[1]孟艳莉,黎海亮,赵 妍,等.CT导向下125I粒子植入联合髂内动脉化疗灌注治疗难治性复发性盆腔恶性肿瘤疗效评价 [J].介入放射学杂志,2017,(12):1114-1117.
 MENG Yanli,LI Hailiang,ZHAO Yan,et al.CT- guided 125I particle implantation combined with iliac artery infusion chemotherapy for refractory and recurrent pelvic malignant tumors: evaluation of its curative effect[J].journal interventional radiology,2017,(12):1114-1117.
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CT导向下125I粒子植入联合髂内动脉化疗灌注治疗难治性复发性盆腔恶性肿瘤疗效评价
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年12期
页码:
1114-1117
栏目:
临床研究
出版日期:
2017-12-25

文章信息/Info

Title:
CT- guided 125I particle implantation combined with iliac artery infusion chemotherapy for refractory and recurrent pelvic malignant tumors: evaluation of its curative effect
作者:
孟艳莉 黎海亮 赵 妍 郭晨阳 宗登伟 余 朴
Author(s):
MENG Yanli LI Hailiang ZHAO Yan GUO Chenyang ZONG Dengwei YU Pu
Department of Interventional Radiology, Henan Provincial Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province 450008, China
关键词:
【关键词】 125I粒子 CT引导 化疗灌注 盆腔恶性肿瘤
文献标志码:
A
摘要:
【摘要】 目的 探讨CT导向下125I粒子植入联合髂内动脉化疗灌注治疗难治性复发性盆腔恶性肿瘤的临床疗效。方法 选自2013年1月至2016年1月采用CT导向下125I粒子植入联合髂内动脉化疗灌注治疗难治性复发性盆腔恶性肿瘤35例患者为治疗组,与单纯采用125I粒子植入治疗的该类患者39例为对照组,对两组的近、远期疗效和临床症状改善进行比较。结果 治疗组客观有效率60.0%(21/35),获益率85.7%(30/35);对照组客观有效率53.8%(21/39),获益率84.6%(33/39),两组客观有效率及获益率差异均无统计学意义(P=0.594,P=0.894);治疗组疾病无进展期平均12.2个月,对照组平均8.6个月,治疗组较对照组平均间隔时间延长了3.6个月,两组差异有统计学意义(P=0.002);治疗组复发率40.0%(12/30),对照组57.6%(19/33),两组比较差异有显著统计学意义(P=0.018)。治疗组治疗前后KPS平均值为72.4分和82.7分,对照组为68.9分和79.1分,各组治疗前后临床症状改善差异有统计学意义(P=0.043,P=0.039),两组治疗后临床症状改善差异无统计学意义(P=0.745)。结论 对难治性复发性盆腔恶性肿瘤采用125I粒子植入是一种有效的治疗方案,但联合髂内动脉化疗灌注可以降低肿瘤复发,提高疾病无进展期。

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备注/Memo

备注/Memo:
(收稿日期:2016-09-02)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2017-12-24