[1]王晓锋,张立新,张晓乐.长链非编码RNA肺腺癌转移相关转录因子1表达水平与颅内动脉瘤血管内治疗后复发的关系研究[J].介入放射学杂志,2021,30(11):1157-1161.
　WANG Xiaofeng,ZHANG Lixin,ZHANG Xiaole..The correlation between the expression level of lncRNA MALAT1 and the recurrence in patients with intracranial aneurysm after endovascular embolization[J].journal interventional radiology,2021,30(11):1157-1161.
点击复制

长链非编码RNA肺腺癌转移相关转录因子1表达水平与颅内动脉瘤血管内治疗后复发的关系研究()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
30
期数:
2021年11
页码:
1157-1161
栏目:
临床研究
出版日期:
2021-11-25

文章信息/Info

Title:
The correlation between the expression level of lncRNA MALAT1 and the recurrence in patients with intracranial aneurysm after endovascular embolization
作者:
王晓锋;  张立新;  张晓乐
Author(s):
WANG Xiaofeng;  ZHANG Lixin;  ZHANG Xiaole.
Department of Neurosurgery， Hangzhou Municipal Ninth People’s Hospital， Hangzhou， Zhejiang Province 311225， China
关键词:
【关键词】 颅内动脉瘤;  长链非编码RNA;  肺腺癌转移相关转录因子1;  复发
文献标志码:
A
摘要:
【摘要】 目的 探讨颅内动脉瘤患者血管内栓塞治疗后长链非编码RNA（lncRNA）肺腺癌转移相关转录因子（MALAT）1表达水平与复发的关系。 方法 选取2016年3月至2018年9月在杭州市第九人民医院就诊的168例颅内动脉瘤患者作为研究对象，根据血管内栓塞治疗2年内颅内动脉瘤是否复发分为复发组（n=31）和未复发组（n=137）。采用实时荧光定量聚合酶链反应（PCR）法检测lncRNA MALAT1表达水平，并分析其与复发的关系。 结果 复发组术前和术后lncRNA MALAT1表达水平均高于未复发组，差异均有统计学意义（P＜0.05）；1∶1倾向性评分匹配后，复发组术后lncRNA MALAT1表达水平高于未复发组，差异有统计学意义（P＜0.05）。logistic回归分析结果显示，动脉瘤颈、Raymond分级、术后lncRNA MALAT1均为颅内动脉瘤患者血管内栓塞治疗后复发的独立风险因素（P＜0.05）。限制性立方样条拟合logistic回归分析结果显示，术后lncRNA MALAT1与颅内动脉瘤患者血管内栓塞治疗后复发呈线性关系。 结论 颅内动脉瘤患者血管内栓塞治疗后lncRNA MALAT1表达水平降低。术后低lncRNA MALAT1提示颅内动脉瘤患者血管内栓塞治疗后复发风险低。

参考文献/References:

［1］ 李淦诚，张 炘，范海燕，等． 支架辅助弹簧圈栓塞颅内破裂动脉瘤临床分析［J］． 介入放射学杂志， 2020， 29：439- 443．
［2］ Zhou B， He Y， Cheng J， et al. Treatment of the acute thrombo-embolic event during endovascular embolization of intracranial aneurysm［J］. J Intervent Med， 2020， 3： 208- 212.
［3］ 方治军，张 东． 颅内动脉瘤介入栓塞术后二次复发的影响因素分析［J］． 中华解剖与临床杂志， 2019， 24：375- 379．
［4］ Campi A， Ramzi N， Molyneux AJ， et al. Retreatment of ruptured cerebral aneurysms in patients randomized by coiling or clipping in the International Subarachnoid Aneurysm Trial（ISAT）［J］. Stroke， 2007， 38： 1538- 1544.
［5］ Wang W， Li H， Yu L， et al. Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm［J］. Oncotarget， 2017， 8： 2477- 2484.
［6］ Sun Y， Wen Y， Ruan Q， et al. Exploring the association of long noncoding RNA expression profiles with intracranial aneurysms， based on sequencing and related bioinformatics analysis［J］. BMC Med Genomics， 2020， 13： 147.
［7］ Wu C， Song H， Wang Y， et al. Long non- coding RNA TCONS_00000200 as a non- invasive biomarker in patients with intracranial aneurysm［J］. Biosci Rep， 2019， 39： BSR20182224.
［8］ Gao G， Zhang Y， Yu J， et al. Long non- coding RNA MALAT1/microRNA- 143/VEGFA signal axis modulates vascular endothelial injury- induced intracranial aneurysm［J］. Nanoscale Res Lett， 2020， 15： 139.
［9］ Fan C， Yuan Q， Liu G， et al. Long non- coding RNA MALAT1 regulates oxaliplatin- resistance via miR- 324- 3p/Adam17 axis in colorectal cancer cells［J］. Cancer Cell Int， 2020， 20： 473.
［10］ Liu X， Zhao W， Wang X. Inhibition of long non- coding RNA MALAT1 elevates microRNA- 429 to suppress the progression of hypopharyngeal squamous cell carcinoma by reducing ZEB1［J］. Life Sci， 2020， 262： 118480.
［11］ Li L， Xu Y， Zhao M， et al. Neuro- protective roles of long non- coding RNA MALAT1 in Alzheimer’s disease with the involvement of the microRNA- 30b/CNR1 network and the following PI3K/AKT activation［J］. Exp Mol Pathol， 2020， 117： 104545.
［12］ Nakamura M， Montibeller GR， Gotz F， et al. Microsurgical clipping of previously coiled intracranial aneurysms［J］. Clin Neurol Neurosurg， 2013， 115： 1343- 1349.
［13］ Wang HW， Sun ZH， Wu C， et al. Surgical management of recurrent aneurysms after coiling treatment［J］. Br J Neurosurg， 2017， 31： 96- 100.
［14］ Mascitelli JR， Moyle H， Oermann EK， et al. An update to the Raymond- Roy Occlusion Classification of intracranial aneurysms treated with coil embolization［J］. J Neurointerv Surg， 2015， 7： 496- 502.
［15］ 李立群，胡劲松． 血管内栓塞术治疗颅内动脉瘤术后复发的影响因素分析［J］． 海南医学， 2017， 28：1156- 1158．
［16］ 王 驰，曹 伟，左 乔，等． 颅内动脉瘤血管内栓塞术后复发的影响因素分析［J］． 中国脑血管病杂志， 2016， 13：113- 117．
［17］ 成红学，张小喜，黄宝和． 颅内动脉瘤血管内栓塞术后复发影响因素的单中心分析［J］． 河南医学研究， 2019， 28：3526- 3528．
［18］ 童俊江，康俊龙，田新华． 介入栓塞术后复发颅内动脉瘤的治疗研究进展［J］． 中华神经外科杂志， 2020， 36：316- 317．
［19］ Molyneux AJ， Kerr RS， Yu LM， et al. International subarachnoid aneurysm trial（ISAT） of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms： a randomised comparison of effects on survival， dependency， seizures， rebleeding， subgroups， and aneurysm occlusion［J］. Lancet， 2005， 366： 809- 817.

相似文献/References:

[1]邢 鸣,杨鹏飞,黄清海,等.支架治疗颈内动脉分叉部宽颈动脉瘤[J].介入放射学杂志,2012,(02):92.
　XING Ming,YANG Peng-fei,HUANG Qing-hai,et al.Stent implantation for the treatment of wide-necked aneurysms located at internal carotid artery bifurcation[J].journal interventional radiology,2012,(11):92.
[2]黄海东,顾建文,杨春敏,等.Enterprise支架辅助弹簧圈栓塞治疗前交通宽颈动脉瘤的临床研究[J].介入放射学杂志,2012,(07):536.
　HUANG Hai- dong,GU Jian- wen,YANG Chun-min,et al. Enterprise stent- assisted coil embolization for wide?蛳 necked anterior communicating artery aneurysms： a clinical study[J].journal interventional radiology,2012,(11):536.
[3]陆 靖,李永东,李明华,等. 时间飞越法磁共振血管造影对蛛网膜下腔出血诊断和治疗的临床价值[J].介入放射学杂志,2012,(09):711.
　LU Jing,LI Yong- dong,LI Ming- hua,et al. The clinical value of time- of-flight MRA in diagnosing and treating subarachnoid haemorrhage[J].journal interventional radiology,2012,(11):711.
[4]田红岸,赵 卫,易根发. 动脉灌注替罗非班在处理颅内动脉瘤栓塞术中急性血栓栓塞的研究[J].介入放射学杂志,2012,(09):718.
　TIAN Hong- an,ZHAO Wei,YI Geng-fa.. Application of intra- arterial infusion of tirofiban in dealing with acute thromboembolism occurred during embolization therapy for intracranial aneurysms： a preliminary study[J].journal interventional radiology,2012,(11):718.
[5]陈 状,李 林,王伟民,等. SolitaireAB支架结合弹簧圈治疗颅内宽颈动脉瘤的初步经验[J].介入放射学杂志,2013,(06):447.
　CHEN Zhuang,LI Lin,WANG Wei? min,et al. SolitaireAB stent- assisted coiling of intracranial wide- necked aneurysms： preliminary experience[J].journal interventional radiology,2013,(11):447.
[6]田红岸,赵 卫,易根发. 颅内动脉瘤内支架辅助治疗的并发症分析[J].介入放射学杂志,2012,(11):885.
　TIAN Hong- an,ZHAO Wei,YI Geng- fa.. Endovascular stent- assited management for the treatment of intracranial aneurysms： an analysis of complications[J].journal interventional radiology,2012,(11):885.
[7]温宏峰,赵春霞,李继来,等. 双微导管技术栓塞颅内宽颈不规则动脉瘤[J].介入放射学杂志,2012,(11):890.
　WEN Hong- feng,ZHAO Cun- xia,LI Ji- lai,et al. Double microcatheter technique for detachable coil treatment of wide?蛳 necked and irregular intracranial aneurysms[J].journal interventional radiology,2012,(11):890.
[8]崔艳峰,徐 浩,祖茂衡,等. Solitaire AB支架在辅助栓塞颅内宽颈动脉瘤中的临床应用[J].介入放射学杂志,2013,(08):617.
　CUl Yan? feng,XU Hao,ZU Mao? heng,et al. Clinical application of Solitaire AB stent in assisting coiling embolization for intracranial wide?蛳 necked aneurysms[J].journal interventional radiology,2013,(11):617.
[9]郄福忠,马光涛,王玖飞,等.大脑中动脉分叉部动脉瘤的血管内介入治疗[J].介入放射学杂志,2014,(08):655.
　QIE Fu zhong,MA Guang tao,WANG Jiu fei,et al.Endovascular interventional embolization for the treatment of aneurysms located at the bifurcation of middle cerebral artery[J].journal interventional radiology,2014,(11):655.
[10]程少容,曾晓华,王 鹰,等.320排动态容积CT血管造影对颅内动脉瘤手术前后评估的研究[J].介入放射学杂志,2013,(10):793.
　CHENG Shao? rong,ZENG Xiao? hua,WANG Ying,et al. Application of 320?蛳 detector dynamic volume CT angiography in evaluating preoperative and postoperative intracranial aneurysms[J].journal interventional radiology,2013,(11):793.

备注/Memo

备注/Memo:
（收稿日期：2021- 03- 01）
（本文编辑：边 佶）
更新日期/Last Update: 2021-11-22