心导管测肺动脉压及分流量。结果 所有患者均成功行ASD封堵术，PAH组与无PAH组年龄分别为（51.7 ± 9.3）岁和（49.3 ± 6.0）岁，ASD大小为（20.6 ± 6.8）mm和（20.6 ± 6.8）mm，选用封堵器大小为18 ~ 42（30.8 ± 9.1）mm和9 ~ 40（27.5 ± 7.4）mm。心导管测量PAH组肺动脉收缩压（sPAP）为（57.8 ± 16.0）mmHg，平均肺动脉压（mPAP）为26 ~ 62（37.1 ± 7.7）mmHg，无PAH组sPAP为（28.9 ± 3.9）mmHg，mPAP为10 ~ 23（15.9 ± 2.8）mmHg。其中PAH组有3例选用带孔ASD封堵器封堵。两组比较，PAH组左室舒张末期内径、左室舒张末期容积、左室搏出量、左室射血分数均较无PAH组低（P < 0.05）。PAH组导管封堵后肺动脉压明显下降（P < 0.01），术后随访左室舒张末期内径、左室舒张末期容积、左室搏出量、左室射血分数均增大（P < 0.05）。结论 ASD合并PAH患者左心功能损害较无PAH组更严重，介入治疗后左心功能明显好转，能防止心功能进一步恶化。

参考文献/References:

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（收稿日期：２０１2-12-12） 
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