[1]范勇,吴琦,梁春宝,等.单向活瓣支架介入治疗重度肺气肿的临床研究[J].介入放射学杂志,2008,(03):186.
FAN Yong,WU Qi,LIANG Chunbao,et al.An preliminary clinical study of transbronchoscopic interventional treatment for severe emphysema with local made one-way valvular stents[J].journal interventional radiology,2008,(03):186.
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单向活瓣支架介入治疗重度肺气肿的临床研究()
《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]
- 卷:
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- 期数:
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2008年03期
- 页码:
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186
- 栏目:
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非血管介入
- 出版日期:
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2008-03-15
文章信息/Info
- Title:
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An preliminary clinical study of transbronchoscopic interventional treatment for severe emphysema with local made one-way valvular stents
- 作者:
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范勇; 吴琦; 梁春宝; 等
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300350天津市海河医院放射科(范勇、吴琦、梁春宝、吴先杰、田静、杜钟珍、李萍、武俊平、史丽霞、赵崇法、李玉萍、于蕾);天津医科大学总医院(贺能树)
- Author(s):
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FAN Yong; WU Qi ; LIANG Chun-bao; WU Xian-jie; TIAN Jing; DU Zhong-zhen; LI Ping; WU Jun-ping; SHI Li-xia; ZHAO Chong-fa; LI Yu-ping; YU Lei; HE Neng-shu
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Tianjin Haihe Hospital,Tianjin300350,China
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- 关键词:
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肺气肿; 单向活瓣支架; 介入放射学; 支气管镜
- 分类号:
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R563.3
- 文献标志码:
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A
- 摘要:
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目的应用国产单向活瓣支架进行可弯曲支气管镜介入肺减容术(BILVR)临床研究,初步探索其安全性和疗效。方法2006年5月至2007年8月对7例重度肺气肿患者经胸部CT扫描确定靶位,在全身麻醉下行可弯曲支气管镜及X线引导支架置入。观察患者的临床症状、肺功能、血气分析、超声、6min步行距离(6MWD)及影像学表现。结果7例患者在单侧上叶支气管段或亚段放置4~6枚支架,手术时间为(136±72.3)min。术后2h可自行活动,呼吸困难明显减轻。术后影像学检查显示支架远端支气管聚拢,但未见肺不张。术后2周6MWD、Brog呼吸困难评分和肺动脉压差异有统计学意义(P﹤0.05)。肺功能、血气分析及靶区肺体积无明显变化。1例患者在术后2d出现非靶区下叶肺炎、1例患者出现慢性阻塞性肺疾病急性发作,均治疗后缓解。其余患者均未出现严重并发症。结论BILVR可能会改善极重度肺气肿患者呼吸困难的症状和生活质量,较为安全。
参考文献/References:
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[2]Toma TP,Hopkinson NS,Hillier J,et al.Bronchoscopic volume reduction with valve implants in patients with severe emphysema [J].Lancet,2003,361:931-933.
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[10]范勇,吴琦,梁春宝,等.国产支架支气管肺减容术在绵羊肺气肿模型中的初步应用[J].中国内镜杂志,2007,13:1049-1051.
[11]范勇,吴琦,梁春宝,等.国产支架经纤维支气管镜介入肺减容术初步应用[J].天津医药,2006,34:887-888.
[12]Hopkinson NS,Toma TP,Hansell DM,et al.Effect of broncho-scopic lung volume reduction on dynamic hyperinflation and exercise in emphysema [J].Am J Respir Crit Care Med,2005,171:453-460.
[13]Venuta F,de Giacomo T,Rendina EA,et al.Bronchoscopic lung-volume reduction with one-way valves in patients with heterogeneous emphysema [J].Ann Thorac Surg,2005,79:411-416.
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备注/Memo
- 备注/Memo:
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收稿日期:2006-12-28
更新日期/Last Update:
2008-03-15