[1]朱天宇,朱政斌,丁风华,等.国产左心室隔离装置治疗左心室壁瘤动物实验研究[J].介入放射学杂志,2016,(09):803-809.
　ZHU Tian- yu,ZHU Zheng- bin,DING Feng- hua,et al.Domestic left ventricular partitioning device for the treatment of left ventricular aneurysm： an experimental study in animals[J].journal interventional radiology,2016,(09):803-809.
点击复制

国产左心室隔离装置治疗左心室壁瘤动物实验研究 ()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年09期
页码:
803-809
栏目:
实验研究
出版日期:
2016-09-25

文章信息/Info

Title:
Domestic left ventricular partitioning device for the treatment of left ventricular aneurysm： an experimental study in animals
作者:
朱天宇;  朱政斌;  丁风华;  梅奇峰;  杜 润;  朱劲舟;  张瑞岩
Author(s):
ZHU Tian- yu;  ZHU Zheng- bin;  DING Feng- hua;  MEI Qi- feng;  DU Run;  ZHU Jin- Zhou;  ZHANG Rui- yan
Department of Cardiology， Affiliated Ruijin Hospital， School of Medicine， Shanghai Jiaotong University， Shanghai 200025， China
关键词:
【关键词】 经皮心室重建术;  左心室隔离装置;  心力衰竭;  左心室壁瘤
文献标志码:
A
摘要:
【摘要】 目的 通过动物实验验证经导管植入国产左心室隔离装置（LVPD）Heartech治疗左心室壁瘤的效果。方法 构建4头山羊左心室壁瘤模型，建模12周后植入Heartech LVPD，术后16周处死山羊并取出LVPD，扫描电镜观察其表面内皮细胞生长情况。建模前、建模后、LVPD植入前、植入后及植入16周复查时，左心室造影检测左心室收缩末容积（LVESV）、左心室舒张末容积（LVEDV）、左心室射血分数（LVEF）、每搏射血量（SV）、心输出量（CO）、机械效率（ME）等指标。结果 Heartech LVPD植入16周后检测数据与植入前相比，LVESV分别为（25.02±1.81） ml和（40.71±4.93） ml（P＜0.01），LVEDV分别为（51.53±3.33） ml和（61.51±4.67） ml（P＜0.01），LVEF分别为（50.13±2.99）% 和（33.90±4.29）%（P＜0.01），SV分别为（26.39±2.01） ml和（20.79±2.17） ml（P＜0.01），CO分别为（3.54±0.38） L/min和（3.21±0.36） L/min（P＜0.05），ME分别为（67.56±1.78）%和（48.88±5.07）%（P＜0.01）；LVPD表面内皮细胞生长情况良好。结论经导管植入国产Heartech LVPD治疗左心室壁瘤效果显著。

参考文献/References:

［1］ Costa MA, Pencina M, Nikolic S, et al. The PARACHUTE Ⅳ trial design and rationale: percutaneous ventricular restoration using the parachute device in patients with ischemic heart failure and dilated left ventricles［J］. Am Heart J, 2013, 165: 531- 536.
［2］ 顾东风， 黄广勇， 何 江， 等． 中国心力衰竭流行病学调查及其患病率［J］． 中华心血管杂志， 2003， 31： 3- 6．
［3］ Li J, Li X, Wang Q, et al. ST- segment elevation myocardial infarction in China from 2001 to 2011（the China PEACE- Retrospective Acute Myocardial Infarction Study）: a retrospective analysis of hospital data［J］. Lancet, 2015, 385: 441- 451.
［4］ Bolognese L, Neskovic AN, Parodi G, et al. Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long- term prognostic implications［J］. Circulation, 2002, 106: 2351- 2357.
［5］ Oliveira G, Al- Kindi SG, Bezerra HG, et al. Left ventricular restoration devices［J］. J Cardiovasc Transl Res, 2014, 7: 282- 291.
［6］ Chen J, Normand SL, Wang Y, et al. National and regional trends in heart failure hospitalization and mortality rates for medicare beneficiaries［J］. JAMA, 2011, 306: 1669- 1678.
［7］ Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction: experimental observations and clinical implications［J］. Circulation, 1990, 81: 1161- 1172.
［8］ Moriarty TF. The law of Laplace. Its limitations as a relation for diastolic pressure, volume, or wall stress of the left ventricle［J］.Circ Res, 1980, 46: 321- 331.
［9］ Artrip JH, Oz MC, Burkhoff D. Left ventricular volume reduction surgery for heart failure: a physiologic perspective［J］. J Thorac Cardiovasc Surg, 2001, 122: 775- 782.
［10］ Di Donato M, Sabatier M, Toso A, et al. Regional myocardial performance of non- ischaemic zones remote from anterior wall left ventricular aneurysm［J］. Eur Heart J, 1995, 16: 1285- 1292.
［11］ Schmidt T, Frerker C, Thielsen T, et al. New evidence for favourable effects on haemodynamics and ventricular performance after Parachute?誖implantation in humans［J］. Eur J Heart Fail, 2014, 16: 1112- 1119.
［12］ Nikolic SD, Khairkhahan A, Ryu M, et al. Percutaneous implan- tation of an intraventricular device for the treatment of heart failure: experimental results and proof of concept［J］. J Card Fail, 2009, 15: 790- 797.
［13］ Otasevic P, Sagic D, Antonic Z, et al. First- in- man implantation of left ventricular partitioning device in a patient with chronic heart failure: twelve- month follow- up［J］. J Card Fail, 2007, 13: 517- 520.
［14］ Costa MA, Mazzaferri EL Jr, Sievert H, et al. Percutaneous ventricular restoration using the parachute device in patients with ischemic heart failure: three- year outcomes of the PARACHUTE first- in- human study［J］. Circ Heart Fail, 2014, 7: 752- 758.
［15］ 马 为， 洪 涛， 李建平， 等． 经皮心室重建术——附两例病例报告［J］． 中国介入心脏病学杂志， 2013， 21： 274- 277．
［16］ 丁风华， 方跃华， 杨文洁， 等． 经皮左心室重建术治疗前壁心肌梗死后室壁瘤合并心功能不全一例［J］． 介入放射学杂志， 2014， 23： 886- 888．
［17］ Konstam MA, Kramer DG, Patel AR, et al. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment［J］. J Am Coll Cardiol Cardiovasc Imaging, 2011, 4: 98- 108.
［18］ Ladich E, Otsuka F, Virmani R. A pathologic study of explanted parachute devices from seven heart failure patients following percutaneous ventricular restoration［J］. Catheter Cardiovasc Interv, 2014, 83: 619- 630.
［19］ Bozdag- Turan I, Bemlaoui B, Paranskaya L, et al. Challenges in patient selection for the parachute device implantation［J］. Catheter Cardiovasc Interv, 2013, 82: E718- E725.

相似文献/References:

[1]汤学超,秦永文.经皮心室重建术——心力衰竭治疗新手段[J].介入放射学杂志,2016,(05):453.
　TANG Xue- chao,QIN Yong- wen.Percutaneous ventricular restoration： a novel treatment for heart failure[J].journal interventional radiology,2016,(09):453.
[2]夏炜聪,朱政斌,丁风华,等.国产经皮左心室隔离装置治疗心肌梗死后充血性心力衰竭1例[J].介入放射学杂志,2017,(11):1019.
　XIA Weicong,ZHU Zhengbin,DING Fenghua,et al.Successful treatment of congestive heart failure due to myocardial infarction with homemade left ventricular partitioning device： report of one case[J].journal interventional radiology,2017,(09):1019.

备注/Memo

备注/Memo:
（收稿日期：２０１6-０1-18）
（本文编辑：边 佶）
更新日期/Last Update: 2016-09-19