[1]吴瑕,徐克,肖亮,等.血管内支架构型变化对血流动力学及支架内再狭窄形成的影响[J].介入放射学杂志,2009,(04):297.
 WU Xia,XU Ke,XIAO Liang,et al.The effect of stent structure changes on the hemodynamics and the formation of in-stent restenosis[J].journal interventional radiology,2009,(04):297.
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血管内支架构型变化对血流动力学及支架内再狭窄形成的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年04期
页码:
297
栏目:
实验研究
出版日期:
2009-04-15

文章信息/Info

Title:
The effect of stent structure changes on the hemodynamics and the formation of in-stent restenosis
作者:
吴瑕徐克肖亮
110001沈阳中国医科大学附属第一医院放射科
Author(s):
WU XiaXU Ke XIAO LiangZHANG Xi-tongSU Hong-yingFENG Bo
Department of Radiology,the First Affiliated Hospital,China Medical University,Shenyang110001,China
关键词:
支架血流动力学再狭窄计算流体动力学
分类号:
R543
文献标志码:
B
摘要:
目的研究血管内支架的构型变化对血管壁面剪切力、血流速度及流动方式的作用,探讨支架构型对于支架内再狭窄形成的影响。方法应用三维实体建模软件Pro /engineer wildfire3.0建立5种支架模型,其中A为对照组,B加入横向连接结构,C加入纵向连接结构,D的支架厚度为A的2倍,E的网格密度为A的2倍,将其导入计算流体动力学(computational fluid dynamics,CFD)软件Ansys11.0-CFX,建立流体模型。设定边界条件后进行计算流体动力学分析,比较不同构型的支架植入后引起的血管壁面剪切力、管腔内血流速度及流动方式的变化。结果支架模型A、B、C、D、E植入后血管壁面低剪切力区域所占比率分别为:7.78%、6.65%、1.48%、16.52%、12.12%,D、E的低剪切力区域比率明显大于A,B的低剪切力区域比率明显小于A。支架横截面流速矢量(velocity vector)图显示,D、E中的血流低流速涡流区明显大于A,C中低流速涡流区明显小于A。结论支架构型变化能够引起植入血管血流动力学的明显改变,支架厚度和(或)网格密度增加是引起低剪切力区形成的主要因素,能够促进支架内再狭窄的发生,在支架中加入纵向连接结构能明显减少低剪切力区,可以降低再狭窄形成概率。

参考文献/References:

[1]James E,Moore JR,Joel LB.Fluid and solid mechanical implications of vascular stenting[J].Ann Biomed Eng,2002,30:498-508.
[2]Andreas OF,Peter WW,James EM.Computational fluid dynamics and stent design[J].Art Org,2002,26:614-621.
[3]Frank AO,Wals

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备注/Memo

备注/Memo:
收稿日期:2008-10-06
基金项目:国家科技支撑计划课题(编号:2007BAI05B04)
更新日期/Last Update: 2009-04-15