[1]谭中宝,刘璐,郭金和,等.32P粒子植入对正常肝组织损伤及体内代谢的实验研究[J].介入放射学杂志,2010,(04):309.
TAN Zhongbao,LIU Lu,GUO Jinhe,et al.The metabolism of 32P-CP-PLLA seed implanted in the liver and its damage to the normal liver tissue:a study in the experimental dogs[J].journal interventional radiology,2010,(04):309.
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P粒子植入对正常肝组织损伤及体内代谢的实验研究()
《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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- 期数:
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2010年04期
- 页码:
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309
- 栏目:
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实验研究
- 出版日期:
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2010-04-15
文章信息/Info
- Title:
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The metabolism of
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P-CP-PLLA seed implanted in the liver and its damage to the normal liver tissue:a study in the experimental dogs
- 作者:
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谭中宝; 刘璐; 郭金和; 等
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21009南京东南大学附属中大医院介入科(谭中宝、郭金和、朱光宇、滕皋军);东南大学临床医学院核医学技术研究所(刘璐、聂琦、高海林)
- Author(s):
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TAN Zhong-bao; LIU Lu; GUO Jin-he; ZHU Guang-yu; WANG Fu-an; NIE Qi ; GAO Hai-lin; TENG Gao-jun
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Affiliated Zhongda Hospital,Southeast University,Nanjing210009,China
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- 关键词:
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P-CP-PLLA粒子; 内放射治疗; 间质; 靶向定位; 安全性
- 分类号:
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R730.55
- 文献标志码:
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B
- 摘要:
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目的观察
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P-磷酸铬-聚L-乳酸(
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P-CP-PLLA)粒子对正常犬肝组织损伤效应,及其体内代谢和缓释效应。方法Beagle犬12只,随机分为4个剂量组,A组185MBq、B组370MBq、C组740MBq,D组为空白对照假手术组。采用开腹将
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P-CP-PLLA粒子植入犬肝脏内,3个月后处死。术前及处死前均行CT扫描,术前及术后1、2、4、8、12周进行血象及血清生化检查,B、C两组各选1只于代谢笼内饲养,术后1个月内每24h测量粪便及尿液放射性计数率值(cpm),术后1、2、4、8、12周每组选1只犬行肝穿刺及SPECT韧致辐射显像,处死时行病理学检查。结果所有实验犬血象及血生化各项指标未见明显异常;术后30d的排泄物放射性检查表明粒子在体内缓慢释放;尿、粪排出的放射性计数累积百分率分别为6.34%和11.64%;SPECT显像示无粒子移位现象;3个月后解剖发现粒子体积变小、质地松脆,CT、大体标本和病理学检查结果均发现随着剂量增大,肝脏内粒子植入部位毁损灶增大。32
P-CP-PLLA粒子造成的局部肝损伤呈一球形灶:纤维化组织包绕坏死灶,外周可见一圈水肿带。结论
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P-CP-PLLA粒子植入犬肝脏后对肝组织内的损伤是局限的,不会造成全身的不良反应,在体内无脏器迁移,并呈现缓慢释放,显示出良好体内稳定性、靶向定位性和安全性。
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P-磷酸铬-聚L-乳酸缓释粒子体内外释出率及体内生物分布的初步研究[J].中华核医学杂志,2009,29:189-193.
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P-磷酸铬间质给药对犬累积损伤效应的研究[J].中华放射医学与防护杂志,2010,30:7-14.
备注/Memo
- 备注/Memo:
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收稿日期:2009-10-14
基金项目:国家高技术研究发展计划(863计划)(2007AA02Z471)
更新日期/Last Update:
2010-04-15