[1]张学彬,花迎雪,仇晓霞,等. 肝动脉臭氧化碘油栓塞治疗兔VX2肝癌的初步研究[J].介入放射学杂志,2012,(09):760-764.
　ZHANG Xue- bin,HUA Ying-xue,QIU Xiao- xia,et al. A preliminary study of hepatic arterial embolization with ozonated?蛳 Lipiodol for liver VX2 carcinoma in experimental rabbits[J].journal interventional radiology,2012,(09):760-764.
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 肝动脉臭氧化碘油栓塞治疗兔VX2肝癌的初步研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年09期
页码:
760-764
栏目:
实验研究
出版日期:
2012-09-30

文章信息/Info

Title:
 A preliminary study of hepatic arterial embolization with ozonated?蛳 Lipiodol for liver VX2 carcinoma in experimental rabbits
作者:
 张学彬;  花迎雪;  仇晓霞;  张冰星;  路 青;  沈加林;  许建荣
Author(s):
 ZHANG Xue- bin;  HUA Ying-xue;  QIU Xiao- xia;  ZHANG Bin- xing;  LU Qin;  SHENG Jia- lin;  XU Jian-rong.
 Department of Interventional Radiology， Renji Hospital， School of Medicine， Shanghai Jiaotong University， Shanghai 200127， China
关键词:
 ; 【关键词】 肝肿瘤;  臭氧化碘油;  动脉栓塞;  动物实验
文献标志码:
A
摘要:
 【摘要】 目的 探索肝动脉臭氧化碘油栓塞治疗新西兰大白兔VX2肝癌的安全性及疗效。方法 将碘化油经臭氧化2 h后备用。兔VX2肝癌模型21只，采用MRI或CT增强扫描确定肿瘤存在并测量肿瘤大小。将实验兔随机分成经肝动脉臭氧化碘油栓塞组（A组）、经肝动脉碘化油栓塞组（B组）、假手术组（C组），每组7只。治疗1周后检测血清中丙氨酸转氨酶、天冬氨酸转氨酶、白细胞和总抗氧化能力水平；治疗后每2周行CT和MRI复查，评价相对肿瘤体积，并观察组间生存期及并发症差异。结果 所有动物完成相应治疗操作。处理后28 d，A、B、C组相对肿瘤体积分别为1.39 ± 1.48，7.21 ± 5.50，12.2 ± 7.12，三组间差异有统计学意义（χ2 = 10.71， P = 0.005），A组和B组间差异亦有统计学意义（χ2 = 7.00， P = 0.03）。A、B及C组平均生存时间分别为（87.14 ± 9.72）d、（56.14 ± 6.81）d和（46.43 ± 6.13）d。生存分析曲线显示A组累计生存率明显高于B组和C组。结论 初步研究表明肝动脉内臭氧化碘油栓塞与单纯碘油栓塞相比可有效抑制兔VX2肿瘤生长，延长荷瘤兔生存期。

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 （收稿日期：2012-02-18）
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