[1]胡小波,曹建民,许健,等.氩氦刀联合支气管动脉灌注治疗中晚期非小细胞性肺癌的疗效评估[J].介入放射学杂志,2009,(07):503.
　HU Xiaobo,CAO Jianmin,XU Jian,et al.Argon－helium cryoablation combined with bronchial artery infusion for the treatment of advanced non－small cell lung carcinoma[J].journal interventional radiology,2009,(07):503.
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氩氦刀联合支气管动脉灌注治疗中晚期非小细胞性肺癌的疗效评估()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年07期
页码:
503
栏目:
肿瘤介入
出版日期:
2009-07-15

文章信息/Info

Title:
Argon－helium cryoablation combined with bronchial artery infusion for the treatment of advanced non－small cell lung carcinoma
作者:
胡小波; 曹建民; 许健; 等
２１０００２南京军区南京总医院医学影像科
Author(s):
HU Xiao－bo; CAO Jian－min; XU Jian; LU Guang－ming; CHEN Bo．
Department of Medical Imaging，Nanjing General Hospital of Nanjing Military Command，Nanjing２１０００２，China
关键词:
氩氦刀; CT灌注成像; 非小细胞性肺癌中
分类号:
R７３０.５９
文献标志码:
A
摘要:
目的探讨氩氦刀冷冻消融联合支气管灌注化疗（BAI ）治疗中、晚期非小细胞性肺癌的方法、疗效及临床意义。方法将符合入选的２０例肺癌患者分为A组（单纯氩氦刀组）和B组（氩氦刀联合BAI 组），分别行经皮氩氦刀冷冻治疗及氩氦刀＋BAI 治疗。治疗后４周开始行CT或DSA随访，通过肿瘤区CT值变化、CT灌注成像、实体瘤治疗评价标准及生存期评价两组的临床疗效。生存期分析采用Breslow方法，分别计算中位生存时间并绘制生存期曲线图。结果本研究８０％（１６／２０）的病例冰球覆盖率＞９０％。两组间冰球覆盖率差异无统计学意义（P＞０．０５）。A组CT值变化（１６．７３±９．４３）Hu ，B组（１５．２９±６．９８）Hu ，差异无统计学意义（P＞０．０５）。A、B两组治疗前后BF、BV、PS差异有统计学意义（P＜０．０５），两组间BV差异有统计学（P＜０．０５）。B组疗效优于A组。２０例患者随访期间死亡１０例，生存期７～２０个月，A组中位生存期为９个月，B组为１４个月，两组间差异有统计学意义（P＜０．０５），B组生存率优于A组。结论氩氦刀冷冻联合BAI 治疗直径＞３cm的中、晚期非小细胞肺癌是一种安全、有效的方法，疗效优于单纯氩氦刀。CT灌注成像是评估肺癌氩氦刀冷冻治疗疗效的新手段，具有准确、敏感、直观的优点。

参考文献/References:

［１］Therasse P，Arbuek SG，Eisenhauer EA，et a１．New guidelinesto evaluate the response to treatment in solid tumors［J］．JNCI ，２０００，９２：２０５－２１６．
［２］肖湘生．坚守肺癌介入治疗的阵地［J］．介入放射学杂志，２００８，１７：１５３－１５４．
［３］曹建民，史东宏，许健，等．肝癌的氩氦刀冷冻治疗近期疗效的探讨［J］．介入放射学杂志，２００８，１７：２５８－２６１．

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备注/Memo

备注/Memo:
收稿日期：２００９－０５－２２
更新日期/Last Update: 2009-07-15