[1]陆小华,朱小庆,茅国新.肝细胞癌相关单核苷酸多态性的研究进展[J].介入放射学杂志,2013,(06):520-524.
　LU Xiao? hua,ZHU Xiao? qing,MAO Guo? xin.. Hepatocellular carcinoma?蛳 related single nucleotide polymorphisms： recent advances in research[J].journal interventional radiology,2013,(06):520-524.
点击复制

肝细胞癌相关单核苷酸多态性的研究进展 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年06期
页码:
520-524
栏目:
综述
出版日期:
2013-06-24

文章信息/Info

Title:
 Hepatocellular carcinoma?蛳 related single nucleotide polymorphisms： recent advances in research
作者:
陆小华;  朱小庆;  茅国新
Author(s):
 LU Xiao?蛳 hua;  ZHU Xiao?蛳 qing;  MAO Guo?蛳 xin.
 Department of Interventional Radiology， Affiliated Hospital of Nantong University， Nantong 226001， China
关键词:
 ; 【关键词】 肝细胞癌;  单核苷酸多态性;  遗传易感性
文献标志码:
A
摘要:
 【摘要】 肝细胞癌是临床上最常见的恶性肿瘤之一。大量研究表明，遗传因素在肝细胞癌发病中发挥重要作用。单核苷酸多态性作为第3代遗传标记，是人类基因组中最常见的多态性表现形式，已成为研究肝细胞癌遗传易感性的重要手段。对其深入研究将有利于更好的采取预防、诊断和治疗措施。

参考文献/References:

 ［1］ 李 伟， 刘传苗， 赵守松． 原发性肝细胞癌患者肝组织中乙型肝炎病毒X基因的变异［Ｊ］． 实用医学杂志， 2009， 25： 180 ?蛳 182．
［2］ 倪秀莹， 王 涛， 杨 伟， 等． 乙型肝炎病毒A1762T/G1764A突变与原发性肝细胞癌的关系［Ｊ］． 中国现代普通外科进展， 2011， 14： 59 ?蛳 61， 74．
［3］ Yoon YJ， Chang HY， Ahn SH， et al. MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection［Ｊ］. Carcinogenesis， 2008， 29： 1192 ?蛳 1196.
［4］ Sumbul AT， Akkiz H， Bayram S， et al. p53 codon 72 pol?蛳 morphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population： a case?蛳 control study［Ｊ］. Mol Biol Rep， 2012， 39： 1639 ?蛳 1647.
［5］ Ding J， Gao Y， Liu R， et al. Association of PTEN polmorphisms with susceptibility to hepatocellular carcinoma in a Han Chinese population［Ｊ］. DNA Cell Biol， 2011， 30： 229 ?蛳 234.
［6］ 叶新平， 彭 涛， 刘唐威， 等． ALDH2和CYP2E1基因多态性及饮酒习惯与肝细胞癌易感性的关系［Ｊ］． 卫生研究， 2010， 39： 42 ?蛳 45．
［7］ Imaizumi T， Higaki Y， Hara M， et al. Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population［Ｊ］. Carcinogenesis， 2009， 30： 1729 ?蛳 1734.
［8］ 贺菽嘉，顾永耀，林文珍，等． EPHX1基因多态性与原发性HCC易感性的关系［Ｊ］． 肿瘤， 2008， 28： 125 ?蛳 128．
［9］ Kiran M， Saxena R， Chawla YK， et al. Polymorphism of DNA repair gene XRCC1 and hepatitis?蛳 related hepatocellular carci?蛳 noma risk in Indian population［Ｊ］. Mol Cell Biochem， 2009， 327： 7 ?蛳 13.
［10］ Pan HZ， Liang J， Yu Z， et al. Polymorphism of DNA repair gene XRCC1 and hepatocellular carcinoma risk in Chinese population［Ｊ］. Asian Pac J Cancer Prev， 2011， 12： 2947 ?蛳 2950.
［11］ Ji L， Zeng X， Li L， et al. Interaction between the single?蛳nucleotide polymorphism of DNA repair gene hOGG1 and HBV infection and its susceptibility to hepatocellular carcinoma［Ｊ］. Wei Sheng Yan Jiu， 2011， 40： 705 ?蛳 708.
［12］ Yuan T， Wei J， Luo J， et al. Polymorphisms of base?蛳 excision repair genes hOGG1 326cys and XRCC1 280His increase hepatocellular carcinoma risk［Ｊ］. Dig Dis Sci， 2012， 57： 2451 ?蛳 2457.
［13］ Long XD， Ma Y， Zhou YF， et al. XPD codon 312 and 751 polymorphisms， and AFB1 exposure， and hepatocellular carcinoma risk［Ｊ］. BMC Cancer， 2009， 9： 400.
［14］ Falleti E， Fabris C， Toniutto P， et al. Interleukin?蛳6 polymorphisms and gender： relationship with the occurrence of hepatocellular carcinoma in patients with end?蛳 stage liver disease［Ｊ］. Oncology， 2009， 77： 304 ?蛳 313.
［15］ Chien MH， Yeh CB， Li YC， et al. Relationship of interleukin?蛳 8 gene polymorphisms with hepatocellular carcinoma susceptibility and pathological development［Ｊ］. J Surg Oncol， 2011， 104： 798 ?蛳 803.
［16］ Tseng LH， Lin MT， Shau WY， et al. Correlation of interleukin?蛳10 gene haplotype with hepatocellular carcinoma in Taiwan［Ｊ］. Tissue Antigens， 2006， 67： 127 ?蛳 133.
［17］ Qiu XQ， Bei CH， Yu HP， et al. Study on the relationship between single?蛳 nucleotide polymorphisms in IL?蛳 6， IL?蛳 10 genes and HBV?蛳 related hepatocellular carcinoma［Ｊ］. Zhonghua Liu Xing Bing Xue Za Zhi， 2011， 32： 510 ?蛳 513.
［18］ 刘 莉， 刘 政， 徐 研， 等． IL?蛳 12基因多态性与原发性肝细胞HCC遗传易感性的关联研究［Ｊ］． 南京医科大学学报， 2010， 30： 34 ?蛳 38．
［19］ Park JS， Cheong JY， Kang JK， et al. Association of interleukin?蛳12 gene polymorphism with persistence of hepatitis B virus infection and hepatocellular carcinoma［Ｊ］. Korean J Gastroe?蛳 nterol， 2007， 50： 313 ?蛳 318.
［20］ Zhong JH， You XM， Gong WF， et al. Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma： a meta?蛳 analysis［Ｊ］. PLoS One， 2012， 7： e32159.
［21］ Li Y， Xie Q， Lu F， et al. Association between epidermal growth factor 61A/G polymorphism and hepatocellular carcinoma susceptibility in Chinese patients［Ｊ］. Liver Int， 2010， 30： 112 ?蛳 118.
［22］ Giacalone A， Montalto G， Giannitrapani L， et al. Association between single nucleotide polymorphisms in the cyclooxygenase?蛳2， tumor necrosis factor?蛳 α， and vascular endothelial growth factor?蛳 A genes， and susceptibility to hepatocellular carcinoma［Ｊ］. OMICS， 2011， 15： 193 ?蛳 196.
［23］ Wu LM， Xie HY， Zhou L， et al. A single nucleotide polymorphism in the vascular endothelial growth factor gene is associated with recurrence of hepatocellular carcinoma after transplantation［Ｊ］. Arch Med Res， 2009， 40： 565 ?蛳 570.
［24］ Qi P， Chen YM， Wang H， et al. -509C > T polymorphism in the TGF?蛳 beta1 gene promoter， impact on the hepatocellular carcinoma risk in Chinese patients with chronic hepatitis B virus infection［Ｊ］. Cancer Immunol Immunother， 2009， 58： 1433 ?蛳 1440.
［25］ Falleti E， Fabris C， Toniutto P， et al. TGF?蛳 beta1 genotypes in cirrhosis： relationship with the occurrence of liver cancer［Ｊ］. Cytokine， 2008， 44： 256 ?蛳 261.
［26］ Basturk B， Karasu Z， Kilic M， et al. Association of TNF?蛳 alpha ?蛳 308 polymorphism with the outcome of hepatitis B virus infection in Turkey［Ｊ］. Infect Genet Evol， 2008， 8： 20 ?蛳 25.
［27］ 宋韶芳， 郜艳晖， 陈思东． TNF?蛳 α?蛳 308位点基因多态性与环境因素在HCC发生中的交互作用［Ｊ］． 广东药学院学报， 2009， 25： 196 ?蛳 201．
［28］ 许东奎， 张雪梅， 赵 平， 等． COX?蛳 2基因启动子区单核苷酸多态与HCC遗传易感性的关系［Ｊ］． 中华肝胆外科杂志， 2008， 14： 840 ?蛳 843．
［29］ 范雪娇， 仇小强， 余红平， 等． COX?蛳 2基因单核苷酸多态性与肝细胞癌关联的研究［Ｊ］． 中华肿瘤防治杂志， 2011， 18： 405 ?蛳 409．
［30］ Akkiz H， Bayram S， Bekar A， et al. Functional polymorphisms of cyclooxygenase?蛳 2 gene and risk for hepatocellular carcinoma［Ｊ］. Mol Cell Biochem， 2011， 347： 201 ?蛳 208.

相似文献/References:

[1].Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].介入放射学杂志,2007,(10):718.
　ZHANG He,LI Ming-hua,WANG Chun,et al.Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].journal interventional radiology,2007,(06):718.
[2]李统怀,郑红枫. 子宫动脉栓塞治疗子宫瘢痕妊娠１１例[J].介入放射学杂志,2011,(11):898.
　LI Tong-huai,ZHENG Hong-feng..Clinical application of uterine artery embolization in treating uterine scar pregnancy[J].journal interventional radiology,2011,(06):898.
[3]吕维富,张爱武,周春泽,等. 子宫动脉的三维DSA表现及其最佳显示体位探讨[J].介入放射学杂志,2011,(11):853.
　LV Wei-fu,ZHANG Ai-wu,ZHOU Chun-ze,et al.3D-DSA findings of uterine artery and its optimal projection position[J].journal interventional radiology,2011,(06):853.
[4]张 靖,周少毅,陈昆山,等.经导管动脉硬化栓塞联合注射硬化治疗婴儿颌面部巨大高流量血管瘤[J].介入放射学杂志,2011,(11):848.
　ZHANG Jing,ZHOU Shao-yi,CHEN Kun-shan,et al.Transcatheter arterial sclerosing embolization with injection sclerotherapy for the treatment of huge and high-flow maxillofacial hemangiomas in infants[J].journal interventional radiology,2011,(06):848.
[5]谢小西,吕银祥,章宏欣,等. 肝动脉化疗栓塞、射频消融联合１２５Ⅰ粒子植入 治疗原发性肝癌的临床应用[J].介入放射学杂志,2011,(11):863.
　XIE Xiao-xi,LV Yin-xiang,ZHANG Hong-xin,et al.The clinical application of TACE together with RFA and 125Ⅰ seed implantation in treating hepatocellular carcinoma[J].journal interventional radiology,2011,(06):863.
[6]王铭义,王 峰. 脑灌注成像在颈动脉狭窄介入治疗中的应用[J].介入放射学杂志,2011,(11):915.
　WANG Ming-yi,WANG Feng..Application of brain perfusion imaging in interventional treatment of carotid artery stenosis[J].journal interventional radiology,2011,(06):915.
[7]杜 猛,张锦生. 介入治疗急性深静脉血栓的临床观察[J].介入放射学杂志,2011,(11):858.
　DU Meng,ZHANG Jing-sheng..Interventional therapy for acute deep venous thrombosis: a clinical observation[J].journal interventional radiology,2011,(06):858.
[8]孟庆娜,李国庆,白晓冬. 急性心肌梗死介入治疗术中恶心呕吐的护理[J].介入放射学杂志,2011,(11):913.
　MENG Qing-na,LI Guo-qing,BAI Xiao-dong..The nursing care of nausea and vomiting occurred in interventional treatment for acute myocardial infarction[J].journal interventional radiology,2011,(06):913.
[9]王海亭,蒋忠仆,周 毅,等. 透视引导下鱼肝油酸钠泡沫硬化剂治疗下肢静脉曲张３０例[J].介入放射学杂志,2011,(11):905.
　WANG Hai-ting,JIANG Zhong-pu,ZHOU Yi,et al.Fluoroscopically-guided foam sclerotherapy with sodium morrhuate for the treatment of lower extremity varices[J].journal interventional radiology,2011,(06):905.
[10]杜 鲲,管 生,胡小波,等. 原发性肝癌ＴＡＣＥ术后完全缓解病灶磁共振 ＡＤＣ值可重复性及一致性研究[J].介入放射学杂志,2011,(11):867.
　DU Kun,GUAN Sheng,HU Xiao-bo,et al.Magnetic resonance apparent diffusion coefficient values of the completely remitted lesions of primary hepatocellular carcinoma after TACE: a study of their repeatability and consistency[J].journal interventional radiology,2011,(06):867.
[11]李晓峰,钱国军,张 磊,等. 微波高功率条件下消融原发性肝癌的初步研究[J].介入放射学杂志,2011,(12):974.
　LI Xiao-feng,QIAN Guo-jun,ZHANG Lei,et al.Microwave ablation with high output power for the treatment of hepatocellular carcinoma: a preliminary study[J].journal interventional radiology,2011,(06):974.
[12]姚雪松,李 槐.不可手术切除的肝细胞癌的疗效评价标准——改良ＲＥＣＩＳＴ标准更可靠[J].介入放射学杂志,2012,(03):177.
　. Ｔｈｅｒａｐｅｕｔｉｃ ｅｖａｌｕａｔｉｏｎ ｃｒｉｔｅｒｉｏｎ ｏｆ ｉｎｏｐｅｒａｂｌｅ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ： ｍｏｄｉｆｉｅｄ ＲＥＣＩＳＴ ａｓ ａ ｍｏｒｅ ｒｅｌｉａｂｌｅ ｓｔａｎｄａｒｄ[J].journal interventional radiology,2012,(06):177.
[13]孙 磊,施海彬,刘 圣,等.肝细胞癌肝动脉门静脉分流形成的相关因素分析[J].介入放射学杂志,2012,(03):206.
　,,et al.Ｔｈｅ ｆａｃｔｏｒｓ ｒｅｌａｔｅｄ ｔｏ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ａｒｔｅｒｉｏｐｏｒｔａｌ ｓｈｕｎｔｉｎｇ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ [J].journal interventional radiology,2012,(06):206.
[14]梁茂全,苏洪英. 肝癌化疗栓塞前后甲胎蛋白变化模式的临床意义[J].介入放射学杂志,2012,(04):333.
　.Ｔｈｅ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｐａｔｔｅｒｎ ｏｆ ｓｅｒｕｍ аｆｅｔｏｐｒｏｔｅｉｎ ａｆｔｅｒ ｔｒａｎｓｃａｔｈｅｔｅｒ ａｒｔｅｒｉａｌ ｃｈｅｍｏｅｍｂｏｌｉｚａｔｉｏｎ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａ： ｉｔｓ ｃｌｉｎｉｃａｌ ｓｉｇｎｉｆｉｃａｎｃｅ [J].journal interventional radiology,2012,(06):333.
[15]沈海洋,刘瑞宝,刘 岩,等. 肝右叶前、后段原发性肝癌TACE后VEGF及CD34的表达水平 ；[J].介入放射学杂志,2012,(06):469.
　SHEN Hai- yang,LIU Rui- bao,LIU Yan,et al. The expression levels of vascular endothelial growth factor and CD34 in residual cancerous tissues of primary hepatocellular carcinoma located at anterior and posterior segments of right lobe liver after TACE[J].journal interventional radiology,2012,(06):469.
[16]彭辽河,胡晓燕,李 杰,等. 18F-FDG PET/CT显像在肝细胞癌TACE术后残留或复发病灶检出中的应用价值[J].介入放射学杂志,2012,(08):636.
　PENG Liao- he,HU Xiao- yan,LI Jie,et al. Clinical application of 18F- FDG PET/CT imaging in detecting residual lesions or recurrence foci of hepatocellular carcinoma after TACE treatment[J].journal interventional radiology,2012,(06):636.
[17]姚雪松,闫 东,曾辉英,等. TACE联合索拉非尼治疗不能手术切除肝细胞肝癌50例[J].介入放射学杂志,2013,(05):381.
　YAO Xue? song,YAN Dong,ZENG Hui? ying,et al. Ttransarterial chemoembolization combined with sorafenib for inoperable hepatocellular carcinoma： a clinical analysis of 50 cases[J].journal interventional radiology,2013,(06):381.
[18]赵 松,陈学春,龙清云,等. 经肝动脉化疗栓塞联合射频消融治疗肝细胞癌疗效荟萃分析[J].介入放射学杂志,2013,(11):908.
　ZHAO Song,CHEN Xue? chun,LONG Qing? yun,et al. Transcatheter arterial chemoembolization combined with radiofrequency ablation for the treatment of hepatocellular carcinoma： a systematic review and Meta analysis[J].journal interventional radiology,2013,(06):908.
[19]易长虹,袁琳波,钱 坤,等.肝动脉灌注3-溴丙酮酸阻断大鼠肝癌能量代谢的实验研究[J].介入放射学杂志,2013,(12):1027.
　YI Chang? hong,YUAN Lin? bo,QIAN Kun,et al. Hepatic arterial infusion of 3?蛳 bromopyruvate to block up the energy metabolism of hepatic carcinoma： an experimental study in rats[J].journal interventional radiology,2013,(06):1027.
[20]韩聚强,范公忍,任永强,等. 不同微创介入治疗原发性肝癌对机体T细胞免疫功能的影响[J].介入放射学杂志,2014,(03):218.
　HAN Ju? qiang,FAN Gong? ren,REN Yong? qiang,et al. The influence of different micro?蛳 injury interventional treatments on the T lymphocyte immune function in patients with primary hepatocellular carcinoma[J].journal interventional radiology,2014,(06):218.

备注/Memo

备注/Memo:
 （收稿日期：２０１2-11-19）
更新日期/Last Update: