[1]王革芳,程永德,王咏梅,等.静脉滴注重组人血管内皮抑素联合动脉灌注化疗治疗晚期恶性肿瘤的临床观察[J].介入放射学杂志,2009,(04):270.
 WANG Gefang,CHENG Yongde,WANG Yongmei,et al.Intravenous drip transfusion of recombinant human endostatin combined with arterial infusion chemotherapy for the treatment of advanced carcinomas:a clinical observation[J].journal interventional radiology,2009,(04):270.
点击复制

静脉滴注重组人血管内皮抑素联合动脉灌注化疗治疗晚期恶性肿瘤的临床观察()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年04期
页码:
270
栏目:
肿瘤介入
出版日期:
2009-04-15

文章信息/Info

Title:
Intravenous drip transfusion of recombinant human endostatin combined with arterial infusion chemotherapy for the treatment of advanced carcinomas:a clinical observation
作者:
王革芳程永德王咏梅
200052上海解放军第八五医院内一科
Author(s):
WANG Ge-fangCHENG Yong-deWANG Yong-meiDU Ai-minMAO YongLU Hai-yuJIANG Cheng-yuanLU Hai-zhouWANG Lei.
No.1Department of Internal Medicine,No.85Hospital of PLA,Shanghai200052,China
关键词:
重组人血管内皮抑素动脉灌注化疗晚期恶性肿瘤抗肿瘤血管形成
分类号:
R730.51
文献标志码:
A
摘要:
目的探讨静脉滴注重组人血管内皮抑素联合动脉灌注化疗治疗晚期恶性肿瘤的疗效及安全性。方法选取41例晚期恶性肿瘤患者入组研究,分为治疗组和对照组,均给予相应的肿瘤供血动脉灌注化疗,治疗组在灌注化疗后当天开始给予重组人血管内皮抑素静脉滴注治疗,连用14d,间隔7d为1个周期,对照组仅行动脉灌注化疗治疗,于2个治疗周期后比较疗效和生活质量评分,同时比较不良反应。结果重组人血管内皮抑素治疗组治疗后疾病控制率、K氏评分显著升高,差异有统计学意义(P<0.05);有效率和不良反应与对照组差异无统计学意义(P>0.05)。结论采用静脉滴注重组人血管内皮抑素联合动脉灌注化疗治疗晚期恶性肿瘤,患者的疾病控制率和生活质量有明显的提高,而治疗相关不良反应不大,值得临床推广及进一步研究。

参考文献/References:

[1]Kim YM,Hwang S,Kim YM,et al,Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1[J].J Biol Chem,2002,277:27872-27879.
[2]Hajitou A,Grignet C,Devy L,et al,The antitumoral effect of endostatin

相似文献/References:

[1]许立超,李文涛.乳腺癌介入治疗指南的建议[J].介入放射学杂志,2010,(06):425.
 XU Lichao,LI Wentao.Suggestions about the guidelines for interventional therapy of breast cancer[J].journal interventional radiology,2010,(04):425.
[2]谢其康,李焕祥,张西,等.动脉灌注化疗对有无肝转移的进展期胃癌疗效的比较[J].介入放射学杂志,1995,(03):144.
[3]刘瑞宝,杨光,崔亚利,等.125I粒子植入联合动脉灌注化疗治疗不可切除性肺癌[J].介入放射学杂志,2009,(06):453.
 LIU Rui-bao,YANG Guang,CUI Ya-li,et al.Evaluation of125I seed implantation combined with arterial infusion chemotherapy in treating unresectable lung cancer[J].journal interventional radiology,2009,(04):453.
[4]吉效东,张学新,曹金凤,等.中晚期食管癌的动脉灌注化疗及其风险浅评[J].介入放射学杂志,1996,(02):101.
[5]程永德.动脉灌注化疗并栓塞治疗肝癌的若干问题[J].介入放射学杂志,1999,(04):186.
[6]黄坤林,刘玉金.肺癌介入治疗临床研究进展[J].介入放射学杂志,2019,28(10):1005.
 HUANG Kunlin,LIU Yujin..Recent progress in clinical application of interventional therapy for lung cancer[J].journal interventional radiology,2019,28(04):1005.

备注/Memo

备注/Memo:
收稿日期:2008-10-28
更新日期/Last Update: 2009-04-15