[1]胡永进,杜学明,许建辉,等.125Ⅰ粒子植入联合长春瑞滨加顺铂方案治疗纵隔肿瘤压迫性中心气道狭窄的疗效观察[J].介入放射学杂志,2012,(03):228-231.
 ,,et al.CTguided 125Ⅰ seeds implantation combined with NP chemotherapy for the treatment of intractable central airway stenosis caused by NSCLC [J].journal interventional radiology,2012,(03):228-231.
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125Ⅰ粒子植入联合长春瑞滨加顺铂方案治疗纵隔肿瘤压迫性中心气道狭窄的疗效观察 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年03期
页码:
228-231
栏目:
非血管介入
出版日期:
2012-03-28

文章信息/Info

Title:
CTguided 125Ⅰ seeds implantation combined with NP chemotherapy for the treatment of intractable central airway stenosis caused by NSCLC  
作者:
 胡永进 杜学明 许建辉 吴春娃
Author(s):
 HU Yongjin DU Xueming XU Jianhui WU Chunwa.  
 Xinji Municipal Hospital of Traditional Chinese Medicine, Xinji City, Hebei Province 052360, China
关键词:
 【关键词】   纵隔肿瘤 气道狭窄 125Ⅰ粒子 术中植入 队列研究
文献标志码:
A
摘要:
 【摘要】 目的   探讨125Ⅰ粒子植入联合长春瑞滨联合顺铂(NP)化疗治疗纵隔型非小细胞肺癌(NSCLC)压迫所致中心性气道狭窄的临床价值。方法 天津北辰医院肿瘤介入科前瞻性队列研究,入组时间为2004年1月至2010年3月。80例患者随机分为治疗组(42例)依据治疗计划,采用CT引导下单针椎形分布、处方剂量(PD) = 80 ~ 100 GY植入125Ⅰ粒子,源强0.8 mCi,术后CT扫描,并进行治疗计划系统(TPS)评估,验证治疗计划。3 d后给予长春瑞滨(NVB)联合顺铂(DDP)静脉化疗,对照组(38例)单纯应用NVB联合DDP静脉化疗,药物剂量与治疗组参考标准相同,化疗2个周期后观察两组患者气道最狭窄处横截面积及评估呼吸困难指数的变化情况。结果 术后2个月随访,随访率100%。治疗组患者治疗前气道狭窄率为47.82% ± 17.55%,125Ⅰ粒子植入术 + 2个周期化疗后气道狭窄率为15.76% ± 4.65%,患者气道通畅,呼吸困难改善明显,术后气道横截面积改变与呼吸困难指数改善与术前存在明 显差异(P < 0.05)。对照组患者治疗前气道狭窄率为46.24% ± 16.83%, 2个周期化疗后气道狭窄率为40.15% ± 5.08%,气道横截面积改变与呼吸困难指数改善无明显差异(P > 0.05)。结论 125Ⅰ粒子植入联合化疗治疗纵隔型NSCLC压迫所致中心性气道狭窄是一种迅速、有效的治疗方法。

参考文献/References:

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备注/Memo

备注/Memo:
 (收稿日期:20110730)
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