[1]许 军,贺克武,高 斌,等.叶酸偶联金纳米棒在兔VX 2肝癌的摄取状况研究[J].介入放射学杂志,2015,(04):328-332.
 U Jun,HE Ke wu,GAO Bin,et al.The intake of folate conjugated silica coated gold nanorods in rabbits with VX 2 liver cancer: an experimental study[J].journal interventional radiology,2015,(04):328-332.
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叶酸偶联金纳米棒在兔VX 2肝癌的摄取状况研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年04期
页码:
328-332
栏目:
实验研究
出版日期:
2015-04-25

文章信息/Info

Title:
The intake of folate conjugated silica coated gold nanorods in rabbits with VX 2 liver cancer: an experimental study
作者:
许 军 贺克武 高 斌 杨会军 沈 蕾 肖卫华
Author(s):
U Jun HE Ke wu GAO Bin YANG Hui jun SHEN Lei XIAO Wei hua.
Medical Imaging Center, the Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230061, China
关键词:
VX 2肝癌模型 叶酸偶联金纳米棒 叶酸受体 靶向性
文献标志码:
A
摘要:
目的 建立兔肝癌模型,观察实验动物对叶酸(FA)偶联二氧化硅包覆的金纳米棒(GNRs@SiO2 FA)的摄取状况,检测GNRs@SiO2 FA对肝癌细胞的靶向性。方法 CT引导下穿刺接种法建立兔VX 2肝癌模型27只,行CT、超声检查观察肿瘤生长情况。2周后将实验动物随机分成空白对照组(注入生理盐水)、门静脉注射GNRs@SiO2 FA组和瘤内注射GNRs@SiO2 FA组,术后24、48、72 h每组各处死实验兔3只,取其肿瘤组织和各主要脏器并作冷冻切片,应用激光共聚焦显微镜观察实验动物对GNRs@SiO2 FA的摄取情况。结果 成功构建兔VX 2肝癌模型,CT、超声检查显示肿瘤血供较丰富。共聚焦显微镜观察到实验动物摄入GNRs@SiO2 FA 24 h内即可特异性地与肿瘤细胞结合进入肿瘤细胞,并聚集在肿瘤细胞胞质内。结论 GNRs@SiO2 FA可在实验动物体内高度靶向性作用于肝癌细胞,在肿瘤靶向定位热疗和125I粒子介入治疗方面具有重要的应用前景。

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备注/Memo

备注/Memo:
(收稿日期:2014-10-23)
(本文编辑:边 佶)
更新日期/Last Update: 2015-04-27