[1]宗登伟,孟艳莉,张东阳,等.经导管动脉化疗栓塞联合氩氦冷冻消融治疗富血供小肝细胞癌临床效果[J].介入放射学杂志,2025,34(08):840-846.[doi:10.3969/j.issn.1008-794X.2025.08.007 ]
 ZONG Dengwei,MEMG Yanli,ZHANG Dong yang,et al.Transcatheter arterial chemoembolization combined with argon-helium cryoablation for the treatment of hypervascular small hepatocellular carcinoma:analysis of its clinical efficacy[J].J Intervent Med,2025,34(08):840-846.[doi:10.3969/j.issn.1008-794X.2025.08.007 ]
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经导管动脉化疗栓塞联合氩氦冷冻消融治疗富血供小肝细胞癌临床效果 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
34
期数:
2025年08
页码:
840-846
栏目:
肿瘤介入
出版日期:
2025-08-25

文章信息/Info

Title:
Transcatheter arterial chemoembolization combined with argon-helium cryoablation for the treatment of hypervascular small hepatocellular carcinoma:analysis of its clinical efficacy
文章编号:
1008-794X(2025)-008-0840-07
作者:
宗登伟 孟艳莉 张东阳 肖金成 李 靖
450008 河南郑州 郑州大学附属肿瘤医院(河南省肿瘤医院)微创介入科
Author(s):
ZONG DengweiMEMG YanliZHANG Dong yangXIAO JinchengLI Jing.
Department of Minimally-Invasive Intervention,Affiliated Cancer Hospital of Zhengzhou University(Henan Provincial Cancer Hospital),Zhengzhou,Henan Province 450008,China
关键词:
小肝细胞癌 经导管动脉化疗栓塞 氩氦冷冻消融 肝功能 免疫功能
分类号:
R735.7
DOI:
10.3969/j.issn.1008-794X.2025.08.007
文献标志码:
A
摘要:
目的 探讨经导管动脉化疗栓塞(TACE)联合氩氦冷冻消融(AHC)治疗富血供小肝细胞癌(sHCC)的临床效果。方法 回顾性分析2018年3月至2019年2月在郑州大学附属肿瘤医院接受TACE联合AHC治疗的35例富血供sHCC患者临床资料。均先行TACE,3~7 d后行AHC。评价术后1、3、6个月疗效,1、3、5年生存率。检测肝功能、免疫功能指标及血清肿瘤标志物,记录治疗期间不良反应。结果 术后1、3、6个月总缓解率(ORR)分别为100.00%、94.29%、91.43%,疾病控制率(DCR)分别为100.00%、100.00%、97.14%。总生存期(OS)为(46.54±2.88)个月,1、3、5年生存率分别为94.29%(33/35)、65.71%(23/35)、48.57(17/35)。术后3 d患者血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBil)水平与术前相比显著增加(均 P <0.001),术后2周恢复至术前水平( P >0.05)。术后2周患者CD4+%、CD4+/CD8+水平与术前相比显著增高(均 P <0.05),CD8+%水平显著降低( P <0.05)。术后2周患者甲胎蛋白(AFP)、甲胎蛋白异质体比率(AFP-L3%)、脱-γ-羧基凝血酶原(DCP)、磷脂酰肌醇蛋白聚糖(GPC)3水平均较术前显著降低(均 P <0.001)。术后患者均未出现治疗相关严重并发症。结论 TACE联合AHC治疗富血供sHCC临床效果良好,安全性高。

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(收稿日期:2024-11-28)
(本文编辑:谷 珂)

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备注/Memo

备注/Memo:
基金项目: 河南省医学科技攻关计划项目(LHGJ202202213)
通信作者: 宗登伟 E-mail:dengwzz@126.com
更新日期/Last Update: 2025-08-25