[1]陈昆山,张 靖,申 刚,等.经导管动脉化疗栓塞在中晚期肝胚细胞瘤术前的临床应用[J].介入放射学杂志,2016,(03):220-224.
 CHEN Kun- shan,ZHANG Jing,SHEN Gang,et al.Clinical application of preoperative transcatheter arterial chemoembolization in treating advanced hepatoblastomas[J].journal interventional radiology,2016,(03):220-224.
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经导管动脉化疗栓塞在中晚期肝胚细胞瘤术前的临床应用 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年03期
页码:
220-224
栏目:
肿瘤介入
出版日期:
2016-03-25

文章信息/Info

Title:
Clinical application of preoperative transcatheter arterial chemoembolization in treating advanced hepatoblastomas
作者:
陈昆山 张 靖 申 刚 周少毅 李海波 牛传强 谭小云 姜 华
Author(s):
CHEN Kun- shan ZHANG Jing SHEN Gang ZHOU Shao- yi LI Hai- bo NIU Chuan- qiang TAN Xiao- yun JIANG Hua
Department of Interventional Therapy and Vascular Anomalies, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong Province 510623, China
关键词:
【关键词】 经导管动脉化疗栓塞术 肝胚细胞瘤 临床应用 新辅助化疗
文献标志码:
A
摘要:
【摘要】 目的 探讨TACE在中晚期肝胚细胞瘤切除术前治疗的疗效及安全性。方法 回顾性分析确诊的不能一期手术切除的肝胚细胞瘤患儿20例的临床资料,经导管对肿瘤供血动脉行顺铂和吡柔比星碘化油乳化液灌注并作聚乙烯醇泡沫颗粒或微球栓塞,术后4周复查胸腹部CT及AFP。如肿瘤仍无法切除继续TACE,直至肿瘤缩小至适合切除,观察患儿的临床疗效、PRETEXT分期变化、并发症、手术中情况及肿瘤坏死面积,并对远期效果随访。结果 本组患儿共行TACE治疗49次,肿瘤体积缩小达56.2%~91.6%,平均68%(t=8.418,P<0.001),AFP降低达91.4%~99.9%,平均99.2%(t=2.531,P=0.02),PRETEXT分期下降,TACE后未出现严重并发症和不良反应,20例患儿均重新获得手术机会,术中肿瘤易于切除,切除肿瘤标本显示肿瘤坏死面积达63.7%~91.9%,平均82.9%。远期随访,肿瘤切除术后死于肺转移2例、复发1例,17例患儿无瘤存活时间平均21.9个月,随访时间6~48个月。结论 TACE能显著使肝胚细胞瘤瘤体缩小并AFP下降,使中晚期肝胚细胞瘤患儿重新获得手术切除机会,是一种安全、有效的治疗方法。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2015-06-26)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2016-03-22