[1]李虎子,郭 志,王海涛,等.肝细胞癌患者TACE后外周血调节性T细胞水平对预后的影响[J].介入放射学杂志,2012,(12):998-1001.
　LI Hu? zi,GUO Zhi,WANG Hai? tao,et al. The effect of regulatory T cells level in peripheral blood on the prognosis in HCC patients after TACE [J].journal interventional radiology,2012,(12):998-1001.
点击复制

肝细胞癌患者TACE后外周血调节性T细胞水平对预后的影响 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年12期
页码:
998-1001
栏目:
肿瘤介入
出版日期:
2012-12-25

文章信息/Info

Title:
 The effect of regulatory T cells level in peripheral blood on the prognosis in HCC patients after TACE
作者:
 李虎子;  郭 志;  王海涛;  司同国;  刘长富;  于海鹏
Author(s):
 LI Hu?蛳 zi;  GUO Zhi;  WANG Hai?蛳 tao;  SI Tong?蛳 guo;  LIU Chang?蛳 fu;  YU Hai?蛳 peng.
 Department of Interventional Radiology， Affiliated Cancer Hospital of Tianjin Medical University， Tianjin 300060， China
关键词:
 ; 【关键词】 原发性肝癌;  调节性T细胞;  免疫功能;  预后
文献标志码:
A
摘要:
 【摘要】 目的 探讨肝细胞癌（HCC）患者TACE治疗后外周血调节性T细胞（Treg）水平与预后的关系。方法 回顾性分析天津医科大学附属肿瘤医院收治的122例HCC患者经TACE治疗后外周血中Treg占CD4+ T细胞比例与生存时间（OS）的关联。结果 HCC患者TACE后Treg细胞占CD4+ T细胞的比率显著升高（分别为6.109 和 6.834，P = 0.000）；低Treg组（< 6.7）HCC患者中位生存期19.3个月，高Treg组（≥ 6.7）中位生存期12个月，两组间OS存在显著差异。结论 HCC患者TACE治疗后外周血Treg水平是判断预后的独立预测指标。

参考文献/References:

 ［1］ Zou W. Regulatory T cells， tumour immunity and immunotherapy［J］. Nat Rev Immunol， 2006， 6： 295 ?蛳 307.
［2］ Sasaki A， Tanaka F， Mimori K， et al. Prognostic value of tumor?蛳 infiltrating FOXP3+ regulatory T cells in patients with hepatocell?蛳 ular carcinoma［J］. Eur J Surg Oncol， 2008， 34： 173 ?蛳 179.
［3］ Zhou L， Fu J， Lu Y， et al. Regulatory T cells are associated with post?蛳 cryoablation prognosis in patients with hepatitis B virus?蛳 related hepatocellular carcinoma［J］. J Gastroenterol， 2010， 45： 968 ?蛳 978.
［4］ Xiong B， Feng G， Luo S， et al. Changes of CD4（+） CD25 （+） regulatory T cells in peripheral blood in patients with hepatocellular carcinoma before and after TACE［J］. J Huazhong Univ Sci Technolog Med Sci， 2008， 28： 645 ?蛳 648.
［5］ Wang HY， Wang RF. Regulatory T cells and Cancer［J］. Curr Opin Immunol， 2007， 19： 217 ?蛳 223.
［6］ Huang B， Pan P， Li Q， et al. Gr?蛳 1+CD115+ immature myeloid suppressor cells mediate the development of tumor?蛳 induced T regulatory cells and T?蛳 cell anergy in tumor?蛳 bearing host［J］. Cancer Res， 2006， 66： 1123 ?蛳 1131.
［7］ 樊永丽， 于津浦， 李 慧， 等． 原发性肝癌患者调节性T细胞与预后的关系［J］． 中国肿瘤临床， 2011， 38： 442 ?蛳 446．
［8］ Brown DB， Nikolic B， Covey AM， et al. Quality improvement guidelines for transhepatic arterial chemoembolization， emboliza?蛳 tion， and chemotherapeutic infusion for hepatic malignancy［J］. J Vasc Interv Radiol， 2012， 23： 287 ?蛳 294.
［9］ Gao Q， Qiu S， Fan J， et al. Intratumoral balance of regulatory and cytotoxic T cell is associated with prognosis of hepatocellular carcinoma after resection［J］. J Clin Oncol， 2007， 25： 2586 ?蛳 2593.
［10］ Roncarolo MG， Gregori S， Battaglia M， et al. Interleukin?蛳 10?蛳 secreting type 1 regulatory T cells in rodents and humans［J］. Immunol Rev， 2006， 212： 28 ?蛳 50.
［11］ Lan RY， Mackay IR， Gershwin ME. Regulatory T cells in the prevention of mucosal inflammatory diseases： patrolling the border［J］. J Autoimmun， 2007， 29： 272 ?蛳 280.
［12］ Xiu HuaYang， Yamagiwa S， Ichida T， et al. Increase of CD4+CD25+ regulatory T?蛳 cells in the liver of patients with hepatocellular carcinoma［J］. J Hepatol， 2006， 45： 245 ?蛳 262.
［13］ Elkord E， Alcantar?蛳 Orozco EM， Dovedi SJ， et al. T regulatory cells in cancer： recent advances and therapeutic potential［J］. Expert Opin Biol Ther， 2010， 10： 1573 ?蛳 1586.
［14］ Griffiths RW， Eikord E， Gilham DE， et al. Frequency of regulatory T cell in renal cell carcinoma patients and investigation of correlation with survival［J］. Cancer Immunol Immunother， 2007， 56： 1743 ?蛳 1753.
［15］ 郭 志， 邢文阁， 刘 方， 等． 氩氦冷冻在原发巨块型肝癌介入治疗中的临床应用［J］． 中华放射学杂志， 2005， 39： 198 ?蛳 203．
［16］ 杨 茂， 郭 志， 司同国， 等． 动脉化疗栓塞联合CIK细胞过继免疫治疗对中晚期肝癌患者免疫功能的影响［J］． 介入放射学杂志， 2011， 20： 116 ?蛳 119．

相似文献/References:

[1].Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].介入放射学杂志,2007,(10):718.
　ZHANG He,LI Ming-hua,WANG Chun,et al.Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].journal interventional radiology,2007,(12):718.
[2]李统怀,郑红枫. 子宫动脉栓塞治疗子宫瘢痕妊娠１１例[J].介入放射学杂志,2011,(11):898.
　LI Tong-huai,ZHENG Hong-feng..Clinical application of uterine artery embolization in treating uterine scar pregnancy[J].journal interventional radiology,2011,(12):898.
[3]吕维富,张爱武,周春泽,等. 子宫动脉的三维DSA表现及其最佳显示体位探讨[J].介入放射学杂志,2011,(11):853.
　LV Wei-fu,ZHANG Ai-wu,ZHOU Chun-ze,et al.3D-DSA findings of uterine artery and its optimal projection position[J].journal interventional radiology,2011,(12):853.
[4]张 靖,周少毅,陈昆山,等.经导管动脉硬化栓塞联合注射硬化治疗婴儿颌面部巨大高流量血管瘤[J].介入放射学杂志,2011,(11):848.
　ZHANG Jing,ZHOU Shao-yi,CHEN Kun-shan,et al.Transcatheter arterial sclerosing embolization with injection sclerotherapy for the treatment of huge and high-flow maxillofacial hemangiomas in infants[J].journal interventional radiology,2011,(12):848.
[5]谢小西,吕银祥,章宏欣,等. 肝动脉化疗栓塞、射频消融联合１２５Ⅰ粒子植入 治疗原发性肝癌的临床应用[J].介入放射学杂志,2011,(11):863.
　XIE Xiao-xi,LV Yin-xiang,ZHANG Hong-xin,et al.The clinical application of TACE together with RFA and 125Ⅰ seed implantation in treating hepatocellular carcinoma[J].journal interventional radiology,2011,(12):863.
[6]王铭义,王 峰. 脑灌注成像在颈动脉狭窄介入治疗中的应用[J].介入放射学杂志,2011,(11):915.
　WANG Ming-yi,WANG Feng..Application of brain perfusion imaging in interventional treatment of carotid artery stenosis[J].journal interventional radiology,2011,(12):915.
[7]杜 猛,张锦生. 介入治疗急性深静脉血栓的临床观察[J].介入放射学杂志,2011,(11):858.
　DU Meng,ZHANG Jing-sheng..Interventional therapy for acute deep venous thrombosis: a clinical observation[J].journal interventional radiology,2011,(12):858.
[8]孟庆娜,李国庆,白晓冬. 急性心肌梗死介入治疗术中恶心呕吐的护理[J].介入放射学杂志,2011,(11):913.
　MENG Qing-na,LI Guo-qing,BAI Xiao-dong..The nursing care of nausea and vomiting occurred in interventional treatment for acute myocardial infarction[J].journal interventional radiology,2011,(12):913.
[9]王海亭,蒋忠仆,周 毅,等. 透视引导下鱼肝油酸钠泡沫硬化剂治疗下肢静脉曲张３０例[J].介入放射学杂志,2011,(11):905.
　WANG Hai-ting,JIANG Zhong-pu,ZHOU Yi,et al.Fluoroscopically-guided foam sclerotherapy with sodium morrhuate for the treatment of lower extremity varices[J].journal interventional radiology,2011,(12):905.
[10]杜 鲲,管 生,胡小波,等. 原发性肝癌ＴＡＣＥ术后完全缓解病灶磁共振 ＡＤＣ值可重复性及一致性研究[J].介入放射学杂志,2011,(11):867.
　DU Kun,GUAN Sheng,HU Xiao-bo,et al.Magnetic resonance apparent diffusion coefficient values of the completely remitted lesions of primary hepatocellular carcinoma after TACE: a study of their repeatability and consistency[J].journal interventional radiology,2011,(12):867.
[11]程洪涛,郭晨阳,黎海亮,等.ＴＡＣＥ联合射频消融治疗原发性肝癌疗效的影响因素分析[J].介入放射学杂志,2012,(03):216.
　,,et al.ＴＡＣＥ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ＣＴｇｕｉｄｅｄ ｐｅｒｃｕｔａｎｅｏｕｓ ｒａｄｉｏｆｒｅｑｕｅｎｃｙ ａｂｌａｔｉｏｎ ｆｏｒ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｐｒｉｍａｒｙ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ： ａｎ ａｎａｌｙｓｉｓ ｏｆ ｆａｃｔｏｒｓ ａｆｆｅｃｔｉｎｇ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｒｅｓｕｌｔ [J].journal interventional radiology,2012,(12):216.
[12]张晓前,郭 鹏,党之俊,等.金龙胶囊联合介入疗法治疗原发性肝癌临床观察[J].介入放射学杂志,2012,(03):249.
　,,et al.Ｋｉｎｇｌｏｎｇ ｃａｐｓｕｌｅｓ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｉｎｔｅｒｖｅｎｔｉｏｎａｌ ｔｈｅｒａｐｙ ｆｏｒ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ： ｃｌｉｎｉｃａｌ ｏｂｓｅｒｖａｔｉｏｎ [J].journal interventional radiology,2012,(12):249.
[13]姚红响,陈根生,诸葛英,等.肝动脉化疗栓塞联合ＣＴ引导射频消融序贯治疗中小肝癌的临床应用[J].介入放射学杂志,2012,(04):301.
　,,et al.Ｓｅｑｕｅｎｔｉａｌ ｔｒｅａｔｍｅｎｔ ｗｉｔｈ ＴＡＣＥ ａｎｄ ＣＴｇｕｉｄｅｄ ＲＦＡ ｆｏｒ ｓｍａｌｌ ａｎｄ ｍｏｄｅｒａｔｅ ｓｉｚｅｄ ＨＣＣ [J].journal interventional radiology,2012,(12):301.
[14]姚全军,胡鸿涛,黎海亮,等.Ｃ臂ＣＴ成像在乏血供原发性肝癌诊疗中的临床应用[J].介入放射学杂志,2012,(04):305.
　,,et al.Ｔｈｅ ｃｌｉｎｉｃａｌ ａｐｐｌｉｃａｔｉｏｎ ｏｆ Ｃ ａｒｍ ＣＴ ｉｍａｇｉｎｇ ｉｎ ｄｉａｇｎｏｓｉｎｇ ａｎｄ ｔｒｅａｔｉｎｇ ｈｙｐｏｖａｓｃｕｌａｒ ｐｒｉｍａｒｙ ｈｅｐａｔｉｃ ｃａｒｃｉｎｏｍａｓ [J].journal interventional radiology,2012,(12):305.
[15]高 嵩,朱旭,杨仁杰,等. ＴＡＣＥ联合奥沙利铂、氟尿嘧啶、亚叶酸钙肝动脉化疗治疗中晚期原发性肝癌[J].介入放射学杂志,2012,(05):377.
　,,et al. ＴＡＣＥ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｈｅｐａｔｉｃ ａｒｔｅｒｉａｌ ｉｎｆｕｓｉｏｎ ｃｈｅｍｏｔｈｅｒａｐｙ ｕｓｉｎｇ ｏｘａｌｉｐｌａｔｉｎ， ５ｆｌｕｏｒｏｕｒａｃｉｌ ａｎｄ ｆｏｌｉｎｉｃ ａｃｉｄ ｆｏｒ ｉｎｔｅｒｍｅｄｉａｔｅ ａｎｄ ａｄｖａｎｃｅｄ ｈｅｐａｔｏｃｅｌｌｕｌａｒ ｃａｒｃｉｎｏｍａｓ[J].journal interventional radiology,2012,(12):377.
[16]刘 昕,吕维富,鲁 东,等. 动脉介入栓塞治疗肝癌破裂出血[J].介入放射学杂志,2012,(07):586.
　LIU Xin,LV Wei- fu,LU Dong,et al. Interventional treatment of hepatic bleeding due to spontaneous rupture of hepatocellular carcinoma[J].journal interventional radiology,2012,(12):586.
[17]张志良,杨学东,温阿明,等. 经动脉化疗栓塞联合伽玛刀治疗原发性肝癌的疗效评价[J].介入放射学杂志,2012,(07):596.
　ZHANG Zhi- liang,YANG Xue- dong,WEN A-ming,et al. Evaluation of TACE combined with gamma?蛳 knife radiotherapy for primary hepatocellular carcinoma[J].journal interventional radiology,2012,(12):596.
[18]赵许亚,周 石.TACE联合经皮瘤内注射碘油吡柔比星乳剂治疗中晚期肝癌疗效分析[J].介入放射学杂志,2012,(08):675.
　ZHAO Xu- ya,ZHOU Shi.. Transcatheter artery chemoembolization combined with percutaneous intratumoral injection of Lipiodol emulsion of pirarubicin for advanced hepatocellular carcinomas： an analysis of clinical efficacy[J].journal interventional radiology,2012,(12):675.
[19]王少雷,李 森,魏 宏,等.奥沙利铂与吡喃阿霉素介入治疗原发性肝癌的比较研究[J].介入放射学杂志,2012,(09):738.
　WANG Shao- lei,LI Sen,WEI Hong,et al. Interventional chemoembolization therapy of primary hepatocellular carcinoma： a comparative study between oxaliplatin and therarubicin[J].journal interventional radiology,2012,(12):738.
[20]陶超超,张鸿文,吴纪瑞. 原发性肝癌TACE术后肺部炎症的影像表现及原因分析[J].介入放射学杂志,2012,(12):1038.
　TAO Chao? chao,ZHANG Hong? wen,WU Ji? rui.. Pulmonary inflammation occurring after TACE for primary hepatocellular carcinoma： its imaging features and an analysis of its causes[J].journal interventional radiology,2012,(12):1038.

备注/Memo

备注/Memo:
 （收稿日期：２０１2?鄄０7?鄄27）
更新日期/Last Update: