[1]沈海洋,刘瑞宝,刘 岩,等. 肝右叶前、后段原发性肝癌TACE后VEGF及CD34的表达水平 ；[J].介入放射学杂志,2012,(06):469-472.
　SHEN Hai- yang,LIU Rui- bao,LIU Yan,et al. The expression levels of vascular endothelial growth factor and CD34 in residual cancerous tissues of primary hepatocellular carcinoma located at anterior and posterior segments of right lobe liver after TACE[J].journal interventional radiology,2012,(06):469-472.
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 肝右叶前、后段原发性肝癌TACE后VEGF及CD34的表达水平 ；()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年06期
页码:
469-472
栏目:
肿瘤介入
出版日期:
2012-06-30

文章信息/Info

Title:
 The expression levels of vascular endothelial growth factor and CD34 in residual cancerous tissues of primary hepatocellular carcinoma located at anterior and posterior segments of right lobe liver after TACE
作者:
 沈海洋;  刘瑞宝;  刘 岩;  杨 奕;  孙厚宾;  王惠文;  李 凯
Author(s):
 SHEN Hai- yang;  LIU Rui- bao;  LIU Yan;  YANG Yi;  SUN Hou- bin;  WANG Hui- wen;  LI Kai.
 Department of Interventional Radiology， Tumor Hospital Affiliated to Harbin Medical University， Haerbin 150081， China
关键词:
 ; 【关键词】 肝细胞癌;  经导管动脉化疗栓塞;  肝段;  血管内皮生长因子;  微血管密度
文献标志码:
A
摘要:
 【摘要】 目的 探讨肝右叶后段原发性肝癌病灶较前段易发生侧支循环的可能机制。方法 取经导管肝动脉化疗栓塞术﹙TACE﹚后手术切除的肝细胞癌组织标本57份和未经任何治疗直接手术切除的肝细胞癌组织标本40份（单纯手术组），按影像学检查符合筛选标准31例分两组。A组：13例，病灶位于肝右叶前段（Ⅴ、Ⅷ段）；B组：18例，病灶位于肝右后段（Ⅵ、Ⅶ段﹚。采用免疫组化联酶卵白素染色（SP）法，检测残癌组织血管内皮生长因子﹙VEGF﹚表达水平和微血管密度［MVD（CD34标记）］。结果 TACE组VEGF蛋白阳性表达率显著高于单纯手术组，分别为86.0%和65.0%，差异有统计学意义（P = 0.015）；TACE组MVD值较单纯手术组显著增高，分别为79.37 ± 15.36和43.23 ± 14.98，差异有统计学意义（P = 0.000）。TACE组VEGF蛋白阳性表达与MVD值变化呈正相关（rs = 0.493，P ＜ 0.01）。B组病灶周围MVD略高于A组，分别为80.44 ± 13.74和78.08 ± 15.33，但差异无统计学意义（P ＞ 0.05）。结论 TACE诱导的新生血管生成理论可能并非肝右叶前后段病灶侧支循环建立差异的机制。

参考文献/References:

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 （收稿日期：２０１１-12-2０）
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