[1]白卫星,李天晓,翟水亭,等.布－加综合征隔膜组织病理学与相关因素研究[J].介入放射学杂志,2008,(07):463.
　BAI Weixing,LI Tianxiao,ZHAI Shuiting,et al.Study of the septal membranous organization pathology and the correlative factors of the Budd－Chiari syndrome[J].journal interventional radiology,2008,(07):463.
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布－加综合征隔膜组织病理学与相关因素研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2008年07期
页码:
463
栏目:
血管介入
出版日期:
2008-07-15

文章信息/Info

Title:
Study of the septal membranous organization pathology and the correlative factors of the Budd－Chiari syndrome
作者:
白卫星; 李天晓; 翟水亭; 等
４５０００３郑州河南省人民医院介入科
Author(s):
BAI Wei－xing; LI Tian－xiao; ZHAI Shui－ting; MA Xiu－xian; CAO Hui－cun; WANG Zi－liang．
Department of Interventional Radiology，Henan People's Provincial Hospital，Zhengzhou４５０００３，China
关键词:
布－加综合征; 病因学; 病理学; 免疫; 细胞因子
分类号:
R５４３.６
文献标志码:
A
摘要:
目的研究布－加综合征（BCS）隔膜组织与正常下腔静脉中生长因子受体的表达，观察分析BCS隔膜组织的病理改变与患者性别和肝功能储备间相关性，进一步了解膜性BCS的发病机制。方法隔膜组织标本来自我院１９８８－２０００年BCS患者外科切除组织蜡块，共３４例，设为实验组；另外切取１６例肾移植供体的下腔静脉组织，设为对照组。免疫组化检测TGFβR、PDGFR、FGFR和ET－１在隔膜组织内的表达。比较上述指标在BCS隔膜组织与正常下腔静脉表达的差异，并研究病理表现与患者性别及肝功能分级的关系。结果正常血管与BCS隔膜组织中均有TGFβR、PDGFR、FGFR及ET－１阳性细胞，４种指标在正常血管与BCS隔膜组织表达率分别为０．２１±０．０７和０．３８±０．１４（TGFR），０．３０±０．０８和０．５２±０．０７（PDGFR），０．２４±０．０６和０．５０±０．１１（FGFR），０．２４±０．０８和０．５４±０．１２（ET－１）；隔膜组织中上述指标的表达明显高于正常血管（P＜０．０５）。隔膜组织中的表达率与患者性别之间并无明显关系（P＞０．０５）；不同级别肝功能患者的ET－１表达有明显差异（P＜０．０５），肝功储备良好患者的ET－１表达率高于肝功能差。结论①炎症反应在一定程度上参与了BCS隔膜组织的形成。②BCS隔膜组织与正常血管对比，TGFβR、PDGFR、FGFR及ET－１表达存在差异。③上述生物因子的表达受多种因素影响，与患者性别无相关性，而与患者肝功能储备相关。

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　WANG Yi,ZHANG Hui,GUO Chenghao,et al.Pathologic and etiologic studies of membrane obstruction of the inferior vena cava in Budd－Chiari syndrome[J].journal interventional radiology,2008,(07):500.
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备注/Memo

备注/Memo:
收稿日期：２００７－０８－２８
更新日期/Last Update: 2008-07-15