[1]陈 翔,白元,姜海滨,等.经皮肺动脉瓣置换动物实验研究[J].介入放射学杂志,2012,(03):235-238.
 ,,et al.Percutaneous pulmonary valve replacement: an experimental study in dogs [J].journal interventional radiology,2012,(03):235-238.
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经皮肺动脉瓣置换动物实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年03期
页码:
235-238
栏目:
实验研究
出版日期:
2012-03-28

文章信息/Info

Title:
Percutaneous pulmonary valve replacement: an experimental study in dogs  
作者:
 陈 翔白元姜海滨朱玉峰顾明标叶忠李卫萍秦永文
Author(s):
 CHEN Xiang BAI Yuan JIANG Haibing ZHU Yufeng GU Mingbiao YE Zhong LI Weiping QIN Yongwen.  
  Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
关键词:
 【关键词】 肺动脉瓣置换 经皮 不锈钢支架 动物实验
文献标志码:
A
摘要:
 【摘要】 目的 探讨新型带瓣膜雕刻支架经皮植入置换肺动脉瓣的可行性和疗效。方法   自行设计圆柱状网状支架,用医用316 L不锈钢激光雕刻而成。将新鲜的猪心包经脱细胞处理后置0.6%戊二醛浸泡36 h,生理盐水洗净,裁剪成人工瓣膜,缝合在不锈钢支架上,制成带瓣膜肺动脉支架。手术前将带瓣膜支架压缩至定制的相应大小的球囊导管上。选择健康犬8只,体重(15.5 ± 3.1)kg,穿刺右股静脉,将带瓣膜支架经导管植入至肺动脉瓣处,置换自身肺动脉瓣膜。手术后通过DSA和超声等方法即刻观察实验效果。结果   1只犬死于术中麻醉意外,7只犬经皮瓣膜置换术均获得成功,术后即时影像和超声检查结果表明人工肺动脉瓣膜功能正常。结论   自制新型带瓣膜支架经导管植入置换肺动脉瓣方法可行,效果理想。

参考文献/References:

[1]   Discigil B, Dearani JA, Puga FJ, et al. Late pulmonary valve replacement after repair of tetralogy of Fallot[J]. J Thorac Cardiovasc Surg, 2001, 121: 344  351.
[2]  Bonhoeffer P, Boudjemline Y, Saliba Z, et al. Percutaneous replacement of pulmonary valve in a rightventricle to pulmonaryartery prosthetic conduit with valve dysfunction[J]. Lancet, 2000, 356: 1403  1405.
[3]   宗刚军, 白   元, 吴   弘, 等. 经导管肺动脉瓣膜植入的实验研究[J]. 介入放射学杂志, 2007, 16: 623  626.
[4]   周永新, 邵   杰, 孙   林, 等. 带瓣膜主动脉瓣支架的研制及经导管植入动物实验[J]. 第二军医大学学报, 2009, 30: 120  123.
[5] Khambadkone S, Coats L, Taylor A, et al. Percutaneous pulmonary valve implantation in humans: results in 59 consecutive patients[J]. Circulation, 2005, 112: 1189  1197.
[6]  Lutter G, Ardehali R, Cremer J, et al. Percutaneous valve replacement: current state and future prospects[J]. Ann Thorac Surg, 2004, 78: 2199  2206.

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 (收稿日期:20110115)
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