[1]伦俊杰,赵俊玲,孙建业,等.CT引导下125I放射性粒子植入联合化疗对中晚期胰腺癌的疗效 [J].介入放射学杂志,2015,(06):494-497.
 LUN Jun- jie,ZHAO Jun- ling,SUN Jian- ye,et al.CT- guided 125I radioactive seed interstitial implantation combined with chemotherapy for advanced pancreatic carcinoma: analysis of therapeutic efficacy[J].journal interventional radiology,2015,(06):494-497.
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CT引导下125I放射性粒子植入联合化疗对中晚期胰腺癌的疗效 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年06期
页码:
494-497
栏目:
肿瘤介入
出版日期:
2015-06-25

文章信息/Info

Title:
CT- guided 125I radioactive seed interstitial implantation combined with chemotherapy for advanced pancreatic carcinoma: analysis of therapeutic efficacy
作者:
伦俊杰 赵俊玲 孙建业 胡效坤 殷好治
Author(s):
LUN Jun- jie ZHAO Jun- ling SUN Jian- ye HU Xiao- kun YIN Hao- zhi
Department of Oncology, Changle County People’s Hospital, Weifang, Shandong Province 262400, China
关键词:
【关键词】 胰腺癌 125I粒子 吉西他滨 替吉奥
文献标志码:
A
摘要:
【摘要】 目的 探讨CT引导下125I放射性粒子植入联合吉西他滨和替吉奥(GS)化疗方案治疗中晚期胰腺癌的疗效及安全性。方法 将68例无手术指征的中晚期胰腺癌患者随机分为两组。A组38例接受125I粒子植入联合GS化疗方案,B组30例接受GS化疗方案。比较两组近期疗效、中位无进展生存时间(mPFS)、中位生存时间(mOS)和不良反应。结果 A组客观有效率、疾病控制率和临床受益率(ORR、DCR和CBR)分别为57.9%、73.7%、84.2%,B组分别为26.7%、46.7%、60.0%,两组比较差异均有统计学意义(P<0.05);A组mPFS、mOS分别为8.0、11.8个月,高于B组5.6、10.4个月,差异有统计学意义(P<0.05);消化道反应、血液毒性及肝毒性等不良反应,差异无统计学意义(P>0.05)。结论 对于中晚期胰腺癌患者,CT引导下125I放射性粒子植入联合GS方案是一种安全、有效的治疗手段。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2014 -10- 30)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2015-06-24