[1]徐晓林,朱争艳,经 翔.肝细胞癌患者射频消融前后的免疫状态研究进展[J].介入放射学杂志,2017,(01):87-91.
　XU Xiao- lin,ZHU Zheng- yan,JING Xiang.The immune state in patients with hepatocellular carcinoma before and after radiofrequency ablation treatment： recent progress in research[J].journal interventional radiology,2017,(01):87-91.
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肝细胞癌患者射频消融前后的免疫状态研究进展 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年01期
页码:
87-91
栏目:
综述
出版日期:
2017-01-25

文章信息/Info

Title:
The immune state in patients with hepatocellular carcinoma before and after radiofrequency ablation treatment： recent progress in research
作者:
徐晓林;  朱争艳;  经 翔
Author(s):
XU Xiao- lin;  ZHU Zheng- yan;  JING Xiang
Third Central Clinical College of Tianjin Medical University， Tianjin 300170， China
关键词:
【关键词】 肝细胞癌;  射频消融;  免疫
文献标志码:
A
摘要:
【摘要】 射频消融（RFA）治疗肝细胞癌（HCC）后，肿瘤细胞发生凝固性坏死与凋亡，产生原位肿瘤抗原，直接或间接激发机体固有免疫及适应性免疫反应，帮助逆转机体免疫抑制状态。本文主要对RFA治疗HCC引起的局部及全身性免疫反应、适应性免疫及固有免疫及其对细胞因子的调节发挥的作用进行综述，进而对RFA治疗HCC后的机体免疫改变进行阐明。

参考文献/References:

［1］ Torre LA， Bray F， Siegel RL， et al. Global cancer statistics， 2012［J］. CA Cancer J Clin， 2015， 65： 87- 108.
［2］ Hatzaras I， Bischof DA， Fahy B， et al. Treatment options and surveillance strategies after therapy for hepatocellular carcinoma［J］. Ann Surg Oncol， 2014， 21： 758- 766.
［3］ Tiong L， Maddern GJ. Systematic review and meta- analysis of survival and disease recurrence after radiofrequency ablation for hepatocellular carcinoma［J］. Br J Surg， 2011， 98： 1210- 1224.
［4］ Nobuoka D， Motomura Y， Shirakawa HA， et al. Radiofrequency ablation for hepatocellular carcinoma induces glypican- 3 peptide- specific cytotoxic T lymphocytes［J］. Int J Oncol， 2012， 40： 63- 70.
［5］ Napoletano C， Taurino F， Biffoni M， et al. RFA strongly modulates the immune system and anti- tumor immune responses in metastatic liver patients［J］. Int J Oncol， 2008， 32： 481- 490.
［6］ Guan HT， Wang J， Yang M， et al. Changes in immunological function after treatment with transarterial chemoembolization plus radiofrequency ablation in hepatocellular carcinoma patients［J］. Chin Med J （Engl）， 2013， 126： 3651- 3655.
［7］ Zerbini A， Pilli M， Penna A， et al. Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor- specific T- cell responses［J］. Cancer Res， 2006， 66： 1139- 1146.
［8］ 韩聚强， 范公忍， 任永强， 等． 不同微创介入治疗原发性肝癌对机体T细胞免疫功能的影响［J］． 介入放射学杂志， 2014， 23： 218- 221．
［9］ Ahmed M， Kumar G， Moussa M， et al. Hepatic radiofrequency ablation- induced stimulation of distant tumor growth is suppressed by c- Met inhibition［J］. Radiology， 2016， 279： 103- 117.
［10］ Rozenblum N， Zeira E， Bulvik B， et al. Radiofrequency ablation： inflammatory changes in the periablative zone can induce global organ effects， including liver regeneration［J］. Radiology， 2015， 276： 416- 425.
［11］ Rozenblum N， Zeira E， Scaiewicz V， et al. Oncogenesis： an “off- target” effect of radiofrequency ablation［J］. Radiology， 2015， 276： 426- 432.
［12］ Chen KJ， Zhou L， Xie HY， et al. Intratumoral regulatory T cells alone or in combination with cytotoxic T cells predict prognosis of hepatocellular carcinoma after resection［J］. Med Oncol， 2012， 29： 1817- 1826.
［13］ Flecken T， Schmidt N， Hild S， et al. Immunodominance and functional alterations of tumor- associated antigen- specific CD8+ T- cell responses in hepatocellular carcinoma［J］. Hepatology， 2014， 59： 1415- 1426.
［14］ Hernandez- Gea V， Toffanin S， Friedman SL， et al. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma［J］. Gastroenterology， 2013， 144： 512- 527.
［15］ Witkowski M， Spangenberg HC， Neumann- Haefelin C， et al. Lack of ex vivo peripheral and intrahepatic α- fetoprotein- specific CD4+ responses in hepatocellular carcinoma［J］. Int J Cancer， 2011， 129： 2171- 2182.
［16］ Fu J， Xu D， Liu Z， et al. Increased regulatory T cells correlate with CD8 T- cell impairment and poor survival in hepatocellular carcinoma patients［J］. Gastroenterology， 2007， 132： 2328- 2339.
［17］ Pedroza- Gonzalez A， Verhoef C， Ijzermans JN， et al. Activated tumor- infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer［J］. Hepatology， 2013， 57： 183- 194.
［18］ Song S， Yuan P， Li P， et al. Dynamic analysis of tumor- associated immune cells in DEN- induced rat hepatocellular carcinoma［J］. Int Immunopharmacol， 2014， 22： 392- 399.
［19］ Huang Y， Wang F， Wang Y， et al. Intrahepatic interleukin- 17+ T cells and FoxP3+ regulatory T cells cooperate to promote development and affect the prognosis of hepatocellular carcinoma［J］. J Gastroenterol Hepatol， 2014， 29： 851- 859.
［20］ Zhang B， Jia H， Liu J， et al. Depletion of regulatory T cells facilitates growth of established tumors： a mechanism involving the regulation of myeloid- derived suppressor cells by lipoxin A4［J］. J Immunol， 2010， 185： 7199- 7206.
［21］ Gao HJ， Zhang YJ， Liang HH， et al. Radiofrequency ablation does not induce the significant increase of CD4+ CD25+ Foxp3+ regulatory T cells compared with surgical resection in Hepal- 6 tumor model［J］. Arch Immunol Ther Exp （Warsz）， 2013， 61： 333- 340.
［22］ Kakumu S， Ito S， Ishikawa T， et al. Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection［J］. J Gastroenterol Hepatol， 2000， 15： 431- 436.
［23］ Kitahara M， Mizukoshi E， Nakamoto Y， et al. Efficient generation of highly immunocompetent dendritic cells from peripheral blood of patients with hepatitis C virus- related hepatocellular carcinoma［J］. Int Immunopharmacol， 2014， 21： 346- 353.
［24］ Pardee AD， Shi J， Butterfield LH. Tumor- derived α- fetoprotein impairs the differentiation and T cell stimulatory activity of human dendritic cells［J］. J Immunol， 2014， 193： 5723- 5732.
［25］ Dromi SA， Walsh MP， Herby S， et al. Radiofrequency ablation induces antigen- presenting cell infiltration and amplification of weak tumor- induced immunity［J］. Radiology， 2009， 251： 58- 66.
［26］ 戴维德， 范智慧， 陈敏华， 等． 正常大鼠肝脏射频消融前后外周血树突状细胞的变化及意义［J］． 中国介入影像与治疗学， 2006， 3： 137- 140．
［27］ 范智慧， 陈敏华， 戴维德， 等． 射频消融治疗前后大鼠树突状细胞的变化［J］． 中国医学影像技术， 2006， 22： 1143- 1146．
［28］ Zerbini A， Pilli M， Fagnoni F， et al. Increased immunostimulatory activity conferred to antigen- presenting cells by exposure to antigen extract from hepatocellular carcinoma after radiofrequency thermal ablation［J］. J Immunother， 2008， 31： 271- 282.
［29］ Ali MY， Grimm CF， Ritter M， et al. Activation of dendritic cells by local ablation of hepatocellular carcinoma［J］. J Hepatol， 2005， 43： 817- 822.
［30］ Sha WH， Zeng XH， Min L. The correlation between NK cell and liver function in patients with primary hepatocellular carcinoma［J］. Gut Liver， 2014， 8： 298- 305.
［31］ Cheung PF， Yip CW， Ng LW， et al. Restoration of natural killer activity in hepatocellular carcinoma by treatment with antibody against granulin- epithelin precursor［J］. Oncoimmunology， 2015， 4： e1016706.
［32］ Ramzan M， Sturm N， Decaens T， et al. Liver- infiltrating CD8+ lymphocytes as prognostic factor for tumour recurrence in hepatitis C virus- related hepatocellular carcinoma［J］. Liver Int， 2016， 36： 434- 444.
［33］ Mao Y， Sarhan D， Steven A， et al. Inhibition of tumor- derived prostaglandin- e2 blocks the induction of myeloid- derived suppres- sor cells and recovers natural killer cell activity［J］. Clin Cancer Res， 2014， 20： 4096- 4106.
［34］ Jang JW， Oh BS， Kwon JH， et al. Serum interleukin- 6 and C- reactive protein as a prognostic indicator in hepatocellular carcinoma［J］. Cytokine， 2012， 60： 686- 693.
［35］ Lee IC， Huang YH， Chau GY， et al. Serum interferon gamma level predicts recurrence in hepatocellular carcinoma patients after curative treatments［J］. Int J Cancer， 2013， 133： 2895- 2902.
［36］ Wubetu GY， Utsunomiya T， Ishikawa D， et al. High STAT4 expression is a better prognostic indicator in patients with hepatocellular carcinoma after hepatectomy［J］. Ann Surg Oncol， 2014， 21： S721- S728.
［37］ Kao JT， Feng CL， Yu CJ， et al. IL- 6， through p- STAT3 rather than p- STAT1， activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients： a cohort study［J］. BMC Gastroenterol， 2015， 15： 50.
［38］ Moran DM， Mattocks MA， Cahill PA， et al. Interleukin- 6 mediates G0/G1 growth arrest in hepatocellular carcinoma through a STAT 3- dependent pathway［J］. J Surg Res， 2008， 147： 23- 33.
［39］ Cho HJ， Kim SS， Ahn SJ， et al. Low serum interleukin- 6 levels as a predictive marker of recurrence in patients with hepatitis B virus related hepatocellular carcinoma who underwent curative treatment［J］. Cytokine， 2015， 73： 245- 252.
［40］ Beckebaum S， Zhang X， Chen X， et al. Increased levels of interleukin- 10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets［J］. Clin Cancer Res， 2004， 10： 7260- 7269.
［41］ Chau GY， Wu CW， Lui WY， et al. Serum interleukin- 10 but not interleukin- 6 is related to clinical outcome in patients with resectable hepatocellular carcinoma［J］. Ann Surg， 2000， 231： 552- 558.
［42］ Saxena R， Chawla YK， Verma I， et al. Association of interleukin- 10 with hepatitis B virus（HBV） mediated disease progression in Indian population［J］. Indian J Med Res， 2014， 139： 737- 745.
［43］ Hansler J， Wissniowski TT， Schuppan D， et al. Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radiofrequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases［J］. World J Gastroenterol， 12： 3716- 3721.
［44］ Erinjeri JP， Thomas CT， Samoilia A， et al. Image- guided thermal ablation of tumors increases the plasma level of interleukin- 6 and interleukin- 10［J］. J Vasc Interv Radiol， 2013， 24： 1105- 1112.

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备注/Memo

备注/Memo:
（收稿日期：２０１6-０5-０3）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2017-01-17