[1]张 雯,李 说,颜志平,等.植入性门静脉主干癌栓兔模型建立及评估[J].介入放射学杂志,2015,(09):801-806.
　ZHANG Wen,LI Shuo,YAN Zhi- ping,et al.Implanted main portal venous tumor thrombus model in experimental rabbits： its establishment and evaluation[J].journal interventional radiology,2015,(09):801-806.
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年09期
页码:
801-806
栏目:
实验研究
出版日期:
2015-09-25

文章信息/Info

Title:
Implanted main portal venous tumor thrombus model in experimental rabbits： its establishment and evaluation
作者:
张 雯;  李 说;  颜志平;  罗剑钧;  刘清欣;  瞿旭东;  王建华
Author(s):
ZHANG Wen;  LI Shuo;  YAN Zhi- ping;  LUO Jian- jun;  LIU Qing- xin;  QU Xu- dong;  WANG Jian- hua
Department of Interventional Radiology， Zhongshan Hospital， Fudan University， Shanghai 200032， China
关键词:
【关键词】 VX2细胞株;  动物模型;  肝细胞癌;  门静脉癌栓;  多排螺旋CT
文献标志码:
A
摘要:
【摘要】 目的 探讨建立稳定的门静脉主干癌栓（MPVTT）动物模型并作客观评估，为进一步临床治疗研究提供基础。方法 24只新西兰大白兔随机分成对照组（A组，n=10）和实验组（B组，n=14）。实验组在门静脉主干前壁缝一荷包，将瘤条经荷包中央注入门静脉腔内，并通过预留缝线悬挂固定在门静脉主干内壁；对照组开腹后仅在门静脉主干前壁作荷包缝合。术后观察动物一般情况、体重及生存时间。术后每周行多排螺旋CT检查，观察门静脉癌栓（PVTT）生长及转移。分阶段处死两组部分实验兔作病理检查，观察PVTT体积和转移情况。剩余兔观察生存时间。结果 实验组门静脉主干成瘤率达100%。实验组（B9～14号兔）及对照组术后第35天平均体重分别为（1.48±0.19） kg和（2.08±0.17） kg，实验组（B9～14号兔）平均生存时间为（41.7±4.72） d。多排螺旋CT显示PVTT及门静脉阻塞后侧支循环和转移灶，病理学检查证实门静脉管腔内癌栓存在及转移灶。结论 成功建立了稳定的可供影像学客观评价的MPVTT动物模型，并证实增强多排螺旋CT对诊断和监测PVTT生长和转移有良好价值，为临床治疗MPVTT研究建立基础。

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备注/Memo

备注/Memo:
（收稿日期：２０１4-12-26）
（本文编辑：边 佶）
更新日期/Last Update: 2015-09-23