[1]朱悦琦,李明华,谢剑,等.Willis覆膜支架治疗犬颈内动脉虹吸段动脉瘤的影像学和组织病理学研究[J].介入放射学杂志,2010,(04):302.
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Willis覆膜支架治疗犬颈内动脉虹吸段动脉瘤的影像学和组织病理学研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年04期
页码:
302
栏目:
实验研究
出版日期:
2010-04-15

文章信息/Info

Title:
Treatment of carotid-siphon aneurysms by using Willis stent-graft:an angiographic and histopathologic study in dogs
作者:
朱悦琦李明华谢剑
200233上海交通大学医学院附属第六人民医院放射科(朱悦琦、李明华、谢剑、谭华桥、王建波);上海同济大学医学院附属第十人民医院放射科(程英升)
Author(s):
ZHU Yue-qi LI Ming-huaXIE JianTAN Hua-qiaoCHENG Ying-shengWANG Jian-bo
the Affiliated Sixth People 's Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai200233,China
关键词:
覆膜支架颅内动脉瘤动物模型颈动脉虹吸段
分类号:
R543.4
摘要:
目的建立一种犬颈动脉虹吸段(CS)动脉瘤模型,并观察12个月以测试新型Willis颅内覆膜支架系统的机械性能;评价植入支架在弯曲段血管内的组织学反应。方法通过外科手术方法建立12只犬24枚颈动脉直段侧壁囊性动脉瘤(A组),和12只犬12枚CS动脉瘤(B组)。每枚动脉瘤行1枚覆膜支架植入治疗。以血管造影方法评价支架植入即刻,1、3、6和12个月随访动脉瘤闭塞、支架内漏、支架成角、载瘤动脉是否通畅及再狭窄率等情况。支架段血管行光镜和扫描电镜检查,评价动脉瘤腔内血栓形成,内膜增生和内皮化情况。结果B组中,支架植入即刻血管造影显示2枚动脉瘤存在轻度内漏,3枚支架存在轻度成角现象;12个月时随访,内漏均消失,1支载瘤动脉发生闭塞,3支载瘤动脉有轻度狭窄(<50%)。A组中,1支载瘤动脉闭塞,2支载瘤动脉轻度狭窄(<50%)。电镜检查所有支架内均有新生内膜形成,动脉瘤腔内均充满血栓。B组动物,12个月时才完成完全内皮化过程,内皮细胞排列与血流动力学方向具有很强的相关性。结论应用Willis覆膜支架治疗犬CS动脉瘤方法学上可行。与直段血管相比,弯曲段血管内覆膜支架植入后,支架内皮化时间延长。

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备注/Memo

备注/Memo:
收稿日期:2010-01-26
更新日期/Last Update: 2010-04-15