[1]李坤峰,郑 睿,胡章明.CalliSpheres载药栓塞微球加载表柔比星治疗不可切除原发性肝癌的疗效[J].介入放射学杂志,2023,32(02):131-135.
 LI Kunfeng,ZHENG Rui,HU Zhangming..Clinical efficacy of CalliSpheres drug-eluting beads loaded with epirubicin in the treatment of unresectable primary liver cancer[J].journal interventional radiology,2023,32(02):131-135.
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CalliSpheres载药栓塞微球加载表柔比星治疗不可切除原发性肝癌的疗效()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年02
页码:
131-135
栏目:
肿瘤介入
出版日期:
2023-03-03

文章信息/Info

Title:
Clinical efficacy of CalliSpheres drug-eluting beads loaded with epirubicin in the treatment of unresectable primary liver cancer
作者:
李坤峰 郑 睿 胡章明
Author(s):
LI Kunfeng ZHENG Rui HU Zhangming.
Department of Interventional Radiology, Tongling Municipal People’s Hospital, Tongling, Anhui Province 244000, China
关键词:
【关键词】 原发性肝癌经导管动脉化疗栓塞载药微球疗效
文献标志码:
A
摘要:
【摘要】 目的 探讨CalliSpheres载药栓塞微球加载表柔比星在不可切除原发性肝癌(PLC)中的疗效。方法  选取2016年2月至2020年10月铜陵市人民医院收治的104例不可切除PLC患者为研究对象,以随机数字表法分为研究组、对照组,每组各52例。对照组采用常规动脉化疗栓塞(TACE)表柔比星,研究组采用CalliSpheres载药微球加载表柔比星的TACE。治疗后3个月观察效果,并随访12个月。记录患者抗肿瘤疗效、血液肿瘤标志物、肝功能、并发症情况,统计患者预后情况。结果 研究组客观缓解率、临床控制率高于对照组(P<0.05)。治疗后两组患者的甲胎蛋白(AFP)、碱性成纤维细胞生长因子(BFGF)、核因子κB(NF-κB) 均低于治疗前(P<0.05),研究组治疗后的AFP、BFGF 、NF-κB 均低于对照组(P<0.05)。治疗前后两组患者的天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆红素(TBil)、白蛋白(Alb)水平对比差异均无统计学意义(均P>0.05)。两组总不良事件发生率对比差异无统计学意义(P>0.05)。研究组存活33例,对照组存活22例,差异有统计学意义(P<0.05)。结论 CalliSpheres载药栓塞微球加载表柔比星治疗不可切除PLC疗效显著,安全性及预后良好。

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备注/Memo

备注/Memo:
(收稿日期:2022-01-20)
(本文编辑:新 宇)
更新日期/Last Update: 2023-03-03