[1]梁俊生,贺能树,吴胜勇,等.川芎嗪对犬血管成形术局部血栓形成的影响[J].介入放射学杂志,1997,(04):216-218+222.
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川芎嗪对犬血管成形术局部血栓形成的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
1997年04期
页码:
216-218+222
栏目:
实验研究
出版日期:
2000-01-01

文章信息/Info

作者:
梁俊生;贺能树;吴胜勇;
承德解放军第二六六医院;  天津医科大学总医院放射科 067000
关键词:
血管成形术 川芎嗪 血栓
摘要:
了解川芎嗪对预防 PTA 后血栓形成的影响。选用10条实验性肾动脉狭窄犬,随机分为对照组和实验组,每组5条。实验组 PTRA 前15日开始静滴川芎嗪注射液,40mg/kg。实验组于给药前、PTRA 前及术后4小时,对照组于 PTRA 前和术后4小时分别采集外周静脉血,作血小板聚集、TXB2和6-酮-PGF测定。PTRA后4小时将犬处死,处死前切取成形侧肾动脉,测量 PTRA 局部血栓体积。结果显示:川芎嗪可显著抑制血小板聚集和血小板 TXA2的产生,明显增加血管内皮合成释放 PGI2,显著阻止 PTRA 局部血栓的形成。表明川芎嗪是一种有效预防 PTA 后血栓闭塞性再狭窄的药物。

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更新日期/Last Update: 1900-01-01