[1]陆 健,刘 琳,陈志瑾,等.进展期非小细胞肺癌125I粒子植入前后CEA、 CYFRA21- 1变化与临床疗效评估[J].介入放射学杂志,2016,(03):234-238.
　LU Jian,LIU Lin,CHEN Zhi- jin,et al.The changes of CEA and CYFRA21- 1 levels after 125I seed implantation in advanced non- small cell lung cancer and their correlation with clinical effectiveness[J].journal interventional radiology,2016,(03):234-238.
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进展期非小细胞肺癌125I粒子植入前后CEA、 CYFRA21- 1变化与临床疗效评估 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年03期
页码:
234-238
栏目:
非血管介入
出版日期:
2016-03-25

文章信息/Info

Title:
The changes of CEA and CYFRA21- 1 levels after 125I seed implantation in advanced non- small cell lung cancer and their correlation with clinical effectiveness
作者:
陆 健;  刘 琳;  陈志瑾;  王忠敏;  程英升;  贡 桔;  夏 宁
Author(s):
LU Jian;  LIU Lin;  CHEN Zhi- jin;  WANG Zhong- min;  CHENG Ying- sheng;  GONG Ju;  XIA Ning
Medical College of Soochow University， Suzhou， Jiangsu Province 215123， China
关键词:
【关键词】 非小细胞肺癌;  CT引导;  125I粒子;  肿瘤标志物
文献标志码:
A
摘要:
【摘要】 目的 观察CT引导下125I 放射性粒子组织间植入治疗进展期非小细胞肺癌（NSCLC）的临床疗效及125I粒子植入前后血清癌胚抗原（CEA）和细胞角质素片段抗原（CYFRA21- 1）的动态水平。方法 对28例不能手术切除的进展期NSCLC患者施行CT引导下植入125I 放射性粒子，并用放射免疫方法测定125I 放射性粒子植入治疗前后的患者血清CEA和CYFRA21- 1水平。结果 治疗后随访1～37个月，全组中位生存时间为17个月，1、2和3年生存率分别为72.0%、30.8%、6.2%。中位局部控制时间为15.5个月，1年、2年的年局部控制率分别为58.0%、20.3%。125I 粒子植入后1、3个月，患者血清中CEA和CYFRA21- 1水平与植入前比较有明显下降（P<0.05）。治疗后CEA降低组死亡率53.9%，升高组死亡率86.7%（P=0.055）；治疗后CYFRA21- 1降低组死亡率36.4%，升高组死亡率94.1%（P=0.001）。结论 CT引导下植入125I 放射性粒子治疗进展期NSCLC，临床近期疗效确切，是一种安全、有效、并发症少的介入治疗方法；且能有效降低CEA和CYFRA21- 1水平，肿瘤标志物水平的监测有助于预测患者的预后。

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备注/Memo

备注/Memo:

（收稿日期：２０１5-1０-19）
（本文编辑：俞瑞纲）

更新日期/Last Update: 2016-03-22