[1]韩聚强,范公忍,任永强,等. 不同微创介入治疗原发性肝癌对机体T细胞免疫功能的影响[J].介入放射学杂志,2014,(03):218-221.
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 不同微创介入治疗原发性肝癌对机体T细胞免疫功能的影响 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年03期
页码:
218-221
栏目:
肿瘤介入
出版日期:
2014-03-25

文章信息/Info

Title:
 The influence of different micro?蛳 injury interventional treatments on the T lymphocyte immune function in patients with primary hepatocellular carcinoma
作者:
 韩聚强;  范公忍;  任永强;  郭汉斌;  李国安;  夏长虹;  王 帅;  龚丽娟;  曹建彪
Author(s):
 HAN Ju?蛳 qiang;  FAN Gong?蛳 ren;  REN Yong?蛳 qiang;  GUO Han?蛳 bin;  LI Guo?蛳 an;  XIA Chang?蛳 hong;  WANG Shuai;  GONG Li?蛳 juan;  CAO Jian?蛳 biao.
 Institute of Liver Disease， General Hospital of Beijing Military Region， Beijing 100700， China
关键词:
 ; 【关键词】 肝细胞癌;  肝动脉栓塞化疗术;  射频消融治疗术;  免疫功能
文献标志码:
A
摘要:
 【摘要】 目的 探讨微创介入治疗肝癌对机体T细胞免疫功能的影响。方法 肝动脉栓塞化疗（TACE）治疗肝癌31例，射频消融（RFA）治疗肝癌19例，根据肿瘤直径大小分为小肝癌组（直径 ≤ 5 cm）和大肝癌组（直径 > 5 cm）。分别于术前及术后1、7 d留置外周血，用流式细胞术检测CD3、CD4、CD8及 CD4/CD8比值的变化。结果 小肝癌组，TACE与RFA治疗术后1 d外周血T细胞亚群无明显变化，但术后7 d时，RFA治疗组外周血T细胞亚群 CD3、CD4、CD8及CD4/CD8比值较治疗前相比明显增高，而TACE组外周血T细胞亚群 CD4及CD4/CD8比值较治疗前明显下降。大肝癌组，无论TACE还是RFA治疗，术后1 d外周血T细胞亚群指标较治疗前明显下降（P < 0.05），而7 d后外周血T细胞亚群 CD3、CD4、CD8及CD4/CD8比值较治疗前显著增高，其中RFA组T细胞亚群较TACE组恢复更为显著。结论 不同微创治疗方式治疗肝癌后对机体T细胞免疫系统影响不同，与肿瘤大小密切相关。

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 （收稿日期：２０１3-０8-2０）
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