[1]胡健,张奇,丁风华,等.经导管封堵治疗合并肺动脉高压的老年继发孔房间隔缺损[J].介入放射学杂志,2008,(01):4.
　HU Jian,ZHANG Qi,DING Fenghua,et al.Transcatheter occlusion of secundum atrial septal defect in elderly patients with pulmonary hypertension[J].journal interventional radiology,2008,(01):4.
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经导管封堵治疗合并肺动脉高压的老年继发孔房间隔缺损()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2008年01期
页码:
4
栏目:
心脏介入
出版日期:
2008-01-15

文章信息/Info

Title:
Transcatheter occlusion of secundum atrial septal defect in elderly patients with pulmonary hypertension
作者:
胡健; 张奇; 丁风华; 杨震坤; 张瑞岩; 张建盛; 沈卫峰
２０００２５上海交通大学医学院附属瑞金医院内科   通讯作者：胡健
Author(s):
HU Jian; ZHANG Qi ; DING Feng－hua; YANG Zhen－kun; ZHANG Rui－yan; ZHANG Jian－sheng; SHEN Wei－feng．
Ruijin Hospital，Medical School of Shanghai Jiaotong University，Shanghai２０００２５，China
关键词:
房间隔缺损; 封堵器; 肺动脉高压
分类号:
R５４１.１
文献标志码:
A
摘要:
目的评估经导管封堵治疗合并肺动脉高压的老年继发孔房间隔缺损（房缺）的疗效和安全性。方法２００２年１月－２００６年１２月于我院行房缺封堵术的３４例患者入选本研究，其中１５例老年合并肺动脉高压的继发孔房缺患者作为肺动脉高压组。全部患者均在术前、术后１d、１、３、６和１２个月行经胸心动超声图和１２导联心电图检查。在透视及经胸心动超声图引导下经导管植入Amplatzer封堵器闭合房缺。结果所有患者封堵器植入均获成功，术中和术后均无并发症发生。肺动脉高压组与非肺动脉高压组年龄分别为（６７±５）岁和（２４±９）岁，（P＜０．０１），心功能分级分别为２．８±０．７和１．７±０．７，（P＜０．０１），房缺直径分别为（３０．５±３．２）mm和（１４．２±４．０）mm（P＜０．０１），封堵器直径分别为（３５．３±４．５）mm和（１８．２±４．４）mm（P＜０．０１），肺动脉收缩压分别为（６５．２±１１．２）mmHg 和（２９．５±３．３）mmHg （P＜０．０１）肺动脉平均压分别为（３１．０±４．４）mmHg 和（１７．９±１．１）mmHg （P＜０．０１），封堵后，肺动脉高压组患者的肺动脉收缩压为（３６．６±１１．４）mmHg ，肺动脉平均压为（２１．６±４．３）mmHg ，均有明显下降，两者与术前比较P均＜０．０１，心功能有明显提高（从术前２．８±０．７增加到１．８±０．８，P＜０．０１）。结论经导管封堵治疗合并肺动脉高压的老年继发孔房缺安全、有效

参考文献/References:

［１］秦永文，丁继军，胡健强，等．经导管闭合房间隔缺损的疗效观察［J］．介入放射学杂志，２００１，１０：７８－８０．
［２］冯碧霞，黄新胜，张镜芳，等．５０岁以上房间隔缺损介入与外科治疗的对比研究［J］．中华胸心血管外科杂志，２００４，２０：１３９－１４１．
［３］邓东安，邓亚安，侯传举，等．超声心动图引导下介入治疗房间隔缺损合并严重肺动脉高压［J］．中国介入影像与治疗学，２００４，１：２３－２５．
［４］潘欣，关韶峰，崔克俭，等．５０岁以上继发孔型房间隔缺损Amplatzer封堵器介入治疗的临床分析［J］．介入放射学杂志，２００５，１４：４８０－４８３．
［５］Swan L，Varma C，Yip J，et al．Transcatheter device closure of atrial septal defects in the elderly：technical considerations and short－term outcomes［J］．Int J Cardiol，２００５，１０７：２０７－２１０．
［６］Cherian G，Uthaman C，Durairaj M，et al．Pulmonary hypertens－ion in isolated secundum atrial septal defect：high frequency in young patients［J］．Am Heart J，１９８３，１０５：９５２－９５７．
［７］Schubert S，Peters B，Abdul－Khaliq H，et al．Left ventricular conditioning in the elderly patient to prevent congestive heart failure after transcatheter closure of atrial septal defect［J］．Catheter Cardiovasc Interv，２００５，６４：３３３－３３７．

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备注/Memo

备注/Memo:
收稿日期：２００７－０７－３１
更新日期/Last Update: 2008-01-15