[1]尹明,王中阳,肖蔚.超声引导肝癌裸鼠模型瘤体内注入聚桂醇实验研究[J].介入放射学杂志,2016,(06):530-533.
 YIN Ming,WANG Zhong-yang,XIAO Wei.Ultrasound-guided injection of lauromacrogol into liver cancer: an experimental study in nude mouse models [J].journal interventional radiology,2016,(06):530-533.
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超声引导肝癌裸鼠模型瘤体内注入聚桂醇实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年06期
页码:
530-533
栏目:
实验研究
出版日期:
2016-06-25

文章信息/Info

Title:
Ultrasound-guided injection of lauromacrogol into liver cancer: an experimental study in nude mouse models

作者:
尹明王中阳肖蔚
Author(s):
YIN Ming WANG Zhong-yang XIAO Wei
Department of Ultrasound, Taizhou Municipal People’s Hospital,Taizhou, Jiangsu Province 225300, China
关键词:
【关键词】超声介入 聚桂醇 荷瘤鼠 肝癌
文献标志码:
A
摘要:
【摘要】目的对比研究聚桂醇、无水乙醇及生理盐水经超声介入硬化治疗荷瘤肝癌模型的作用效果,探讨聚桂醇能否成为治疗原发性肝癌的新型硬化剂。 方法取BALB/C裸鼠30 只及人肝癌HepG2型细胞系构建裸鼠肝癌模型,将18只造模成功荷瘤裸鼠随机分为聚桂醇组(n=6)、无水乙醇组(n=6)及生理盐水组(n=6),分别向模型瘤体中央部位注入相应药物和生理盐水进行治疗实验,观察原发性肝癌状况;超声测量各组瘤体大小,计算肿瘤生长抑制率,苏木精-伊红染色观察瘤体超声影像学改变,镜下观察肿瘤内部及周围病理学改变。 结果实验鼠造模成功18只,皮下瘤体结节均肉眼可见。聚桂醇组和无水乙醇组肿瘤生长明显受抑制(瘤体缩小,1例完全消失),总有效率100%,肿瘤生长抑制率达77.13%,病理学检查见肿瘤组织大片坏死,细胞核固缩;生理盐水组瘤体体积随时间增加无缓解。 结论聚桂醇可抑制BALB/C裸鼠原发性肝癌模型,达到与无水乙醇相似的近期硬化效果,有望成为治疗肝癌的理想硬化剂。


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备注/Memo

备注/Memo:
(收稿日期:2015-08-17)


(本文编辑:边佶)
更新日期/Last Update: 2016-06-21