[1]杜海军.重组人血管内皮抑素联合肝动脉灌注化疗栓塞治疗中晚期肝癌的临床应用[J].介入放射学杂志,2009,(04):302-305.
　DU Haijun.Intrahepatic arterial infusion of endostatin combined with transcatheter arterial chemoembolization for the treatment of advanced hepatocellular carcinoma[J].journal interventional radiology,2009,(04):302-305.
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重组人血管内皮抑素联合肝动脉灌注化疗栓塞治疗中晚期肝癌的临床应用()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年04期
页码:
302-305
栏目:
临床研究
出版日期:
2009-04-15

文章信息/Info

Title:
Intrahepatic arterial infusion of endostatin combined with transcatheter arterial chemoembolization for the treatment of advanced hepatocellular carcinoma
作者:
杜海军
322100  浙江 东阳市人民医院介入科
Author(s):
DU Hai－jun．
Department of Interventional Radiology，Dongyang Municipal People’s Hospital，Zhejiang３２２１００，China
关键词:
肝动脉灌注; 栓塞; 肝癌; 重组人内皮抑素
分类号:
R７３５.７
文献标志码:
B
摘要:
目的研究重组人血管内皮抑制素（内皮抑素）联合肝动脉TACE治疗中晚期肝癌的临床疗效及安全性。方法选取４０例中晚期肝癌患者，随机分成两组。治疗组常规TACE加重组人内皮抑素－碘化油乳剂栓塞；对照组单纯给予常规TACE。所有患者术后１年内不定期复查CT或MRI ，以及DSA检查。观察肿瘤复发或转移情况以及有无肿瘤新生血管形成。比较瘤体缩小情况，AFP变化，６个月、１年的生存率以及生活质量。同时比较两组术后不良反应。结果治疗组１年生存率、AFP下降程度显著高于对照组，治疗组与对照组１年生存率分别为７５％（１５／２０）和６０％（１２／２０）；AFP下降值平均差为３００μg ／ml ；肿瘤新生血管、转移抑制明显。结论内皮抑素联合TACE治疗中晚期肝癌，患者１年生存率显著提高，AFP下降明显，肿瘤新生血管、转移抑制明显，且安全，具有较好的临床应用前景，值得临床进一步研究。

参考文献/References:

［１］Folkman J．Role of angiogenesis in tumor growth and metastasis［J］．Semin Oncol，２００２，２９（６Suppl １６）：１５－１８．
［２］李树婷，孙燕．肿瘤血管抑制剂的研究历史、现状和发展前景［J］．癌症进展，２００３，１：８０－８７．
［３］Huang X，Wong MK，Zhao Q，et al．Soluble recombinant endostatinpurified from Escherichia

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备注/Memo

备注/Memo:
收稿日期：２００８－１２－０９
更新日期/Last Update: 2009-04-15