[1]陈万海,朱晓黎.射频消融联合无水乙醇注射在兔肝脏中的实验研究[J].介入放射学杂志,2012,(12):1015-1019.
　CHEN Wan? hai,ZHU Xiao? li.. Combined use of radiofrequency ablation and percutaneous ethanol injection for liver tissue： an in vivo experimental study in rabbits[J].journal interventional radiology,2012,(12):1015-1019.
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射频消融联合无水乙醇注射在兔肝脏中的实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年12期
页码:
1015-1019
栏目:
实验研究
出版日期:
2012-12-25

文章信息/Info

Title:
 Combined use of radiofrequency ablation and percutaneous ethanol injection for liver tissue： an in vivo experimental study in rabbits
作者:
 陈万海;  朱晓黎
Author(s):
 CHEN Wan?蛳 hai;  ZHU Xiao?蛳 li.
 Department of Interventional Radiology， Affiliated First People’s Hospital of Suzhou University， Suzhou， Jiangsu Province 215006， China
关键词:
 ; 【关键词】 肝脏;  射频消融;  无水乙醇;  兔
文献标志码:
A
摘要:
 【摘要】 目的 研究不同方式的射频消融（RFA）与无水乙醇注射（PEI）联合应用对正常兔肝脏的消融效果，并评价其安全性和实用性。方法 采用32只活体新西兰大白兔正常肝脏进行研究，分为4组，各组分别采用RFA?蛳 PEI（A组）、PEI?蛳 RFA（B组）、RFA（C组）和PEI（D组）处理，并于术前，术后1、3、7 d抽血检查丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、血清肌酐（Cr）水平的变化情况。术后各组行肝脏增强CT扫描，计算各组消融灶体积。结果 术前各组血清ALT、AST、Cr水平差异无统计学意义（P ＞ 0.05）；术后1 d各组血清ALT、AST与术前差异有统计学意义（P ＜ 0.05）；术后3 d各组血清ALT、AST水平开始下降，术后7 d各组ALT、AST与术前差异无统计学意义（P ＞ 0.05），术后1、3、7 d各组血清Cr与术前比较均差异无统计学意义（P ＞ 0.05）。A、B、C和D组的消融体积分别为（3.10 ± 1.10）mm3、（5.99 ± 2.23）mm3、（0.77 ± 0.15）mm3和（0.15 ± 0.07）mm3，B组显著大于A、C和D组（P ＜ 0.05）。结论 PEI后RFA对于兔肝、肾功能影响小、并发症少，PEI?蛳 RFA治疗安全、有效；PEI?蛳 RFA组产生的消融体积明显大于RFA后PEI组、RFA组、PEI组的消融体积。

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备注/Memo

备注/Memo:
 （收稿日期：２０１2-０8-０1）
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