[1]于 奇,吴 杰,高 飞,等.载药微球加载贝伐珠单抗治疗难治性实体瘤4例[J].介入放射学杂志,2019,28(01):81-84.
 YU Qi,WU Jie,GAO Fei,et al.HepaSphere loaded with bevacizumab for the treatment of refractory solid tumors: preliminary results in 4 patients[J].journal interventional radiology,2019,28(01):81-84.
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载药微球加载贝伐珠单抗治疗难治性实体瘤4例()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
28
期数:
2019年01期
页码:
81-84
栏目:
临床研究
出版日期:
2019-01-25

文章信息/Info

Title:
HepaSphere loaded with bevacizumab for the treatment of refractory solid tumors: preliminary results in 4 patients
作者:
于 奇 吴 杰 高 飞 刘 静 张 亮 宋 磊
Author(s):
YU Qi WU Jie GAO Fei LIU Jing ZHANG Liang SONG Lei.
Department of Interventional Radiology, Affiliated Second Hospital, Dalian Medical University, Dalian, Liaoing Province 116027, China
关键词:
【关键词】 难治性实体瘤 贝伐珠单抗 载药微球 TACE HepaSphere微球
文献标志码:
A
摘要:
【摘要】 目的 探讨载药微球(HepaSphere)加载贝伐珠单抗治疗难治性实体瘤的安全性及有效性。方法 2016年8月—2017年3月,4例难治性实体瘤患者接受载药微球加载贝伐珠单抗动脉灌注化疗栓塞术。其中2例为胰腺癌腹腔转移,1例为胃癌术后复发,1例为直肠癌术后肝转移。术后根据mRECIST标准评价疗效,同时评价患者无进展生存时间(PFS),评价治疗的安全性以及不良反应。结果4例患者均可以评价疗效以及不良反应,其中1例为PR,3例为SD。其中胃肠道反应3例,腹痛不适1例,骨髓抑制1例,均为Ⅰ~Ⅱ度,经对症治疗后均好转,无严重不良反应发生。结论 载药微球加载贝伐珠单抗,在治疗难治性实体瘤中疗效肯定,方法安全。

参考文献/References:

[1] Sergio A, Cristofori C, Cardin R, et al. Transcatheter arterial chemoembolization(TACE) in hepatocellular carcinoma(HCC): the role of angiogenesis and invasiveness[J]. Am J Gastroenterol, 2008, 103: 914- 921.
[2] Lencioni R, Llovet JM. Modified RECIST(mRECIST) assessment for hepatocellular carcinoma[J]. Semin Liver Dis, 2010, 30: 52- 60.
[3] Namur J, Citron SJ, Sellers MT, et al. Embolization of hepatocellular carcinoma with drug- eluting beads: doxorubicin tissue concentration and distribution in patient liver explants [J]. J Hepatol, 2011, 55: 1332- 1338.
[4] Terai Y, Kanemura M, Sasaki H, et al. Long- term follow- up of neoadjuvant intraarterial chemotherapy using an original four- lumen double- balloon(4L- DB) catheter for locally advanced uterine cervical cancer[J]. Int J Clin Oncol, 2009, 14: 56- 62.
[5] Shimamoto H, Takizawa K, Ogawa Y, et al. Clinical efficacy and value of redistributed subclavian arterial infusion chemotherapy for locally advanced breast cancer[J]. Jpn J Radiol, 2011, 29:236- 243.
[6] 李国平, 龚高全, 王建华,等. 不可切除的胰腺癌TAI/TACE治疗后回顾性生存分析[J]. 介入放射学杂志, 2015, 24: 118- 123.
[7] 徐国辉, 徐宗全, 周 峥, 等. TACE 联合贝伐珠单抗治疗不可切除结直肠癌肝转移的临床研究[J]. 实用癌症杂志, 2015, 30: 1493- 1497.
[8] Gupta S, Wright KC, Ensor J, et al. Hepatic arterial embolization with doxorubicin- loaded superabsorbent polymer microspheres in an animal model[J]. Cardiovasc Intervent Radiol, 2011, 34: 1021- 1030.
[9] 周振兴, 宋军民, 陈姬华, 等. 贝伐珠单抗在肿瘤治疗中的应用研究进展[J]. 药学进展, 2015, 39: 525- 532.
[10] Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy[J]. N Engl J Med, 2008, 358: 1129- 1136.
[11] Raez LE, Santos ES, Webb RT, et al. A multicenter phase Ⅲ study of docetaxel, oxaliplatin, and bevacizumab in first- line therapy for unresectable locally advanced or metastatic non- squamous cell histology non- small- cell lung cancer(NSCLC)[J]. Cancer Chemother Pharmacol, 2013, 72: 1103- 1110.
[12] Burger RA, Brady MF, Rhee J, et al. Independent radiologic review of the gynecologic oncology group study 0218, a phase Ⅲ trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer[J]. Gynecol Oncol, 2013, 131: 21- 26.
[13] Schefter T, Winter K, Kwon JS, et al. RTOG 0417: Efficacy of bevacizumab in combination with definitive radiation therapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma[J]. Int J Radiat Oncol Biol Phys, 2014, 88: 101- 105.
[14] Sohal DP, Metz JM, Sun W, et al. Toxicity study of gemcitabine,oxaliplatin, and bevacizumab, followed by 5- fluorouracil, oxaliplatin, bevacizumab, and radiotherapy, in patients with locally advanced pancreatic cancer[J]. Cancer Chemother Pharmacol, 2013, 71: 1485- 1491.
[15] Uronis HE, Bendell JC, Altomare I, et al. A phase Ⅱ study of capecitabine, oxaliplatin,and bevacizumab in the treatment of metastatic esophagogastric adenocarcinomas[J]. Oncologist, 2013, 18: 271- 272.
[16] Namur J, Pascale FT, Dinca H, et al. Safety and efficacy compared for two doxorubicin loaded microspheres in liver VX2 model[J]. J Vasc Interv Radiol, 2014, 25: S115- S116.
[17] Prager GW, Lackner EM, Krauth MT, et al. Targeting of VEGF- dependent transendothelial migration of cancer cells by bevacizumab[J]. Mol Oncol, 2010, 4: 150- 160.
[18] van Malenstein H, Maleux G, Vandecaveye V, et al. A randomized phase Ⅱ study of drugeluting beads versus transarterial chemoembo- lization for unresectable hepatocellular carcinoma[J]. Onkologie,2011, 34: 368- 376.

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备注/Memo

备注/Memo:
(收稿日期:2018-01-24)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2019-01-21