[1]胡永进,杜学明,许建辉,等.125Ⅰ粒子植入联合长春瑞滨加顺铂方案治疗纵隔肿瘤压迫性中心气道狭窄的疗效观察[J].介入放射学杂志,2012,(03):228-231.
 ,,et al.CTguided 125Ⅰ seeds implantation combined with NP chemotherapy for the treatment of intractable central airway stenosis caused by NSCLC [J].journal interventional radiology,2012,(03):228-231.
点击复制

125Ⅰ粒子植入联合长春瑞滨加顺铂方案治疗纵隔肿瘤压迫性中心气道狭窄的疗效观察 ()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年03期
页码:
228-231
栏目:
非血管介入
出版日期:
2012-03-28

文章信息/Info

Title:
CTguided 125Ⅰ seeds implantation combined with NP chemotherapy for the treatment of intractable central airway stenosis caused by NSCLC  
作者:
 胡永进 杜学明 许建辉 吴春娃
Author(s):
 HU Yongjin DU Xueming XU Jianhui WU Chunwa.  
 Xinji Municipal Hospital of Traditional Chinese Medicine, Xinji City, Hebei Province 052360, China
关键词:
 【关键词】   纵隔肿瘤 气道狭窄 125Ⅰ粒子 术中植入 队列研究
文献标志码:
A
摘要:
 【摘要】 目的   探讨125Ⅰ粒子植入联合长春瑞滨联合顺铂(NP)化疗治疗纵隔型非小细胞肺癌(NSCLC)压迫所致中心性气道狭窄的临床价值。方法 天津北辰医院肿瘤介入科前瞻性队列研究,入组时间为2004年1月至2010年3月。80例患者随机分为治疗组(42例)依据治疗计划,采用CT引导下单针椎形分布、处方剂量(PD) = 80 ~ 100 GY植入125Ⅰ粒子,源强0.8 mCi,术后CT扫描,并进行治疗计划系统(TPS)评估,验证治疗计划。3 d后给予长春瑞滨(NVB)联合顺铂(DDP)静脉化疗,对照组(38例)单纯应用NVB联合DDP静脉化疗,药物剂量与治疗组参考标准相同,化疗2个周期后观察两组患者气道最狭窄处横截面积及评估呼吸困难指数的变化情况。结果 术后2个月随访,随访率100%。治疗组患者治疗前气道狭窄率为47.82% ± 17.55%,125Ⅰ粒子植入术 + 2个周期化疗后气道狭窄率为15.76% ± 4.65%,患者气道通畅,呼吸困难改善明显,术后气道横截面积改变与呼吸困难指数改善与术前存在明 显差异(P < 0.05)。对照组患者治疗前气道狭窄率为46.24% ± 16.83%, 2个周期化疗后气道狭窄率为40.15% ± 5.08%,气道横截面积改变与呼吸困难指数改善无明显差异(P > 0.05)。结论 125Ⅰ粒子植入联合化疗治疗纵隔型NSCLC压迫所致中心性气道狭窄是一种迅速、有效的治疗方法。

参考文献/References:

[1]   Jin FG, Fu EQ, Xie YH, et al. The application of combined interventional procedures for the management of intractable central airway stenosis[J]. Zhonghua Jie He He Hu Xi Za Zhi, 2010, 33: 21  24.
[2]   Zhang FJ, Li CX, Wu PH, et al. CT guided radioactive 125Ⅰ seed implantation in treating localized advanced pulmonary carcinoma[J]. Zhonghua Yi Xue Za Zhi(Taipei), 2007, 87: 3272  3275.
[3]   黄振国, 张雪哲, 王   武, 等. CT导引下I125粒子植入在治疗恶性肿瘤的应用[J]. 中华放射学杂志, 2004, 3: 921  925.
[4]   Parashar B, Patel P, Monni S, et al. Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung Cancer[J]. Cancer, 2010, 7: 5047  5053.
[5]   韦国帧, 殷小伟. CT引导下组织间植入125Ⅰ粒子治疗肺癌的临床研究[J]. 中国微创外科杂志, 2008, 8: 243  245.
[6]   胡   宁, 柯明耀. CT引导下植入125Ⅰ粒子治疗肺部肿瘤[J].中国医学影像学杂志, 2008, 16: 459  461.
[7]   李   卫, 但   刚, 姜建清, 等. 多发肺转移节结~125Ⅰ粒子植入技巧及临床应用[J]. 中国肺癌杂志, 2010, 13: 230  233.
[8]   Liu L, Wang XW, Li L, et al. A randomized comparative trial of three combined regimens containing cisplatin for treatment of advanced nonsmall cell lung Cancer[J]. Ai Zheng, 2006, 25: 990  994.
[9]   张福君, 吴沛宏, 顾仰葵, 等. CT导引下组织间植入125Ⅰ治疗肺转移瘤[J]. 中华放射学杂志, 2004, 38: 906  909.
[10]   张福君, 焦德超, 李传行, 等. CT导向下125Ⅰ粒子植入治疗复发/转移性盆腔恶性肿瘤的近中期疗效评价[J]. 中华医学杂志, 2008, 88: 3063  3067.

相似文献/References:

[1].Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury :case report and literature review[J].介入放射学杂志,2007,(10):718.
 ZHANG He,LI Ming-hua,WANG Chun,et al.Spontaneous regression of a giant basilar artery aneurysm in a young adult after surgical injury :case report and literature review[J].journal interventional radiology,2007,(03):718.
[2]李统怀,郑红枫. 子宫动脉栓塞治疗子宫瘢痕妊娠11例[J].介入放射学杂志,2011,(11):898.
 LI Tong-huai,ZHENG Hong-feng..Clinical application of uterine artery embolization in treating uterine scar pregnancy[J].journal interventional radiology,2011,(03):898.
[3]吕维富,张爱武,周春泽,等. 子宫动脉的三维DSA表现及其最佳显示体位探讨[J].介入放射学杂志,2011,(11):853.
 LV Wei-fu,ZHANG Ai-wu,ZHOU Chun-ze,et al.3D-DSA findings of uterine artery and its optimal projection position[J].journal interventional radiology,2011,(03):853.
[4]张 靖,周少毅,陈昆山,等.经导管动脉硬化栓塞联合注射硬化治疗婴儿颌面部巨大高流量血管瘤[J].介入放射学杂志,2011,(11):848.
 ZHANG Jing,ZHOU Shao-yi,CHEN Kun-shan,et al.Transcatheter arterial sclerosing embolization with injection sclerotherapy for the treatment of huge and high-flow maxillofacial hemangiomas in infants[J].journal interventional radiology,2011,(03):848.
[5]谢小西,吕银祥,章宏欣,等. 肝动脉化疗栓塞、射频消融联合125Ⅰ粒子植入 治疗原发性肝癌的临床应用[J].介入放射学杂志,2011,(11):863.
 XIE Xiao-xi,LV Yin-xiang,ZHANG Hong-xin,et al.The clinical application of TACE together with RFA and 125Ⅰ seed implantation in treating hepatocellular carcinoma[J].journal interventional radiology,2011,(03):863.
[6]王铭义,王 峰. 脑灌注成像在颈动脉狭窄介入治疗中的应用[J].介入放射学杂志,2011,(11):915.
 WANG Ming-yi,WANG Feng..Application of brain perfusion imaging in interventional treatment of carotid artery stenosis[J].journal interventional radiology,2011,(03):915.
[7]杜 猛,张锦生. 介入治疗急性深静脉血栓的临床观察[J].介入放射学杂志,2011,(11):858.
 DU Meng,ZHANG Jing-sheng..Interventional therapy for acute deep venous thrombosis: a clinical observation[J].journal interventional radiology,2011,(03):858.
[8]孟庆娜,李国庆,白晓冬. 急性心肌梗死介入治疗术中恶心呕吐的护理[J].介入放射学杂志,2011,(11):913.
 MENG Qing-na,LI Guo-qing,BAI Xiao-dong..The nursing care of nausea and vomiting occurred in interventional treatment for acute myocardial infarction[J].journal interventional radiology,2011,(03):913.
[9]王海亭,蒋忠仆,周 毅,等. 透视引导下鱼肝油酸钠泡沫硬化剂治疗下肢静脉曲张30例[J].介入放射学杂志,2011,(11):905.
 WANG Hai-ting,JIANG Zhong-pu,ZHOU Yi,et al.Fluoroscopically-guided foam sclerotherapy with sodium morrhuate for the treatment of lower extremity varices[J].journal interventional radiology,2011,(03):905.
[10]杜 鲲,管 生,胡小波,等. 原发性肝癌TACE术后完全缓解病灶磁共振 ADC值可重复性及一致性研究[J].介入放射学杂志,2011,(11):867.
 DU Kun,GUAN Sheng,HU Xiao-bo,et al.Magnetic resonance apparent diffusion coefficient values of the completely remitted lesions of primary hepatocellular carcinoma after TACE: a study of their repeatability and consistency[J].journal interventional radiology,2011,(03):867.

备注/Memo

备注/Memo:
 (收稿日期:20110730)
更新日期/Last Update: