[1]王 娟,孙美玲,张宏涛,等.外放疗后复发颈部淋巴结转移癌17例125I粒子植入治疗的初步疗效[J].介入放射学杂志,2014,(09):784-787.
 WANG Juan,SUN Mei ling,ZHANG Hong tao,et al.Radioactive 125I seed implantation for the treatment of recurrent cervical lymphatic metastases after radiotherapy: preliminary results in 17 cases[J].journal interventional radiology,2014,(09):784-787.
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外放疗后复发颈部淋巴结转移癌17例125I粒子植入治疗的初步疗效 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年09期
页码:
784-787
栏目:
非血管介入
出版日期:
2014-09-25

文章信息/Info

Title:
Radioactive 125I seed implantation for the treatment of recurrent cervical lymphatic metastases after radiotherapy: preliminary results in 17 cases
作者:
王 娟 孙美玲 张宏涛 唐富龙 隋爱霞 夏海水
Author(s):
WANG Juan SUN Mei ling ZHANG Hong tao TANG Fu long SUI Ai xia XIA Hai shui.
Department of Oncology, Hebei Provincial People’s Hospital, Shijiazhuang, Hebei Province 050051, China
关键词:
【关键词】 颈部淋巴结 转移癌 肿瘤复发 125I粒子植入 近距离放射治疗
文献标志码:
A
摘要:
【摘要】 目的 初步探讨125I粒子植入治疗外放后复发的颈部淋巴结转移癌的安全性及疗效。方法对2011年8月—2012年7月收治的17例颈部淋巴结转移癌既往接受外放疗再次复发患者行回顾性研究。17例患者23处病灶,应用近距离治疗计划系统(TPS)制订治疗计划,确定粒子数目、活度及分布,粒子活度0.3 ~ 0.8 mCi,肿瘤处方剂量为60 ~ 120 Gy,CT及B超双引导下植入,术后24 h内CT扫描,剂量验证D90为(81.4 ± 2.1)Gy。术后每2个月复查CT检测肿瘤大小变化并观察并发症。结果 随访6个月,局部控制率为65.2%,其中,小于4 cm的淋巴结控制率(CR + PR)为90%,而大于4 cm的为46%,P = 0.038,差异有统计学意义;颈Ⅰ、Ⅱ、Ⅲ、Ⅴ区淋巴结各控制率(CR + PR)与未控制率(SD + PD)比较, 差异无统计学意义(P > 0.05);孤立而边界清楚的21个淋巴结控制率为71%,融合而边界不清的淋巴结局部控制率为0。急性皮肤放疗反应Ⅱ度8例,Ⅰ度7例,无严重的其他放疗并发症。结论 125Ⅰ粒子植入治疗外放疗后复发的颈部淋巴结转移癌近期疗效好、创伤小、并发症少。小于4 cm且孤立、边界清楚的淋巴结更适合粒子植入治疗。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2013-12-25)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2014-09-18