[1]刘 晟,沈 强,许 赟,等.微波消融治疗结直肠癌根治术后肝转移患者的疗效分析[J].介入放射学杂志,2016,(08):689-694.
　LIU Sheng,SHEN Qiang,XU Yun,et al.Microwave ablation for the treatment of colorectal liver metastases after radical surgery: analysis of its curative effect [J].journal interventional radiology,2016,(08):689-694.
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微波消融治疗结直肠癌根治术后肝转移患者的疗效分析 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年08期
页码:
689-694
栏目:
非血管介入
出版日期:
2016-08-25

文章信息/Info

Title:
Microwave ablation for the treatment of colorectal liver metastases after radical surgery: analysis of its curative effect 

作者:
刘 晟;  沈 强;  许 赟;  周平盛;  钱国军
Author(s):
LIU Sheng;  SHEN Qiang;  XU Yun;  ZHOU Ping-sheng;  QIAN Guo-jun
Department of Minimal Invasion Therapy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
关键词:
【关键词】 微波消融;  结直肠癌;  肝转移瘤
文献标志码:
A
摘要:
【摘要】 目的 评价微波消融（MWA）在结直肠癌根治术后肝转移治疗中的作用,评估局部疗效及各因素对远期预后的影响。方法 回顾性统计2010年1月至2011年12月接受超声引导下MWA术治疗的106例结直肠癌根治术后肝转移患者的临床资料。观察术后完全消融率、并发症和局部肿瘤进展,计算术后总体生存率和无瘤生存率,并行生存率相关影响因素分析。 结果 106例患者共消融215枚肿瘤,首次消融后209枚达到完全消融（97.2%）；严重并发症发生率2.8%(3/106)。截至随访结束,局部肿瘤进展率6.6% (7/106)；术后中位生存时间35个月；1、3、5 年总体生存率和无瘤生存率分别为87.7%、50.0%、33.0%和55.7%、21.7%、5.7%。亚组分析显示,肿瘤最大直径≤3 cm的患者5年生存率为35.1%,>3 cm的患者5年总生存率为27.3%,差异无统计学意义 ( P =0.077),化疗组5年生存率为38.9%,显著高于未化疗组的10.0%( P =0.003),肝内单发转移瘤患者5年生存率为50.9%，显著高于多发转移瘤患者的16.8% ( P =0.000)。 结论 MWA在直径≤6 cm肝转移瘤的治疗中,即使肿瘤直径较大,在完全消融后也能得到与直径较小的肿瘤相似的局部疗效和远期预后；MWA联合化疗能提高结直肠癌肝转移患者的远期预后,效果优于仅接受MWA；是否接受化疗、肝转移瘤数量及原发病灶手术切除时的Dukes分期是生存率的独立危险因素。

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备注/Memo

备注/Memo:
（收稿日期：2016-05-12）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2016-08-23