[1]蒋逢辰,周水平,陈世园,等.HCC患者围介入期抑郁情况调查及其与血清脑源性神经营养因子的相关性[J].介入放射学杂志,2023,32(11):1106-1109.
 JIANG Fengchen,ZHOU Shuiping,CHEN Shiyuan,et al.Survey of depression in patients with hepatocellular carcinoma during perioperative period of interventional treatment and its correlation with serum BDNF concentration[J].journal interventional radiology,2023,32(11):1106-1109.
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HCC患者围介入期抑郁情况调查及其与血清脑源性神经营养因子的相关性()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年11
页码:
1106-1109
栏目:
临床研究
出版日期:
2023-11-30

文章信息/Info

Title:
Survey of depression in patients with hepatocellular carcinoma during perioperative period of interventional treatment and its correlation with serum BDNF concentration
作者:
蒋逢辰 周水平 陈世园 沈家宝 王庆华 戚龙菊
Author(s):
JIANG Fengchen ZHOU Shuiping CHEN Shiyuan SHEN Jiabao WANG Qinghua QI Longju.
School of Nursing, Medical School of Nantong University, Nantong, Jiangsu Province 226001, China
文献标志码:
A
摘要:
【摘要】 目的 了解接受肝动脉栓塞化疗(transcatheter arterial chemoembolization,TACE)的肝细胞癌(hepatocellular carcinoma,HCC)患者抑郁发生情况及其与血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)表达的相关性。方法 选择2018年1月至2019年12月南通市第三人民医院行TACE治疗的HCC患者303例,采用医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)对HCC患者进行抑郁情况调查,收集患者TACE治疗前1 d血清标本,采用ELISA法检测患者血清BDNF浓度,比较抑郁者与非抑郁者血清BDNF浓度。利用受试者工作特性曲线下面积(AUC)评估血清BDNF浓度对抑郁的诊断价值。对抑郁者随访3个月,再次测定其抑郁评分及血清BDNF浓度且进行相关性分析。结果 303例HCC患者中,抑郁患者183例(60.40%),焦虑患者159例(52.48%)。120例非抑郁患者血清BDNF浓度为(30 040.21±8 481.55) pg/mL,183例抑郁患者血清BDNF浓度为(23 555.55±6 921.10) pg/mL,差异有统计学意义(t=7.286,P<0.05);BDNF的AUC为0.749(95%CI:0.687~0.811,P<0.01),约登指数为0.497,截断值为30 901.62 pg/mL;BDNF浓度越高,HADS- D评分越低,反之BDNF浓度越低,HADS- D评分越高,两者呈线性趋势关系,变化方向相反,Pearson相关系数为- 0.730,相关系数的双侧检验P<0.05。结论 HCC患者围介入期抑郁发生率为60.40%,HCC抑郁患者的BDNF低于非抑郁患者,且BDNF表达量与抑郁评分呈负相关。
【关键词】 肝细胞癌; 肝动脉栓塞化疗; 抑郁; 脑源性神经营养因子

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2022- 05- 27)
(本文编辑:新 宇)
更新日期/Last Update: 2023-11-30