[1]潘静薇,陆志刚,张佳胤,等. 冠状动脉介入治疗后迟发型对比剂肾病[J].介入放射学杂志,2013,(01):15-019.
　PAN Jing? wei,LU Zhi? gang,ZHANG Jia? yin,et al. Delayed contrast?蛳 induced nephropathy occurring after percutaneous coronary intervention[J].journal interventional radiology,2013,(01):15-019.
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年01期
页码:
15-019
栏目:
心脏介入
出版日期:
2013-01-25

文章信息/Info

Title:
 Delayed contrast?蛳 induced nephropathy occurring after percutaneous coronary intervention
作者:
 潘静薇;  陆志刚;  张佳胤;  宣昶有;  祁 晟;  汪年松;  魏 盟
Author(s):
 PAN Jing?蛳 wei;  LU Zhi?蛳 gang;  ZHANG Jia?蛳 yin;  XUAN Chang?蛳 you;  QI Sheng;  WANG Nian?蛳 song;  WEI Meng.
 Department of Cardiology， Shanghai Sixth People’s Hospital， Shanghai Jiaotong University， Shanghai 200233， China
关键词:
 ; 【关键词】 冠心病;  介入治疗;  肾功能不全;  碘克沙醇
文献标志码:
A
摘要:
 【摘要】 目的 观察等渗非离子型对比剂碘克沙醇对接受冠状动脉介入治疗（PCI）患者近期及远期肾功能的影响，探讨迟发型（> 1个月）对比剂肾病（delayed contrast induced nephropatholgy， DCIN）的诱因及危害。方法 观察2007年6月至2011年6月242例采用碘克沙醇行PCI治疗患者，根据PCI前24 h、PCI后2 ～ 3 d、1个月和3个月的血清肌酐水平，将患者分为对比剂肾病（CIN）组、DCIN组和肾功能无恶化组，评价多种危险因素与DCIN的相关性。结果 与PCI术后肾功能无恶化组（5.02 ± 1.64）相比，DCIN组和CIN组Mehran 危险积分显著升高（分别为6.72 ± 2.48 和6.97 ± 2.51），组间差异有统计学意义（P <0.001）；DCIN组和CIN组中，糖尿病、慢性肾功能不全、心功能不全等疾病伴发率显著增高（P < 0.05）；临床心血管事件率和全因死亡率显著增高（P < 0.05），但上述因素在CIN组和DCIN组间差异无统计学意义（P > 0.05）。结论 在PCI术前应用Mehran危险积分可以充分评估CIN风险。即使具有很好的肾脏耐受性，等渗对比剂同样需要注意术中用量。PCI术后长期监测患者肾功能与治疗前充分评估CIN风险同样重要。

参考文献/References:

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 （收稿日期：２０１2-０7-25）
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