[1]杨 凯,朱悦琦,苑天文,等.硅膜-镁合金可降解支架置入兔食管可行性及组织反应——体外和体内初步研究 [J].介入放射学杂志,2017,(09):816-822.
 YANG Kai,ZHU Yueqi,YUAN Tianwen,et al.Insertion of biodegradable silicon- covered magnesium alloy stent in esophagus: a preliminary in vitro and in vivo study of feasibility and tissue reaction in experimental rabbits[J].journal interventional radiology,2017,(09):816-822.
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硅膜-镁合金可降解支架置入兔食管可行性及组织反应——体外和体内初步研究 
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年09期
页码:
816-822
栏目:
实验研究
出版日期:
2017-09-25

文章信息/Info

Title:
Insertion of biodegradable silicon- covered magnesium alloy stent in esophagus: a preliminary in vitro and in vivo study of feasibility and tissue reaction in experimental rabbits
作者:
杨 凯 朱悦琦 苑天文 周 耕 崔文国 程英升
Author(s):
YANG Kai ZHU Yueqi YUAN Tianwen ZHOU Geng CUI Wenguo CHENG Yingsheng
Department of Medical Imaging, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
关键词:
【关键词】 可降解支架 镁合金 食管 组织反应 体内外实验
文献标志码:
A
摘要:
【摘要】 目的 体外研究硅膜-镁合金可降解支架的机械特性和降解行为,体内研究其置入兔食管的可行性及组织反应。方法 体外测试硅膜-镁合金可降解支架的机械压缩恢复性能和降解行为。30只健康荷兰兔随机分为硅膜-镁合金支架组(n=15,透视导引下将支架置入兔食管下1/3段)和对照组(n=15,未作任何干预),支架置入后1、2、4周两组兔分别接受食管造影,同时于各时间点分别处死5只兔,取材作组织学检查。结果 体外测试显示硅膜-镁合金可降解支架表现出良好的柔韧性和弹性,在pH4.0、pH7.4磷酸缓冲液中降解均慢于镁合金裸支架;体内测试显示支架置入后所有实验兔耐受性良好,食管直径在置入前为(9.2±0.8) mm,置入后1、2、4周分别为(9.7±0.7) mm、(9.6±0.8) mm、(9.6±0.5) mm(P>0.05)。支架组6只兔发生支架移位(1周时1只,2周时1只,4周时4只)。支架组食管上皮、平滑肌层变薄等食管壁重建与对照组比较,差异有统计学意义(P<0.05);支架置入后食管壁损伤及胶原沉积等组织反应与对照组比较,差异无统计学意义(P>0.05)。结论 硅膜-镁合金可降解支架置入兔食管技术上可行,可提供至少2周支撑力,支架移位率可接受,未发生严重食管壁损伤及胶原沉积。

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备注/Memo

备注/Memo:
(收稿日期:2016-12-12)
(本文编辑:边 佶)
更新日期/Last Update: 2017-09-12