[1]石华铮,刘士远,朱海云,等.PET/CT及DWI MRI早期评估兔VX2肉瘤射频消融效果[J].介入放射学杂志,2015,(03):243-247.
 SHI Hua zheng,LIU Shi yuan,ZHU Hai yun,et al.FDG PET/CT and diffusion weighted MRI evaluation of the early therapeutic effect of radiofrequency ablation for VX2 sarcomas in rabbits[J].journal interventional radiology,2015,(03):243-247.
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PET/CT及DWI MRI早期评估兔VX2肉瘤射频消融效果 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年03期
页码:
243-247
栏目:
实验研究
出版日期:
2015-03-25

文章信息/Info

Title:
FDG PET/CT and diffusion weighted MRI evaluation of the early therapeutic effect of radiofrequency ablation for VX2 sarcomas in rabbits
作者:
石华铮 刘士远 朱海云 杨春山 高 欣 平照福 寿 毅华 威 吴 翔
Author(s):
SHI Hua zheng LIU Shi yuan ZHU Hai yun YANG Chun shan GAO Xin PING Zhao fu SHOU Yi HUA Wei WU Xiang.
Department of Radiology, Shanghai Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China
关键词:
【关键词】 射频消融 弥散加权像 兔VX2肿瘤 PET/CT 早期疗效
文献标志码:
A
摘要:
【摘要】 目的 探讨弥散加权(DWI) MRI和18F FDG PET/CT评估兔VX2肉瘤射频消融(RFA)治疗早期效果的价值。方法 14只新西兰白兔双侧后肢接种VX2肉瘤建模,一侧后肢VX2肉瘤接受超声引导下RFA治疗(RFA组),对侧后肢不进行射频治疗(对照组)。RFA治疗后2 d行DWI MRI检查,治疗后3 d行PET/CT检查。分别计算肿瘤病灶和消融灶表观弥散系数(ADC)值和标准摄取值(SUV)值。根据外科切除病灶组织病理学检查结果金标准,分别对DWI MRI、PET/CT及两者联合等3种方法评估RFA瘤灶行临床诊断一致性Kappa检验。结果 VX2肉瘤RFA前,DWI MRI显示T1低信号,T2高信号,T1加权像环状强化,PET/CT显示18F FDG呈结节状或环状聚集;消融后DWI MRI显示T1高信号,T2轻度高密度,T1加权像轻度强化,PET/CT显示18F FDG浓聚程度减低。消融瘤灶ADC值为(1.52 ± 0.24) × 10-3 mm2/s,明显高于未消融瘤灶(1.09 ± 0.12) × 10-3 mm2/s(P < 0.05);SUV值为(0.60 ± 0.30),明显低于未消融瘤灶(9.60 ± 3.20)(P < 0.05)。单独DWI MRI与单独PET/CT评估结果的敏感性、特异性及准确性与组织病理学诊断结果的一致性Kappa值分别为0.357和0.428,无显著性差别(P > 0.05),DWI MRI联合PET/CT评估结果与组织病理学诊断结果的一致性Kappa值为0.786,与前两者均有显著性差别(P < 0.05)。结论 DWI MRI显像ADC值和FDG PET/CT显像SUV值是评估RFA治疗早期效果的有临床应用价值的指标。DWI MRI与FDG PET/CT诊断肿瘤病灶治疗效果各具优势,两者联合应用可有效提高疗效评估的准确性。

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备注/Memo

备注/Memo:
(收稿日期:2014-12-08)
(本文编辑:边 佶)
更新日期/Last Update: 2015-03-29