[1]冯国栋,何仕诚,杜瑞杰,等.射频消融联合骨水泥对兔VX2椎旁肿瘤的杀伤作用[J].介入放射学杂志,2016,(06):519-523.
　FENG Guo-dong,HE Shi-cheng,DU Rui-jie,et al.The killing effect of radiofrequency ablation combined with polymethylmethacrylate injection on paravertebral VX2 carcinoma in experimental rabbits [J].journal interventional radiology,2016,(06):519-523.
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射频消融联合骨水泥对兔VX2椎旁肿瘤的杀伤作用 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年06期
页码:
519-523
栏目:
实验研究
出版日期:
2016-06-25

文章信息/Info

Title:
The killing effect of radiofrequency ablation combined with polymethylmethacrylate injection on paravertebral VX2 carcinoma in experimental rabbits

作者:
冯国栋; 何仕诚; 杜瑞杰; 虞文辉; 朱海东; 方文; 郭金和; 邓钢
Author(s):
FENG Guo-dong;  HE Shi-cheng;  DU Rui-jie;  YU Wen-hui;  ZHU Hai-dong;  FANG Wen;  GUO Jin-he;  DENG Gang
Department of Radiology, Affiliated Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province 210009, China
关键词:
【关键词】聚甲基丙烯酸甲酯;  射频消融;  兔;  VX2肿瘤;  凋亡
文献标志码:
A
摘要:
【摘要】目的探讨射频消融（RFA）联合聚甲基丙烯酸甲酯骨水泥对兔VX2腰椎旁肿瘤的杀伤作用。 方法CT导引下经皮穿刺成功构建兔VX2腰椎旁移植瘤模型48只,随机分为4组,每组12只。A组兔模型瘤灶中心先行RFA,后注入骨水泥0.5 ml；B组单纯注入骨水泥 0.5 ml；C组单纯RFA；D组注入生理盐水0.5 ml,作为对照组。术后24 h处死全部4组模型兔,分别在瘤灶中心或距骨水泥边缘5、10、15、20 mm处不同方向各取2 mm大小组织块4块,检测肿瘤细胞凋亡指数。 结果A、B、C组手术成功率均为91.7%(11/12),D组为100%(12/12)。A、C组瘤灶中心半径10 mm范围内肿瘤细胞呈大片状凝固性坏死,细胞形态消失,几乎检测不出凋亡存在。A组距骨水泥边缘10、15、20 mm处平均肿瘤细胞凋亡率分别为(69.48±1.27)%、(59.05±3.02)%、(21.03±2.20)%,与对照组(10.25±0.79)%相比差异均有统计学意义(P＜0.01)；B组距骨水泥边缘5、10、15 mm处平均肿瘤细胞凋亡率分别为(62.52±2.07)%、(45.07±3.14)%、(17.41±1.12)%,与对照组相比差异均有统计学意义(P＜0.01),而20 mm处平均肿瘤细胞凋亡率为(11.15±0.97)%,与对照组相比差异无统计学意义(P＞0.01)；C组距瘤灶中心10、15、20 mm处平均肿瘤细胞凋亡率分别为(67.74±3.33)%、(56.36±3.63)%、(20.71±1.11)%,与B组、D组相比差异有统计学意义(P＜0.01),与A组相比差异无统计学意义(P＞0.01)。 结论RFA和骨水泥均可促进肿瘤细胞凋亡,RFA杀伤肿瘤范围更大,RFA联合骨水泥对肿瘤杀伤作用无明显增强。

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备注/Memo

备注/Memo:
(收稿日期：2015-12-27)


(本文编辑：边佶)
更新日期/Last Update: 2016-06-21