[1]樊济海,顾秀莲,巢胜吾,等.选择性急性肺血管栓塞实验模型的建立[J].介入放射学杂志,2010,(08):639-641.
　FAN Jihai,GU Xiulian,CHAO Shengwu,et al.Establishment of selected acute pulmonary thromboembolism model in experimental sheep[J].journal interventional radiology,2010,(08):639-641.
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选择性急性肺血管栓塞实验模型的建立()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年08期
页码:
639-641
栏目:
实验研究
出版日期:
2010-08-15

文章信息/Info

Title:
Establishment of selected acute pulmonary thromboembolism model in experimental sheep
作者:
樊济海; 顾秀莲; 巢胜吾; 等
２０００５２上海中国人民解放军第四五五医院心内科
Author(s):
FAN Ji－hai; GU Xiu－lian; CHAO Sheng－wu; ZHANG Peng; PAN Rui－lin; WANG Li－na; WANG Lu－lu; WANG Ling; LI Bo ; CHEN Tao－tao．
No．４５５Hospital of PLA，Shanghai２０００５２，China
关键词:
肺血栓栓塞症; 肺栓塞; 动物模型; 导管插入术; 绵羊
分类号:
R－３３２
文献标志码:
B
摘要:
目的建立绵羊急性肺血栓栓塞（APTE）模型。方法实验用绵羊１０只，采用Seldinger血管穿刺技术，建立股静脉和股动脉导管通路，在C型臂数字减影X线透视下，将导管插入肺动脉，将羊自体血栓注入选择的肺动脉分支，监测肺动脉造影，肺动脉压力、股动脉压力、心率、PaO ２ 等指标评估肺栓塞模型的建立。结果基础肺动脉压力（２７．３±９．６）mmHg ，股动脉收缩压（１２６．４±１３．７）mmHg ，心率（１０３±１５）次／min，股动脉血PaO ２ （８７．７±１２．０）mmHg ，n＝１０；注入血栓剂量（３０±５）ml 后６０min，肺动脉压力（５２±４９）mmHg ；股动脉收缩压（１００±２１）mmHg ；心率（１５０±２６）次／min；股动脉血PaO ２ （６２．４±１１．１）mmHg ，P均＜０．０１；肺动脉造影显示选择的肺动脉栓塞成功。结论实验绵羊股静脉、腔静脉系统及右心系统解剖学特征适合于建立导管通路，建立选择性急性肺栓塞模型；建立选择性绵羊急性肺栓塞实验模型可行性、稳定性良好，具有栓塞部位、范围、严重程度的可控制性，影像学特征更适合于急性肺栓塞的实验研究。

参考文献/References:

［１］中华医学心血管分会肺血管组，中国医师协会心血管内科医师分会，急性肺血栓栓塞诊断治疗中国专家共识［J］．中华内科杂志，２０１０，４９：７４－８１．
［２］周小慧，董小黎．肺栓塞实验动物模型的制备及其进展［J］．实验动物科学与管理，２００５，２２：４０－４７．
［３］季颖群，高鹤立，张中和．家兔自体血凝块制作肺栓塞模型的探讨［J］．实验动物科学与管理，２００１，１８：１－４．
［４］Soe JB，Im JG，Goo JM，et al．Comparison of contrast－enhanced CT and gadolinium－enhanced MR anjiography in detection of subsegmental－sized pulmonary embolism．An experimental study in a pig model［J］．Acta Radiol，２００３，４４：４０３－４１０．
［５］Screaton J，Coxson HO，Kaloger SE，et al．Detection of lung perfusion abnormorlities using computed tomography in a porcine model of pulmonary embolism［J］．J Thorac Imaging，２００３，１８：１４－２０．
［６］李建军，翟仁友，张东波，等．犬肺栓塞缺血－再灌注损伤模型的实验研究［J］．介入放射学杂志，２００９，１８：４０－４３．
［７］许俊堂，袁训芝，黄永麟，等．犬急性肺动脉栓塞模型的建立［J］．基础医学与临床，１９９７，１７：７７－７９．
［８］崔宝奎，钟梅．实验性肺栓塞模型的制备［J］．医学综述，２００３，９：２２０－２２１．
［９］Verma RK，Pfeffer JG，Stopinsky T，et al．Evaluation of a newly developed percutaneous thrombectomy basket device in sheep with central pulmonary embolisms ［J］．Invest Radiol，２００６，４１：７２９－７３４．
［１０］Schmitz－Rode T，Verma R，Pfeffer JG．Temporary pulmonary stent placement as emergency treatment of pulmonary embolism．first experimental evaluation［J］．J Am Coll Cardiol，２００６，４８：８１２－８１６．

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备注/Memo

备注/Memo:
收稿日期：２０１０－０３－０１
基金项目：上海市长宁区卫生局局级课题（编号：２００７４Y１６００１）
更新日期/Last Update: 2010-08-15