[1]张 克,杨 涛,郝 斌.下肢动脉硬化闭塞症患者支架植入术后血清miR- 140- 5p与1年内支架内再狭窄相关性研究[J].介入放射学杂志,2022,31(06):555-559.
 ZHANG Ke,YANG Tao,HAO Bin..Correlation between serum microRNA-140-5p level and in-stent restenosis occurring within one year after interventional treatment in patients with lower extremity atherosclerotic occlusive disease[J].journal interventional radiology,2022,31(06):555-559.
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下肢动脉硬化闭塞症患者支架植入术后血清miR- 140- 5p与1年内支架内再狭窄相关性研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
31
期数:
2022年06
页码:
555-559
栏目:
血管介入
出版日期:
2022-07-31

文章信息/Info

Title:
Correlation between serum microRNA-140-5p level and in-stent restenosis occurring within one year after interventional treatment in patients with lower extremity atherosclerotic occlusive disease
作者:
张 克 杨 涛 郝 斌
Author(s):
 ZHANG Ke YANG Tao HAO Bin.
Department of Vascular Surgery, Shanxi Bethune Hospital(Shanxi Academy of Medical Sciences), Taiyuan,Shanxi Province 030032, China
关键词:
【关键词】 微小核糖核酸-140-5p下肢动脉硬化闭塞症支架内再狭窄
文献标志码:
A
摘要:
【摘要】 目的 探讨下肢动脉硬化闭塞症(LEAOD)患者支架植入术后血清微小核糖核酸(miR)-140-5p表达水平与1年内支架内再狭窄(ISR)的关系。方法 选取2019年2月至2020年3月在山西白求恩医院接受支架植入术治疗的136例LEAOD患者作为研究对象。根据术后是否发生ISR分为ISR组(n=52)和非ISR组(n=84)。采用实时荧光定量聚合酶链反应(PCR)检测患者血清miR-140-5p表达,受试者工作特征曲线(ROC)评价miR-140-5p预判支架植入术后1年内ISR的价值,logistic回归分析miR-140-5p与支架植入术后1年内ISR的关系。结果 ISR组泛大西洋学会联盟(TASC)Ⅱ分型B+C型、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)比例均高于非ISR组(均P<0.05)。ISR组手术前后miR-140-5p相对表达水平均低于非ISR组(均P<0.05)。两组术后miR-140-5p相对表达水平均高于术前(均P<0.05),ISR组miR-140-5p相对表达升高程度低于非ISR组(P<0.05)。术后miR-140-5p预判支架植入术后1年内ISR的ROC曲线下面积(AUC)高于术前miR-140-5p、miR-140-5p差值(均P<0.05)。logistic回归分析结果显示,TASCⅡ分型、LDL-C、CRP均为LEAOD患者支架植入术后1年内ISR的独立危险因素(均P<0.05),术后miR-140-5p是术后1年内ISR的独立保护因素(P<0.05)。 结论 LEAOD患者支架植入术后miR-140-5p与术后1年内ISR相关,检测其表达可辅助临床做出更好决策。

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备注/Memo

备注/Memo:
(收稿日期:2021- 08- 25)
(本文编辑:边 佶)
更新日期/Last Update: 2022-07-27