[1]王 伟,盛娜萍,江永焰,等. X线导引下针刺诱导兔椎间盘退行改变的研究[J].介入放射学杂志,2013,(12):1021-1026.
　WANG Wei,Sheng Na? ping,JIANG Yong? yan,et al. Needle puncturing?蛳 induced intervertebral disc degeneration： an experimental study in rabbits[J].journal interventional radiology,2013,(12):1021-1026.
点击复制

 X线导引下针刺诱导兔椎间盘退行改变的研究 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年12期
页码:
1021-1026
栏目:
实验研究
出版日期:
2013-12-25

文章信息/Info

Title:
 Needle puncturing?蛳 induced intervertebral disc degeneration： an experimental study in rabbits
作者:
 王 伟;  盛娜萍;  江永焰;  叶 刚;  林波淼;  全显跃;  俞志坚
Author(s):
 WANG Wei;  Sheng Na?蛳 ping;  JIANG Yong?蛳 yan;  YE Gang;  LIN Bo?蛳 miao;  QUAN Xian?蛳 yue;  YU Zhi?蛳 jian.
 Department of Radiology， Zhujiang Hospital， Southern Medical University， Guangzhou， Guangdong Province 510282， China
关键词:
 ; 【关键词】 椎间盘退行性改变;  磁共振;  穿刺;  动物实验
文献标志码:
A
摘要:
 【摘要】 目的 采用X线导引下针刺诱导建立兔椎间盘退行性变（退变）模型，并对椎间盘进行T2 Mapping检测，为深入研究椎间盘退变的磁共振（MR）定量检测奠定基础。方法 选择新西兰大白兔5只，在X线导引下采用穿刺髓核和穿刺软骨终板两种手术方式，分别在穿刺前、穿刺后30 min、4和8周进行常规T2WI、T2 Mapping成像和CT三维重建等影像学检查，8周时对诸椎间盘进行病理学分析。结果 造模后30 min，各椎间盘MR信号未见明显异常；4周穿刺髓核组T2WI信号明显降低，高信号区范围缩小；T2 Mapping显示高值范围明显缩小；8周髓核变化与4周类似，未见明确退变进展；正常对照组和穿刺软骨终板组的椎间盘信号和量值改变不明显。病理学检查发现穿刺髓核组的髓核组织发生非常明显的退变，而穿刺软骨终板组发生轻度退变。结论 采用X线导引下针刺椎间盘髓核的方式成功建立兔椎间盘退变模型，此模型具有操作简单、经济、并发症低、影响因素少等优势，并且证明了T2 Mapping技术可用于兔椎间盘退变的检测，为深入研究MR定量技术对椎间盘退变的价值奠定了基础。 

参考文献/References:

 ［1］ 宋红梅， 吴春根， 程永德． 椎间盘源性疼痛的机制及其治疗进展［J］． 介入放射学杂志， 2012， 21： 790 ?蛳 794．
［2］ Zhou H， Hou S， Shang W， et al. A new in vivo animal model to create intervertebral disc degeneration characterized by MRI， radiography， CT/discogram， biochemistry， and histology［J］. Spine （Phila Pa 1976）， 2007， 32： 864 ?蛳 872.
［3］ Hsieh AH， Hwang D， Ryan DA， et al. Degenerative anular changes induced by puncture are associated with insufficiency of disc biomechanical function［J］. Spine （Phila Pa 1976）， 2009， 34： 998 ?蛳 1005.
［4］ 王 鹏， 徐海孺， 骆国钢， 等． 经皮穿刺纤维环法诱导兔腰椎间盘退变模型［J］． 浙江中西医结合杂志， 2009， 19： 668 ?蛳 670．
［5］ Elliott DM， Yerramalli CS， Beckstein JC， et al. The effect of relative needle diameter in puncture and sham injection animal models of degeneration［J］. Spine （Phila Pa 1976）， 2008， 33： 588 ?蛳 596.
［6］ Korecki CL， Costi JJ， Iatridis JC. Needle puncture injury affects intervertebral disc mechanics and biology in an organ culture model［J］. Spine （Phila Pa 1976）， 2008， 33： 235 ?蛳 241.
［7］ Keorochana G， Johnson JS， Taghavi CE， et al. The effect of needle size inducing degeneration in the rat caudal disc： evaluation using radiograph， magnetic resonance imaging， histology， and immunohistochemistry［J］. Spine J， 2010， 10： 1014 ?蛳 1023.
［8］ Michalek AJ， Funabashi KL， Iatridis JC. Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently［J］. Eur Spine J， 2010， 19： 2110 ?蛳 2116.
［9］ Kim KS， Yoon ST， Li J， et al. Disc degeneration in the rabbit： a biochemical and radiological comparison between four disc injury models［J］. Spine （Phila Pa 1976）， 2005， 30： 33 ?蛳 37.
［10］ Masuda K， Aota Y， Muehleman C， et al. A novel rabbit model of mild， reproducible disc degeneration by an anulus needle puncture： correlation between the degree of disc injury and radiological and histological appearances of disc degeneration［J］. Spine （Phila Pa 1976）， 2005， 30： 5 ?蛳 14.
［11］ Sobajima S， Kompel JF， Kim JS， et al. A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI， X?蛳 ray， and histology［J］. Spine （Phila Pa 1976）， 2005， 30： 15 ?蛳 24.
［12］ Kong MH， Do DH， Miyazaki M， et al. Rabbit model for in vivo study of intervertebral disc degeneration and regeneration［J］. J Korean Neurosurg Soc， 2008， 44： 327 ?蛳 333.

相似文献/References:

[1].Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].介入放射学杂志,2007,(10):718.
　ZHANG He,LI Ming-hua,WANG Chun,et al.Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury ：case report and literature review[J].journal interventional radiology,2007,(12):718.
[2]李统怀,郑红枫. 子宫动脉栓塞治疗子宫瘢痕妊娠１１例[J].介入放射学杂志,2011,(11):898.
　LI Tong-huai,ZHENG Hong-feng..Clinical application of uterine artery embolization in treating uterine scar pregnancy[J].journal interventional radiology,2011,(12):898.
[3]吕维富,张爱武,周春泽,等. 子宫动脉的三维DSA表现及其最佳显示体位探讨[J].介入放射学杂志,2011,(11):853.
　LV Wei-fu,ZHANG Ai-wu,ZHOU Chun-ze,et al.3D-DSA findings of uterine artery and its optimal projection position[J].journal interventional radiology,2011,(12):853.
[4]张 靖,周少毅,陈昆山,等.经导管动脉硬化栓塞联合注射硬化治疗婴儿颌面部巨大高流量血管瘤[J].介入放射学杂志,2011,(11):848.
　ZHANG Jing,ZHOU Shao-yi,CHEN Kun-shan,et al.Transcatheter arterial sclerosing embolization with injection sclerotherapy for the treatment of huge and high-flow maxillofacial hemangiomas in infants[J].journal interventional radiology,2011,(12):848.
[5]谢小西,吕银祥,章宏欣,等. 肝动脉化疗栓塞、射频消融联合１２５Ⅰ粒子植入 治疗原发性肝癌的临床应用[J].介入放射学杂志,2011,(11):863.
　XIE Xiao-xi,LV Yin-xiang,ZHANG Hong-xin,et al.The clinical application of TACE together with RFA and 125Ⅰ seed implantation in treating hepatocellular carcinoma[J].journal interventional radiology,2011,(12):863.
[6]王铭义,王 峰. 脑灌注成像在颈动脉狭窄介入治疗中的应用[J].介入放射学杂志,2011,(11):915.
　WANG Ming-yi,WANG Feng..Application of brain perfusion imaging in interventional treatment of carotid artery stenosis[J].journal interventional radiology,2011,(12):915.
[7]杜 猛,张锦生. 介入治疗急性深静脉血栓的临床观察[J].介入放射学杂志,2011,(11):858.
　DU Meng,ZHANG Jing-sheng..Interventional therapy for acute deep venous thrombosis: a clinical observation[J].journal interventional radiology,2011,(12):858.
[8]孟庆娜,李国庆,白晓冬. 急性心肌梗死介入治疗术中恶心呕吐的护理[J].介入放射学杂志,2011,(11):913.
　MENG Qing-na,LI Guo-qing,BAI Xiao-dong..The nursing care of nausea and vomiting occurred in interventional treatment for acute myocardial infarction[J].journal interventional radiology,2011,(12):913.
[9]王海亭,蒋忠仆,周 毅,等. 透视引导下鱼肝油酸钠泡沫硬化剂治疗下肢静脉曲张３０例[J].介入放射学杂志,2011,(11):905.
　WANG Hai-ting,JIANG Zhong-pu,ZHOU Yi,et al.Fluoroscopically-guided foam sclerotherapy with sodium morrhuate for the treatment of lower extremity varices[J].journal interventional radiology,2011,(12):905.
[10]杜 鲲,管 生,胡小波,等. 原发性肝癌ＴＡＣＥ术后完全缓解病灶磁共振 ＡＤＣ值可重复性及一致性研究[J].介入放射学杂志,2011,(11):867.
　DU Kun,GUAN Sheng,HU Xiao-bo,et al.Magnetic resonance apparent diffusion coefficient values of the completely remitted lesions of primary hepatocellular carcinoma after TACE: a study of their repeatability and consistency[J].journal interventional radiology,2011,(12):867.

备注/Memo

备注/Memo:
 （收稿日期：２０１3-０5-26）
更新日期/Last Update: