[1]李智 倪才方 董凤林 肖荣 刘航 刘一之 金泳海 沈健.兔VX2肝癌模型的建立及其生长转移特性的观察[J].介入放射学杂志,2009,(09):691.
LI Zhi NI Cai-fang DONG Feng-lin XIAO Rong LIU Hang LIU Yi-zhi JIN Yong-hai SHEN Jian.The establishment of VX2 hepatic carcinoma model in rabbits and the observation of its growing and metastatic characteristics[J].journal interventional radiology,2009,(09):691.
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兔VX2肝癌模型的建立及其生长转移特性的观察(
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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- 期数:
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2009年09期
- 页码:
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691
- 栏目:
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实验研究
- 出版日期:
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2009-09-15
文章信息/Info
- Title:
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The establishment of VX2 hepatic carcinoma model in rabbits and the observation of its growing and metastatic characteristics
- 作者:
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李智 倪才方 董凤林 肖荣 刘航 刘一之 金泳海 沈健
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李智,倪才方,肖荣,刘一之,金泳海,沈健,LI Zhi,NI Cai-fang,XIAO Rong,LIU Yi-zhi,JIN Yong-hai,SHEN Jian(苏州大学附属第一医院介入科,215006)
董凤林,DONG Feng-lin(苏州大学附属第一医院超声科,215006)
刘航,LIU Hang(苏州大学附属第一医院核医学科,215006)
- Author(s):
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LI Zhi NI Cai-fang DONG Feng-lin XIAO Rong LIU Hang LIU Yi-zhi JIN Yong-hai SHEN Jian
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- 关键词:
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肝肿瘤 VX2肿瘤细胞 动物模型 生物学特性 hepatic carcinoma VX2 tumor cell animal model biological characteristics
- 分类号:
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R73-354
- 摘要:
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目的 探讨超声引导下经皮穿刺瘤块推送法建立兔VX2肝癌模型的可行性,评估开展介入治疗实验研究的最佳时期.方法 28只新西兰大白兔接受VX2瘤块接种,接种后2、3、4 周行超声检查及PET/CT榆查,并分别处死2只建模成功的动物行病理检查.结果 建模成功率为89.3%(25/28).接种后2、3、4周肿瘤最大径分别为(4.82±0.80)mm、(16.05±2.89)mm、(30.08±5.38)mm,转移率分别为0(0/25)、13.0%(3/23)、76.2%(16/21);接种后2周肿瘤生长旺盛,无明显坏死,3周仅有少量点片状凝固性坏死,4周见大片坏死.结论 超声引导下经皮穿刺瘤块推送法建立兔VX2肝癌模型简单易行,成功率高;宜在接种后第3周开展介入治疗的实验研究.
参考文献/References:
1.Shope RE.Hurst EW Infection papillomatosis of rabbits:with a note on the histopathology 1933
2.刘险峰.任乐荣.苏广彦 兔VX2肿瘤细胞系的建立及其生物学特性的观察 2005(10)
3.van Es RJ.Dullens H F.van der Bilt A Evaluation of the VX2 rabbit auricle carcinoma as a model for head and neck cancer in humans 2000
4.Sapundzhiev N.Dunne AA.Ramaswamy A The auricular VX2 carcinoma:feasibilitu of complete tumor resection 2005
5.Schulz S.Haussler U.Mandic R treatment with ozone/ oxygen-pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas 2008
6.Gupta T.Virmani S.Neidt TM MR tracking of ironlabeled glass radioembolization microspheres during transcatheter delivery to rabbit VX2 liver tumors:feasibility study 2008
7.Mostafa EM.Ganguli S.Faintuch S Optimal strategies for combining transcatheter arterial chemoembolization and radiofrequency ablation in rabbit VX2 hepatic tumor 2008
8.Morimoto K.Sakaguchi H.Tanaka T Transarterial chemoembolization using cisplatin powder in a rabbit model of liver cancer 2008
9.彭玉萍.戴社教.郭万亮 兔VX2移植性肝癌模型的制作及影像学评价 2008
10.Chen JH.Lin YC.Huang YS Induction of VX2 carcinoma in rabbit liver:comparison of two inoculation methods 2004
11.陈珑.倪才方.白霞 不同移植方式建立兔VX2肝癌模型 2007
12.Lin WY.Chen J.Lin Y Implantation of VX2 carcinoma into the liver of rabbits:a comparison of three direct-injection methods 2002
13.Lee KH.Liapi E.Buijs M Considerations for implantation site of VX2 carcinoma into rabbit liver 2009
14.史东宏.曹建民.许建 CT引导下兔VX2肝癌模型的制作及综合评估 2008
15.胡军.刘志苏.唐胜利 兔VX2肝癌模型种植方法的改良及其长特性的研究 2007
16.王志明.任正刚.叶彤 兔肝VX2肝肿瘤模型的转移特性 2006
备注/Memo
- 备注/Memo:
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基金项目：江苏省科教兴卫工程医学重点人才基金
更新日期/Last Update:
2009-09-15