[1]侯思楠,王卫东,钟泽龙,等.不可逆电穿孔消融术联合PD- 1抑制剂治疗小鼠肝癌效果初步研究[J].介入放射学杂志,2019,28(05):454-458.
 HOU Sinan,WANG Weidong,ZHONG Zelong,et al.The efficacy of irreversible electroporation ablation combined with PD- 1 inhibitor in the treatment of hepatocellular carcinoma in experimental mice: preliminary study[J].journal interventional radiology,2019,28(05):454-458.
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不可逆电穿孔消融术联合PD- 1抑制剂治疗小鼠肝癌效果初步研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
28
期数:
2019年05期
页码:
454-458
栏目:
实验研究
出版日期:
2019-05-25

文章信息/Info

Title:
The efficacy of irreversible electroporation ablation combined with PD- 1 inhibitor in the treatment of hepatocellular carcinoma in experimental mice: preliminary study
作者:
侯思楠 王卫东 钟泽龙 倪嘉延 陈耀庭 许林锋
Author(s):
HOU Sinan WANG Weidong ZHONG Zelong NI Jiayan CHEN Yaoting XU Linfeng.
Department of Interventional Radiology, Sun Yat- sen Memorial Hospital, Sun Yat- sen University, Guangzhou, Guangdong Province 510120, China
关键词:
【关键词】 不可逆电穿孔消融术 PD- 1抑制剂 肝癌 肿瘤微环境
文献标志码:
A
摘要:
【摘要】 目的 探讨不可逆电穿孔(IRE)消融术联合程序性细胞死亡蛋白(PD)- 1抑制剂治疗小鼠肝癌效果及肿瘤微环境变化。方法 构建小鼠皮下肝癌模型,随机分为对照组、IRE组、PD- 1组和IRE联合PD- 1组。采用实时荧光定量聚合酶链反应(PCR)和免疫组化分析不同组别不同时间点肿瘤组织CD8和Foxp3细胞表达,流式细胞学检测外周血T细胞分群,并描绘肿瘤生长曲线。结果 IRE消融术联合PD- 1抑制剂治疗后,小鼠肿瘤体积明显缩小,外周血和肿瘤组织CD8+T细胞表达均增多,调节性T细胞(Treg)水平明显下降。结论 IRE消融术联合PD- 1抑制剂能有效减少肿瘤负荷,引起肿瘤微环境改变,为肝癌消融联合免疫治疗提供了新的方向。

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备注/Memo

备注/Memo:
(收稿日期:2019-01-17)
(本文编辑:边 佶)
更新日期/Last Update: 2019-05-11