[1]孟雪柔,潘文秋,赵 卫,等.TEG- PM与药物相关基因检测指导颅内动脉瘤支架植入后抗血小板聚集治疗的应用价值[J].介入放射学杂志,2023,32(07):627-631.
 MENG Xuerou,PAN Wenqiu,ZHAO Wei,et al.Clinical application value of TEG- PM and drug- related genetic testing in guiding against platelet aggregation therapy after stent implantation for intracranial aneurysms[J].journal interventional radiology,2023,32(07):627-631.
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TEG- PM与药物相关基因检测指导颅内动脉瘤支架植入后抗血小板聚集治疗的应用价值()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年07
页码:
627-631
栏目:
神经介入
出版日期:
2023-07-31

文章信息/Info

Title:
Clinical application value of TEG- PM and drug- related genetic testing in guiding against platelet aggregation therapy after stent implantation for intracranial aneurysms
作者:
孟雪柔 潘文秋 赵 卫 易根发 李 刚 赵芝敏 张晓东
Author(s):
MENG Xuerou PAN Wenqiu ZHAO Wei YI Genfa LI Gang ZHAO Zhimin ZHANG Xiaodong.
Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China
关键词:
【关键词】 颅内动脉瘤 血栓弹力图血小板图 血小板内皮聚集受体1基因 细胞色素 P 450 酶 2 C 19基因 抗血小板聚集治疗
文献标志码:
A
摘要:
【摘要】 目的 探讨颅内动脉瘤患者行支架植入术后分别在血栓弹力图血小板图(thromboelasto- graphy- platelet mapping,TEG- PM)检测与药物相关抵抗基因检测指导下的抗血小板聚集治疗用药的安全性及有效性。方法 纳入2021年1月至2022年8月昆明医科大学第一附属医院收治的颅内动脉瘤患者65例,所有患者均行阿司匹林及氯吡格雷相关基因检测,并于服用抗血小板药物后行TEG- PM。将患者随机分为A组33例,B组32例。A组在药物相关基因检测指导下行抗血小板聚集治疗,B组在TEG- PM指导下行抗血小板聚集用药。比较两组术后缺血性并发症及出血性并发症发生率。结果 缺血性并发症B组0例,A组2例(RR=0.492,95%CI:0.383~0.632,χ2=0.485,P=0.468),A组2例患者分别于用药后3.4个月及1.6个月出现缺血性并发症。出血性并发症A组1例,B组3例(RR=0.302,95%CI:0.303~3.069,χ2=0.300,P=0.584);A组中1例患者于术后4.33个月出现牙龈出血,B组3例患者中,2例于术后2.2个月及1.6个月无明显诱因出现皮肤散在片状青紫, 1例于术后2.3个月出现黑便,完善相关检查发现消化道溃疡。结论 颅内动脉瘤行支架植入术后在TEG- PM及药物相关基因检测下指导抗血小板聚集治疗安全可行,临床应用时应据患者个体化选择,并检测其指标变化,及时调整用药。

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备注/Memo

备注/Memo:
(收稿日期:2022- 11- 22)
(本文编辑:新 宇)
更新日期/Last Update: 2023-07-31